| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8546275 | Food and Chemical Toxicology | 2018 | 35 Pages |
Abstract
- HT is a potent inhibitor of α-syn fibril formation.
- α-Syn fibrils can be effectively destabilised by HT.
- HT completely counteracts the neurotoxicity induced by α-syn.
- HT is a promising compound for developing strategies to tackle PD.
Keywords
PBSHeme oxigenase-1NQO1αsynEFSAHO-1AβNrf2DMEM3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromideDMSOHPAaDulbecco's modified Eagle's mediumMTTNAD(P)H:quinone oxidoreductaseROSEuropean Food Safety AuthorityTemThTAlzheimer's diseaseParkinson's diseaseTyrTyrosolThioflavin TDimethyl sulfoxideblood brain barrierBBBPhosphate buffered salineTransmission electronic microscopyHydroxytyrosolamyloid-β peptideReactive oxygen species
Related Topics
Life Sciences
Agricultural and Biological Sciences
Food Science
Authors
Ruth Hornedo-Ortega, Ana B. Cerezo, Ana M. Troncoso, M. Carmen Garcia-Parrilla,