Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8358825 | Progress in Lipid Research | 2017 | 20 Pages |
Abstract
The role of lipids in cell, tissue, and organ physiology is crucial; as many diseases, including cancer, diabetes, neurodegenerative, and infectious diseases, are closely related to absorption and metabolism of lipids. Mass spectrometry (MS) based methods are the most developed powerful tools to study the synthetic pathways and metabolic networks of cellular lipids in biological systems; leading to the birth of an emerging subject lipidomics, which has been extensively reviewed. Nuclear magnetic resonance (NMR), another powerful analytical tool, which allows the visualization of single atoms and molecules, is receiving increasing attention in lipidomics analyses. However, very little work focusing on lipidomic studies using NMR has been critically reviewed. This paper presents a first comprehensive summary of application of 1H, 13C & 31P NMR in lipids and lipidomics analyses. The scientific basis, principles and characteristic diagnostic peaks assigned to specific atoms/molecular structures of lipids are presented. Applications of 2D NMR in mapping and monitoring of the components and their changes in complex lipids systems, as well as alteration of lipid profiling over disease development are also reviewed. The applications of NMR lipidomics in diseases diagnosis and food adulteration are exemplified.
Keywords
chloroform-dHSQCTLCPUFAsTOCSYHDLD2ONOESPECHCl3CDTACDCl3Chromium(III) acetylacetonatePLSLC-NMRSDSDihydrosphingomyelinEPADHSMnuclear magnetic resonanceEDTAEthylenediaminetetraacetic acidnuclear overhauser effectPEESolid phase extractionsphingomyelinEicosapentaenoic aciddocosahexaenoic acidphosphatidic acidPolyunsaturated fatty acidsDeuterium OxideDiseaseAlzheimer's diseasecoronary artery diseaseLipid analysisTAG یا triacylglycerols TriglyceridesNMRFood adulterationDHANuclear magnetic resonance (NMR)sodium dodecyl sulfateCesiumCADFTIRMass spectrometryFourier transform infrared spectroscopyTotal correlation spectroscopyphosphatidylinositolphosphatidylcholinephosphatidylglycerolphosphatidylethanolaminePhosphatidylserinePhospholipidshigh density lipoproteinlow density lipoproteinLDLLipidomicsMetabolitesMethanolMeOHHigh performance chromatographyHPLCthin-layer-chromatographyGas chromatographyChloroform
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Authors
Jingbo Li, Thomas Vosegaard, Zheng Guo,