Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8547065 | Food and Chemical Toxicology | 2018 | 24 Pages |
Abstract
In the present study, we evaluated the effects of M. pruriens administration on metabolic parameters, oxidative stress and kidney nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathways in high-fructose fed rats. Male rats (nâ¯=â¯28) were divided into 4 groups as control, M. pruriens, fructose, and M. pruriens plus fructose. All rats were fed a standard diet supplemented or no supplemented with M. pruriens (200â¯mg/kg/d by gavage). Fructose was given in drinking water for 8 weeks. High fructose consumption led to an increase in the serum level of glucose, triglyceride, urea and renal malondialdehyde (MDA) levels. Although M. pruriens treatment reduced triglyceride and MDA levels, it did not affect other parameters. M. pruriens supplementation significantly decreased the expression of NF-Ò¡B and decreased expression of Nrf2 and HO-1 proteins in the kidney. This study showed that the adverse effects of high fructose were alleviated by M. pruriens supplementation via modulation of the expression of kidney nuclear transcription factors in rats fed high fructose diet.
Keywords
NF-κBMDAheme-oxygenase 1Nrf2kelch like-ECH-associated protein 1HO-1IKKkeap1IκB kinasetumor necrosis factor-αMetabolic syndromeantioxidant response elementTranscription factorsTNF-αnuclear factor (erythroid-derived 2)-like 2nuclear factor kappa-light-chain-enhancer of activated B cellsmalondialdehydeMucuna pruriensARE
Related Topics
Life Sciences
Agricultural and Biological Sciences
Food Science
Authors
Ramazan Ulu, Nevzat Gozel, Mehmet Tuzcu, Cemal Orhan, Ä°rem Pembegül YiÄit, Ayhan Dogukan, Hafize Telceken, Ãzlem Ãçer, Zeki Kemeç, Dilara Kaman, Vijaya Juturu, Kazim Sahin,