Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8547969 | Food and Chemical Toxicology | 2018 | 7 Pages |
Abstract
Aflatoxin B1 (AFB1) elicits serious threats to public health due to its widespread occurrence, as well as its teratogenic, carcinogenic and mutagenic effects. This study aimed to evaluate the toxicity of AFB1 and assess the ameliorative efficacy of Bacillus subtilis ANSB060 on aflatoxicosis in Yellow River carp. A total of 750 juvenile Yellow River carp were allocated into five dietary treatments for 60 days. Diet C0 represented for the negative control, diet M0 containing about 50â¯Î¼g AFB1/kg diet represented for the positive control, and diet M0.25, M0.5 and M1.0 was diet M0 supplemented with B. subtilis ANSB060 at a dose of 0.25â¯Ãâ¯109, 0.5â¯Ãâ¯109 and 1.0â¯Ãâ¯109â¯CFU/kg diet, respectively. The results showed that supplementation of strain ANSB060 restored the reduced body weight and enhanced feed conversion ratio of carp induced by AFB1 towards normal. ANSB060 could also relieve the alterations in hepatic morphology, improve digestive enzyme activities of hepatopancreas and intestine, as well as decrease AFB1 residues in carp's hepatopancreas and gonad. It is concluded that ANSB060 has a protective effect in carp with aflatoxicosis, with a promising potential in feed industrial applications.
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Authors
Yu Fan, Laiting Liu, Lihong Zhao, Xinping Wang, Dacai Wang, Churan Huang, Jianyun Zhang, Cheng Ji, Qiugang Ma,