Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8409120 | Current Opinion in Food Science | 2018 | 6 Pages |
Abstract
Some food proteins exhibit hypocholesteromic activity, which is largely associated with peptide fragments released after their enzymatic hydrolysis. This review provides a highlight of the recent progress on the hypocholesterolemic mechanisms of food protein-derived peptides, which include bile acid binding, inhibition of cholesterol micellar solubility and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (statin-like activity), and targeting of proprotein convertase subtilisin/kexin type 9 interaction with low-density lipoprotein receptor, and sterol regulatory element-binding protein and hepatocyte nuclear factor 1α pathways.
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Authors
Ruth Boachie, Shixiang Yao, Chibuike C Udenigwe,