Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9903915 | Trends in Food Science & Technology | 2005 | 9 Pages |
Abstract
Folates are essential nutrients for the cell for DNA synthesis. From a nutritional perspective, a high folate status may have a beneficial/protective effect against cancer, birth defects and age-related diseases. However, data presented in this study provide evidence that a high folate status can also have a differential impact on the therapeutic efficacy of both folate-based and other widely used anticancer agents. This study describes the molecular mechanisms underlying these effects, which involve folate influx/efflux proteins, intracellular metabolism and target enzymes.
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Authors
G.J. Peters, J.H. Hooijberg, G.J.L. Kaspers, G. Jansen,