Crystal Structures of T. brucei MRP1/MRP2 Guide-RNA Binding Complex Reveal RNA Matchmaking Mechanism Fulltext Access 11 Pages 2006
Regulatory Functions of Nuclear Hexokinase1 Complex in Glucose Signaling Fulltext Access 11 Pages 2006
Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration Fulltext Access 11 Pages 2006
Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi Fulltext Access 11 Pages 2006
Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival Fulltext Access 11 Pages 2006
Tumor Morphology and Phenotypic Evolution Driven by Selective Pressure from the Microenvironment Fulltext Access 11 Pages 2006
Reciprocal Gut Microbiota Transplants from Zebrafish and Mice to Germ-free Recipients Reveal Host Habitat Selection Fulltext Access 11 Pages 2006
RETRACTED: Role of the Sigma Factor in Transcription Initiation in the Absence of Core RNA Polymerase Fulltext Access 11 Pages 2006
Meiotic Proteins Bqt1 and Bqt2 Tether Telomeres to Form the Bouquet Arrangement of Chromosomes Fulltext Access 11 Pages 2006
Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network Fulltext Access 11 Pages 2006
Functional dissection of human protease μ-calpain in cell migration using RNAi Fulltext Access 11 Pages 2006
Identifying and defusing weapons of mass inflammation in carcinogenesis Fulltext Access 11 Pages 2006
β-catenin-mediated signaling: A novel molecular target for chemoprevention with anti-inflammatory substances Fulltext Access 11 Pages 2006
Decay-accelerating factor (CD55): A versatile acting molecule in human malignancies Fulltext Access 11 Pages 2006
Cross-talk between the sarcoplasmic reticulum and the mitochondrial calcium handling systems may play an important role in the regulation of contraction in anococcygeus smooth muscle Fulltext Access 11 Pages 2006
1,25-Dihydroxyvitamin D3 inhibits tumor necrosis factor-α-induced adhesion molecule expression in endothelial cells Fulltext Access 11 Pages 2006
Differential proliferative response of the ventral prostate and seminal vesicle to testosterone replacement Fulltext Access 11 Pages 2006
Active Ras-induced effects on skeletal myoblast differentiation and apoptosis are independent of constitutive PI3-kinase activity Fulltext Access 11 Pages 2006
Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma Fulltext Access 11 Pages 2006
Oxygen binding and NO scavenging properties of truncated hemoglobin, HbN, of Mycobacterium smegmatis Fulltext Access 11 Pages 2006
Correlation between genomic DNA copy number alterations and transcriptional expression in hepatitis B virus-associated hepatocellular carcinoma Fulltext Access 11 Pages 2006
Cancer-selective induction of cytotoxicity by tissue-specific expression of targeted trans-splicing ribozyme Fulltext Access 11 Pages 2006
Trace amounts of copper induce neurotoxicity in the cholesterol-fed mice through apoptosis Fulltext Access 11 Pages 2006
Altered β-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer’s disease brain Fulltext Access 11 Pages 2006
Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing Fulltext Access 11 Pages 2006
The multidrug resistance-associated protein (MRP/ABCC) subfamily of ATP-binding cassette transporters in plants Fulltext Access 11 Pages 2006
The Tie2 5′ untranslated region is inhibitory to 5′ end-mediated translation initiation Fulltext Access 11 Pages 2006
Transcriptional autoregulation by Mycobacterium tuberculosis PhoP involves recognition of novel direct repeat sequences in the regulatory region of the promoter Fulltext Access 11 Pages 2006
Epidermal sphingolipids: Metabolism, function, and roles in skin disorders Fulltext Access 11 Pages 2006
A Molecular Mousetrap Determines Polarity of Termination of DNA Replication in E. coli Fulltext Access 11 Pages 2006
PIASxα Differentially Regulates the Amplitudes of Transcriptional Responses Following Activation of the ERK and p38 MAPK Pathways Fulltext Access 11 Pages 2006
Crystal Structure of the Mitochondrial Chaperone TIM9•10 Reveals a Six-Bladed α-Propeller Fulltext Access 11 Pages 2006
Sequential ATP Hydrolysis by Cdc6 and ORC Directs Loading of the Mcm2-7 Helicase Fulltext Access 11 Pages 2006
DNA Degradation at Unprotected Telomeres in Yeast Is Regulated by the CDK1 (Cdc28/Clb) Cell-Cycle Kinase Fulltext Access 11 Pages 2006
Vertebrate POLQ and POLβ Cooperate in Base Excision Repair of Oxidative DNA Damage Fulltext Access 11 Pages 2006
Repositioning of the Reaction Intermediate within the Catalytic Center of the Spliceosome Fulltext Access 11 Pages 2006
c-Myc Phosphorylation Is Required for Cellular Response to Oxidative Stress Fulltext Access 11 Pages 2006
Regulation of Yeast NRD1 Expression by Premature Transcription Termination Fulltext Access 11 Pages 2006
