Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8358819 | Progress in Lipid Research | 2017 | 53 Pages |
Abstract
Solid lipid nanoparticle (SLN), nanostructured lipid carriers (NLC) and hybrid nanoparticles, have gained increasing interest as drug delivery systems because of their potential to load and release drugs from the Biopharmaceutical classification system (BCS) of class II (low solubility and high permeability) and of class IV (low solubility and low permeability). Lipid properties (e.g. high solubilizing potential, biocompatibility, biotolerability, biodegradability and distinct route of absorption) contribute for the improvement of the bioavailability of these drugs for a set of administration routes. Their interest continues to grow, as translated by the number of patents being field worldwide. This paper discusses the recent advances on the use of SLN, NLC and lipid-polymer hybrid nanoparticles for the loading of lipophilic, poorly water-soluble and poorly permeable drugs, being developed for oral, topical, parenteral and ocular administration, also discussing the industrial applications of these systems. A review of the patents filled between 2014 and 2017, concerning the original inventions of lipid nanocarriers, is also provided.
Keywords
ICGPCLBVCNIRTransferrinmCRPCEISAIndocyanin greenERLMTXEGCGHSPCGRASTMXmPEGSLNNLCHPHDMBATETPTXDSPE-PEG20007,12-dimethylbenzanthracenebiopharmaceutical classification system (BCS)generally recognised as safeCURPLGATPLDTXMDRP85BCS Class IIAceclofenacPDIDOXLPNsAUCUSPIOHCCNPsROSSORErlotinibMRIepigallocatechin gallateBupivacainetamoxifentetrandrineMagnetic resonance imagingNanostructured lipid carriersCNSDoxorubicinACLBCsBBBNSCLCNon-small cell lung cancerMetastatic castration-resistant prostate cancerSorafenibBiopharmaceutical classification systemcentral nervous systempolydispersity indexLidocaineNear infraredBlood-brain barrierMethotrexateMultidrug resistancearea under the curveNanoparticlesSolid lipid nanoparticlesLipid-polymer hybrid nanoparticlesHigh-pressure homogenizationhydrogenated soy phosphatidylcholinehuman immunodeficiency virusHIVPaclitaxelpoly(lactic-co-glycolic acid)Poly(ethylene glycol)PolycaprolactonePEGHepatocellular carcinomaCurcuminReactive oxygen species
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Authors
M.C. Teixeira, C. Carbone, E.B. Souto,