Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6396070 | Food Research International | 2015 | 8 Pages |
Abstract
Eleven extracts were non-cytotoxic on RAW 264.7. Data obtained suggest the capacity of these Argentine Puna plant extracts to inhibit the production of inflammatory mediators (nitric oxide and prostaglandin) at different levels. The plant extracts can affect enzyme expression and/or enzyme activity, and they can also act by NO scavenging. Each extract exerts its anti-inflammatory effect through different mechanisms. The inhibitory ability on pro-inflammatory enzymes by these hydroalcoholic extracts supports their potential use as sources of natural anti-inflammatory agents. Moreover, all extracts were non-toxic on Artemia salina toxicity test. The consumption of dietary supplements prepared with these plant species could be used to prevent the development of chronic inflammatory pathologies.
Keywords
PBS4-dimethylaminocinnamaldehydeDMACPGSLTSiNOSDTNBGAEDNPHPVDFTNFαCOXLPSDMEM2,4-dinitrophenylhydrazineDMSODulbecco's modified Eagle's mediumMTTcyclooxygenasegallic acid equivalentsLOXELISAtumor necrosis factor alphaDimethylsulfoxideinducible nitric oxide synthaseCyclooxygenase-2Phosphate buffered salineLeukotrieneslipoxygenaselipopolysaccharidequercetin equivalentsNitric oxidenitric oxide synthasedry weightProstaglandinsprostaglandinPolyvinylidene fluoride
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Authors
Romina Torres Carro, MarÃa Inés Isla, José Luis RÃos, Rosa MarÃa Giner, MarÃa Rosa Alberto,