Crystal Structure of Bacillus anthracis ThiI, a tRNA-modifying Enzyme Containing the Predicted RNA-binding THUMP Domain Fulltext Access 14 Pages 2006
Subcellular Positioning of F Plasmid Mediated by Dynamic Localization of SopA and SopB Fulltext Access 14 Pages 2006
Evidence Supporting a cis-enediol-based Mechanism for Pyrococcus furiosus Phosphoglucose Isomerase Fulltext Access 14 Pages 2006
Desulfovibrio desulfuricans G20 Tetraheme Cytochrome Structure at 1.5 Å and Cytochrome Interaction with Metal Complexes Fulltext Access 14 Pages 2006
Hyaluronan: The Local Solution Conformation Determined by NMR and Computer Modeling is Close to a Contracted Left-handed 4-Fold Helix Fulltext Access 14 Pages 2006
Crystal Structure of Papaya Glutaminyl Cyclase, an Archetype for Plant and Bacterial Glutaminyl Cyclases Fulltext Access 14 Pages 2006
Crucial Roles of Both Flanking Sequences in Silencing of the hilA promoter in Salmonella enterica Fulltext Access 14 Pages 2006
Translocation by T7 RNA Polymerase: A Sensitively Poised Brownian Ratchet Fulltext Access 14 Pages 2006
The Photosynthetic Apparatus of Rhodopseudomonas palustris: Structures and Organization Fulltext Access 14 Pages 2006
Alternate Structural Conformations of Streptococcus pneumoniae Hyaluronan Lyase: Insights into Enzyme Flexibility and Underlying Molecular Mechanism of Action Fulltext Access 14 Pages 2006
Crystal Structure and Structure-based Mutational Analyses of RNase HIII from Bacillus stearothermophilus: A New Type 2 RNase H with TBP-like Substrate-binding Domain at the N Terminus Fulltext Access 14 Pages 2006
Structural Analysis of N-acetylglucosamine-6-phosphate Deacetylase Apoenzyme from Escherichia coli Fulltext Access 14 Pages 2006
Efficient Restraints for Protein–Protein Docking by Comparison of Observed Amino Acid Substitution Patterns with those Predicted from Local Environment Fulltext Access 14 Pages 2006
Refinement of Protein Structures by Iterative Comparative Modeling and CryoEM Density Fitting Fulltext Access 14 Pages 2006
Room to Move: Crystallizing Membrane Proteins in Swollen Lipidic Mesophases Fulltext Access 14 Pages 2006
Discovery and Characterization of a Linear Cyclotide from Viola odorata: Implications for the Processing of Circular Proteins Fulltext Access 14 Pages 2006
RNA-dependent Folding and Stabilization of C5 Protein During Assembly of the E. coli RNase P Holoenzyme Fulltext Access 14 Pages 2006
Evidence that Membrane Insertion of the Cytosolic Domain of Bcl-xL is Governed by an Electrostatic Mechanism Fulltext Access 14 Pages 2006
The Thioesterase Domain of the Fengycin Biosynthesis Cluster: A Structural Base for the Macrocyclization of a Non-ribosomal Lipopeptide Fulltext Access 14 Pages 2006
Solution Structure of the RBCC/TRIM B-box1 Domain of Human MID1: B-box with a RING Fulltext Access 14 Pages 2006
Crystal Structure of the SH3 Domain of βPIX in Complex with a High Affinity Peptide from PAK2 Fulltext Access 14 Pages 2006
The Crystal Structure of TrpD, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate Fulltext Access 14 Pages 2006
Novel approaches for immunotherapeutic intervention in Alzheimer's disease Fulltext Access 14 Pages 2006
Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy Fulltext Access 14 Pages 2006
FGF signaling is necessary for establishing gut tube domains alongthe anterior–posterior axis in vivo Fulltext Access 14 Pages 2006
Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation Fulltext Access 14 Pages 2006
The Drosophila ramshackle gene encodes a chromatin-associated protein required for cell morphology in the developing eye Fulltext Access 14 Pages 2006
