Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7310231 | Appetite | 2014 | 5 Pages |
Abstract
The objective of this research was to determine the dose-response effects of a palatable, viscous and gel forming fibre, PolyGlycopleX® (PGX®), [(α-D-glucurono-α-manno-β-D-manno-β-D-gluco), (α-Lgulurono-β-D mannurono), (β-D-gluco-β-D-mannan)] on satiety, and to gain insight into the underlying mechanisms that lead to appetite inhibition. Healthy subjects (nâ=â10), aged between 20.3 and 29.2 years, consumed PGX®, in granular form at 2.5, 5.0 and 7.5âg, and a 5g inulin control, with a standard breakfast. The PGX® doses of 2.5 and 7.5âg mixed with water at the start of breakfast increased satiety (iAUC of 140.0 and 157.7, Pâ=â0.025 and 0.001, respectively) compared to the control. The most effective dose (7.5g) was palatable and corresponded to a 34% increase in fullness, measured using a visual analogue scale and incremental area under the curve, and resulted in a delayed postprandial glycaemic response when compared with the control.
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Authors
Vicky A. Solah, Jennie C. Brand-Miller, Fiona S. Atkinson, Roland J. Gahler, Veronica Kacinik, Michael R. Lyon, Simon Wood,