Protective effects of (-)-epicatechin and the colonic metabolite 3,4-dihydroxyphenylacetic acid against glucotoxicity-induced insulin signalling blockade and altered glucose uptake and production in renal tubular NRK-52E cells

Article ID	Journal	Published Year	Pages	File Type
8546294	Food and Chemical Toxicology	2018	10 Pages	PDF

Keywords

PEPCK HPPA NRK-52E cells Insulin signalling pathway SGLT-2 DHBA 2-NBDG GLUT AMPK GSK-3 PI3K FBS IRS epicatechin (-)-Epicatechin 2,3-dihydroxybenzoic acid 3,4-dihydroxyphenylacetic acid Akt/PKB insulin receptor substrate Glucose transporter foetal bovine serum Glucotoxicity phosphatidylinositol-3-kinase phosphoenolpyruvate carboxykinase Glucose homeostasis 5′-AMP-activated protein Kinase protein kinase B glycogen synthase kinase-3 glycogen synthase insulin receptor

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Life Sciences Agricultural and Biological Sciences Food Science

Protective effects of (-)-epicatechin and the colonic metabolite 3,4-dihydroxyphenylacetic acid against glucotoxicity-induced insulin signalling blockade and altered glucose uptake and production in renal tubular NRK-52E cells

Authors

David Álvarez-Cilleros, MarÃa Ángeles MartÃn, Sonia Ramos,