| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5854074 | Food and Chemical Toxicology | 2011 | 7 Pages |
Green tea is believed to be beneficial to health because it possesses antioxidant, antiviral and anticancer properties. The potential toxicity of green tea when administered at high doses via concentrated extracts, however, has not been completely investigated. The objective of the present study was to evaluate the safety of green tea extract in ICR mice using a subacute exposure paradigm. In this study, mice were orally administered (gavage) green tea extract at doses of 0 (as normal group), 625, 1250 and 2500 mg/kg body weight/day for 28 days. The results showed that oral administration of green tea extract did not cause adverse effects on body weight, organ weights, hematology, serum biochemistry, urinalysis or histopathology. Additionally, administering green tea extract via gavage significantly reduced triglyceride and cholesterol levels. These observed effects could be attributed to the high levels of catechins present in green tea as these compounds have been reported to have beneficial health effects. The no-observed-adverse-effect level for green tea extract derived from the results of the present study was 2500 mg/kg body weight/day.
⺠Evaluate the safety of green tea extract in ICR mice using a subacute exposure paradigm. ⺠Oral administration of green tea extract did not cause adverse effects. ⺠Administering green tea extract via gavage reduced triglyceride and cholesterol levels. ⺠The no-observed-adverse-effect level for green tea extract derived from the present study was 2500 mg/kg body weight/day.
