Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8549392 | Food and Chemical Toxicology | 2016 | 37 Pages |
Abstract
Oily fish, a source of long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs), may contain persistent organic pollutants (POPs), including α-hexabromocyclododecane (α-HBCD). In experimental studies, marine LC n-3 PUFAs ameliorate fatty liver development while HBCD exposure was found to cause liver fatty acid (FA) changes. The present study investigated interactions of FAs and α-HBCD in juvenile female BALB/c mice using a factorial design. Mice (n = 48) were exposed for 28 days to a low (100 μg*kg body weight (BW)â1*dayâ1) or high dose (100 mg*kg BWâ1*dayâ1) of α-HBCD in diets with or without LC n-3 PUFAs. High dose α-HBCD affected whole body lipid metabolism leading to changes in body weight and composition, and pathological changes in hepatic histology, which surprisingly were aggravated by dietary LC n-3 PUFAs. Hepatic FA profiling and gene expression analysis indicated that the dietary modulation of the hepatotoxic response to the high dose of α-HBCD was associated with differential effects on FA β-oxidation. Our results suggest that in a juvenile mouse model, marine FAs accentuate hepatotoxic effects of high dose α-HBCD. This highlights that the background diet is a critical variable in the risk assessment of POPs and warrants further investigation of dietary mediated toxicity of food contaminants.
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Authors
Annette Bernhard, Marc H.G. Berntssen, Anne-Katrine Lundebye, Anita Røyneberg Alvheim, Lene Secher Myrmel, Even Fjære, Bente E. Torstensen, Karsten Kristiansen, Lise Madsen, Trond Brattelid, Josef D. Rasinger,