Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8546911 | Food and Chemical Toxicology | 2018 | 12 Pages |
Abstract
Campomanesia pubescens is a fruit plant widely distributed in South America and used by the population for medicinal and nutritional purposes, with important economic and cultural value. This study evaluated the toxic potential of the ethanolic extract from C. pubescens (EEFCP) fruits through acute and short-term toxicity tests. For the acute toxicity test, female rats received a single oral dose of 2000â¯mg/kg body weight of EEFCP and were observed for 14 days. In the short-term toxicity test, male and female rats received repeated oral doses of 125, 250, 500 or 1000â¯mg/kg of EEFCP, being treated and observed for 28 days, and after the treatment period, a satellite and satellite control group remained under observation for another 14 days. No mortality, clinical and organ weight alterations were observed, indicating that LD50 is greater than 2000â¯mg/kg body weight. In addition, the doses tested did not produce significant changes in the behavioral, physiological, hematological or histopathological parameters of animals. These results demonstrate the low acute and short-term toxicity of EEFCP in rats. The data obtained are of great relevance since they provide important information about a plant species of great economic, nutritional and ethnopharmacological value.
Keywords
LD50Repeated dosesUDPMCVMCHCMCHOECDALTRDWHDLASTAspartate aminotransferaseAlanine aminotransferaseSafetyMean corpuscular volumeCNSWorld Health OrganizationOrganization for Economic Cooperation and DevelopmentAcute toxicitycentral nervous systemRed cell distribution widthhigh density lipoproteinmean corpuscular hemoglobinPreclinical studiesMean corpuscular hemoglobin concentrationWHO
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Authors
Gustavo Roberto Villas Boas, Ariany Carvalho dos Santos, Roosevelt Isaias Carvalho Souza, Flávio Henrique Souza de Araújo, Giseli Karenina Traesel, Jhony Moreira Marcelino, Ana Paula Stefanello da Silveira, Brunna Charlla Feitosa Farinelli,