| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8547434 | Food and Chemical Toxicology | 2018 | 40 Pages |
Abstract
- Phosphatidic acid increases in liver and circulation in mice after APAP overdose.
- Phosphatidic acid increases in circulation of humans with APAP hepatotoxicity.
- Reducing phosphatidic acid content in the liver blunts liver regeneration.
- Phosphatidic acid may affect liver regeneration through mTOR signaling.
Keywords
Lyso-PANACmTORALTPCNAAPAPGPATPAPULNALFLC-ESI-MS/MSN-acetylcysteinePHxAlanine aminotransferaseProliferating Cell Nuclear AntigenAcetaminophenphosphatidic acidlysophosphatidic acidUpper limit of normalphosphatidic acid phosphohydrolaseAcute liver failureMechanistic target of rapamycinPartial hepatectomyglycerol-3-phosphate acyltransferase
Related Topics
Life Sciences
Agricultural and Biological Sciences
Food Science
Authors
Andrew J. Lutkewitte, George G. Schweitzer, Stefanie Kennon-McGill, Melissa M. Clemens, Laura P. James, Hartmut Jaeschke, Brian N. Finck, Mitchell R. McGill,