Growth Factor Signaling Regulates Elongation of RNA Polymerase I Transcription in Mammals via UBF Phosphorylation and r-Chromatin Remodeling Fulltext Access 11 Pages 2006
The Structural Basis of Cooperative Regulation at an Alternate Genetic Switch Fulltext Access 11 Pages 2006
Elongation Arrest by SecM via a Cascade of Ribosomal RNA Rearrangements Fulltext Access 11 Pages 2006
Transcription Impairment and Cell Migration Defects in Elongator-Depleted Cells: Implication for Familial Dysautonomia Fulltext Access 11 Pages 2006
The Checkpoint Clamp Activates Mec1 Kinase during Initiation of the DNA Damage Checkpoint Fulltext Access 11 Pages 2006
HDAC1 Acetylation Is Linked to Progressive Modulation of Steroid Receptor-Induced Gene Transcription Fulltext Access 11 Pages 2006
Molecular Recognition of Transcriptional Repressor Motifs by the WD Domain of the Groucho/TLE Corepressor Fulltext Access 11 Pages 2006
Cell Cycle and Checkpoint Regulation of Histone H3 K56 Acetylation by Hst3 and Hst4 Fulltext Access 11 Pages 2006
A Basal Promoter Element Recognized by Free RNA Polymerase σ Subunit Determines Promoter Recognition by RNA Polymerase Holoenzyme Fulltext Access 11 Pages 2006
Structural Biology of RNA Polymerase III: Subcomplex C17/25 X-Ray Structure and 11 Subunit Enzyme Model Fulltext Access 11 Pages 2006
Structural Basis for Polypyrimidine Tract Recognition by the Essential Pre-mRNA Splicing Factor U2AF65 Fulltext Access 11 Pages 2006
A Branched Pathway Governing the Activation of a Developmental Transcription Factor by Regulated Intramembrane Proteolysis Fulltext Access 11 Pages 2006
Essential Role for IκB Kinase β in Remodeling Carma1-Bcl10-Malt1 Complexes upon T Cell Activation Fulltext Access 11 Pages 2006
A Mechanism of Nucleotide Misincorporation during Transcription due to Template-Strand Misalignment Fulltext Access 11 Pages 2006
Single-Cell Observations Reveal Intermediate Transcriptional Silencing States Fulltext Access 11 Pages 2006
P-TEFb-Mediated Phosphorylation of hSpt5 C-Terminal Repeats Is Critical for Processive Transcription Elongation Fulltext Access 11 Pages 2006
Unfolding of mRNA Secondary Structure by the Bacterial Translation Initiation Complex Fulltext Access 11 Pages 2006
The Conserved Transmembrane Nucleoporin NDC1 Is Required for Nuclear Pore Complex Assembly in Vertebrate Cells Fulltext Access 11 Pages 2006
Inhibition of Msh6 ATPase Activity by Mispaired DNA Induces a Msh2(ATP)-Msh6(ATP) State Capable of Hydrolysis-Independent Movement along DNA Fulltext Access 11 Pages 2006
Conserved XPB Core Structure and Motifs for DNA Unwinding: Implications for Pathway Selection of Transcription or Excision Repair Fulltext Access 11 Pages 2006
Ca2+ Regulation in the Na+/Ca2+ Exchanger Involves Two Markedly Different Ca2+ Sensors Fulltext Access 11 Pages 2006
Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2 Fulltext Access 11 Pages 2006
The Molecular Basis of Filamin Binding to Integrins and Competition with Talin Fulltext Access 11 Pages 2006
Genomic Association of the Proteasome Demonstrates Overlapping Gene Regulatory Activity with Transcription Factor Substrates Fulltext Access 11 Pages 2006
The Molecular Basis of Vitamin D Receptor and β-Catenin Crossregulation Fulltext Access 11 Pages 2006
XIAP Is a Copper Binding Protein Deregulated in Wilson's Disease and Other Copper Toxicosis Disorders Fulltext Access 11 Pages 2006
Two Functional Modes of a Nuclear Receptor-Recruited Arginine Methyltransferase in Transcriptional Activation Fulltext Access 11 Pages 2006
Nucleocytosolic Acetyl-Coenzyme A Synthetase Is Required for Histone Acetylation and Global Transcription Fulltext Access 11 Pages 2006
How Initiation Factors Maximize the Accuracy of tRNA Selection in Initiation of Bacterial Protein Synthesis Fulltext Access 11 Pages 2006
Cyanobacterial Circadian Pacemaker: Kai Protein Complex Dynamics in the KaiC Phosphorylation Cycle In Vitro Fulltext Access 11 Pages 2006
Nuclear PtdIns5P as a Transducer of Stress Signaling: An In Vivo Role for PIP4Kbeta Fulltext Access 11 Pages 2006
Selective Di- or Trimethylation of Histone H3 Lysine 76 by Two DOT1 Homologs Is Important for Cell Cycle Regulation in Trypanosoma brucei Fulltext Access 11 Pages 2006
RNA Polymerase Pausing Regulates Translation Initiation by Providing Additional Time for TRAP-RNA Interaction Fulltext Access 11 Pages 2006
Crystal Structure of Pseudouridine Synthase RluA: Indirect Sequence Readout through Protein-Induced RNA Structure Fulltext Access 11 Pages 2006
Identification of a Rapid Mammalian Deadenylation-Dependent Decay Pathway and Its Inhibition by a Viral RNA Element Fulltext Access 11 Pages 2006