STAT3: The art of multi-tasking of metabolic and immune functions in obesity

Article ID	Journal	Published Year	Pages	File Type
8358801	Progress in Lipid Research	2018	51 Pages	PDF

Abstract

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that has recently attracted increased attention. Accumulating studies have demonstrated that STAT3 plays an important role in various diseases, such as cancer and ischemic injury. In light of the distinctive effects of STAT3 on the regulation of metabolism and immune responses, we present the elaborate network of STAT3 in obesity. In this review, we first introduce the general background of STAT3, including a discussion regarding the STAT family and the characterization and regulation of STAT3. Then, we describe the STAT3 signaling network and its pathophysiological roles in lipid and glucose metabolism and immune function. Finally, we highlight the research progress regarding STAT3 in obesity. The information presented here may be useful for the design of future studies and may highlight the potential of STAT3 as a future therapeutic target for obesity.

Keywords

AMPK CREB EGFR NF-κB PI3K LPS OSM SUMO OXPHOS mTOR AOX EPO CNTF HDAC SHP SRC NPY AgRP POMC BAT PTP PPAR IRS pKa CBP CT-1 Kir TGF GM-CSF PEPCK TLR4 PIK3CA SOCS3 VEGFR ISG Tyk2 LSD1 G6Pase SREBP RTK granulocyte-macrophage colony stimulating factor HSL acyl-CoA oxidase SH2 T helper FOX PRDM16 FERM PIAS Neuropoietin LIF protein inhibitors of activated STAT Janus kinase natural killer cyclic AMP AMP-activated protein kinase C/EBP cAMP HCC iGFR MAPK ROS Ucp1 STAT Atgl erythropoietin insulin receptor substrate oncostatin M Immune interferon IFN interferon stimulated gene interleukin brown adipose tissue transforming growth factor tyrosine kinase 2 forkhead box CNS lysine specific demethylase 1 electron transport chain suppressor of cytokine signaling 3 central nervous system body mass index BMI leukemia inhibitory factor ciliary neurotrophic factor nuclear factor-κB phosphoenolpyruvate carboxykinase Oxidative phosphorylation Arc adipose triglyceride lipase hormone-sensitive lipase lipopolysaccharide Lipid Signal transducer and activator of transcription signal transducer and activator of transcription 3 Metabolism Obesity mammalian target of rapamycin arcuate nucleus Src Homology 2 histone deacetylase ETc CCAAT/enhancer-binding protein CREB-binding protein Sterol regulatory element-binding protein Protein tyrosine phosphatase uncoupling protein 1 cAMP response element-binding protein protein kinase A mitogen-activated protein kinase proopiomelanocortin agouti-related peptide JAK WAT cardiotrophin-1 Hepatocellular carcinoma small ubiquitin-like modifier glucose-6-phosphatase Reactive oxygen species steroid receptor coactivator Toll-like receptor 4 Receptor Tyrosine Kinase vascular endothelial growth factor receptor Epidermal growth factor receptor Insulin-like growth factor receptor peroxisome proliferator-activated receptor Neuropeptide Y