Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5854246 | Food and Chemical Toxicology | 2010 | 5 Pages |
Abstract
The objective of this study was to obtain data on the safety-in-use of yeast hydrolysate in 10-30Â kDa molecular weight as a dietary supplement by assessing its acute and subacute oral toxicity in female and male Sprague-Dawley (SD) rats. The single oral dose of the hydrolysate at 5000Â mg/kg did not produce mortality or significant changes in the general behavior and gross appearance of the internal organs of rats. In subacute toxicity study, the hydrolysate was administered orally at a dose of 1000Â mg/kg/day for a period of 14Â days. The satellite group was treated with the hydrolysate at the same dose and the same period and kept for another 14Â days after treatment. There were no significant differences in organ weights between control and treated group of both sexes. Hematological analysis and blood chemistry revealed no toxicity effects of Saccharomyces cerevisiae hydrolysate. Pathologically, neither gross abnormalities nor histopathological changes were observed. These results show that the hydrolysate possesses very low toxicity as indicated in SD rat model.
Keywords
Yeast hydrolysateMCVMCHCMCHGRASOECDWBCALTHCTRBCH&EASTAspartate aminotransferaseAlanine aminotransferasePeriodic Acid Schiffgenerally recognized as safeMean corpuscular volumeBUNSaccharomyces cerevisiaeAcute toxicitymean corpuscular hemoglobinSubacute toxicityMean corpuscular hemoglobin concentrationPASblood urea nitrogenhematocritHematoxylin and EosinHemoglobinHgbwhite blood cellred blood cell
Related Topics
Life Sciences
Agricultural and Biological Sciences
Food Science
Authors
Eun-Young Jung, Hyun-Sun Lee, Un Jae Chang, Song Hwan Bae, Ki Han Kwon, Hyung Joo Suh,