Article ID Journal Published Year Pages File Type
5854115 Food and Chemical Toxicology 2011 8 Pages PDF
Abstract
► The inhibitory effects of fucoidan on LPS-induced pro-inflammatory mediators in BV2 microglia were investigated. ► Fucoidan inhibited production of NO and PGE2, and levels of iNOS, COX-2, and pro-inflammatory cytokines. ► Moreover, fucoidan exhibited anti-inflammatory properties by suppression of NF-κB, MAPK, and AKT pathways. ► We conclude that fucoidan could be used for development of nutraceuticals for inflammatory and neurodegenerative disorders.
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