Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9030594 | Food and Chemical Toxicology | 2005 | 11 Pages |
Abstract
Administration of CaHMB in basal diet for 91 days was tolerated well. There were no unscheduled sacrifices or deaths. There were no CaHMB-related adverse effects on clinical observations, body weights, food consumption, clinical chemistry, hematology, absolute or relative organ weights, or macroscopic or microscopic observations. A statistically significant increase in inorganic phosphorous was observed in male animals in the 5% feeding group; however, this effect was not considered adverse. Based on the results of this study, the no-observed-adverse-effect level (NOAEL) was considered to be 5% of CaHMB mixed with diet (3.49Â g/kg BW for males and 4.16Â g/kg BW for females).
Keywords
FDAEPAGLPNOAELα-ketoisocaproateKICCFRHmbHMG-CoARBCGood Laboratory PracticesEicosapentaenoic acidstandard deviationanalysis of varianceANOVAOralFood and Drug AdministrationToxicityNuclear factor κ BRatNo observed adverse effect levelbody weightCode of Federal RegulationsCreatine phosphokinasehigh performance liquid chromatographyHPLC
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Authors
J.H. Baxter, J.L. Carlos, J. Thurmond, R.N. Rehani, J. Bultman, D. Frost,