Fate map of the distal portion of Drosophila proboscis as inferred from the expression and mutations of basic patterning genes Fulltext Access 14 Pages 2006
Dynamics of a local badger (Meles meles) population in the Netherlands over the years 1983–2001 Fulltext Access 14 Pages 2006
Identification, localization and interaction of SNARE proteins in atrial cardiac myocytes Fulltext Access 14 Pages 2006
Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity Fulltext Access 14 Pages 2006
Ischemia-specific phosphorylation and myofilament translocation of heat shock protein 27 precedes alpha B-crystallin and occurs independently of reactive oxygen species in rabbit myocardium Fulltext Access 14 Pages 2006
A Statistical Analysis of Random Mutagenesis Methods Used for Directed Protein Evolution Fulltext Access 14 Pages 2006
Simultaneous Binding of Three Recognition Sites is Necessary for a Concerted Plasmid DNA Cleavage by EcoRII Restriction Endonuclease Fulltext Access 14 Pages 2006
A Structure-based Proposal for the Catalytic Mechanism of the Bacterial Acid Phosphatase AphA belonging to the DDDD Superfamily of Phosphohydrolases Fulltext Access 14 Pages 2006
Metal Bridges between the PhoQ Sensor Domain and the Membrane Regulate Transmembrane Signaling Fulltext Access 14 Pages 2006
Protein Trans-splicing and Characterization of a Split Family B-type DNA Polymerase from the Hyperthermophilic Archaeal Parasite Nanoarchaeum equitans Fulltext Access 14 Pages 2006
Dynamics and Mechanism of the Tanford Transition of Bovine β-Lactoglobulin Studied using Heteronuclear NMR Spectroscopy Fulltext Access 14 Pages 2006
Retention of Misfolded Mutant Transthyretin by the Chaperone BiP/GRP78 Mitigates Amyloidogenesis Fulltext Access 14 Pages 2006
Kinetics of an Individual Transmembrane Helix during Bacteriorhodopsin Folding Fulltext Access 14 Pages 2006
Communication between Eukaryotic Translation Initiation Factors 5 and 1A within the Ribosomal Pre-initiation Complex Plays a Role in Start Site Selection Fulltext Access 14 Pages 2006
Mutational Analysis of the Catalytic Domain of the Murine Dnmt3a DNA-(cytosine C5)-methyltransferase Fulltext Access 14 Pages 2006
Crystal Structure of Pseudomonas aeruginosa SPM-1 Provides Insights into Variable Zinc Affinity of Metallo-β-lactamases Fulltext Access 14 Pages 2006
Sequence Requirements for Lon-dependent Degradation of the Escherichia coli Transcription Activator SoxS: Identification of the SoxS Residues Critical to Proteolysis and Specific Inhibition of in vitro Degradation by a Peptide Comprised of the N-terminal Fulltext Access 14 Pages 2006
Quaternary Polymorphism of Replicative Helicase G40P: Structural Mapping and Domain Rearrangement Fulltext Access 14 Pages 2006
Multisite Promiscuity in the Processing of Endogenous Substrates by Human Carboxylesterase 1 Fulltext Access 14 Pages 2006
Human TPST1 Transmembrane Domain Triggers Enzyme Dimerisation and Localisation to the Golgi Compartment Fulltext Access 14 Pages 2006
Prolonged Ca2+ and Force Transients in Myosin RLC Transgenic Mouse Fibers Expressing Malignant and Benign FHC Mutations Fulltext Access 14 Pages 2006
An Episulfide Cation (Thiiranium Ring) Trapped in the Active Site of HAV 3C Proteinase Inactivated by Peptide-based Ketone Inhibitors Fulltext Access 14 Pages 2006
DNA Recognition by the Brinker Repressor – An Extreme Case of Coupling Between Binding and Folding Fulltext Access 14 Pages 2006
The Equilibrium Unfolding Intermediate Observed at pH 4 and its Relationship with the Kinetic Folding Intermediates in Green Fluorescent Protein Fulltext Access 14 Pages 2006
Functional and Structural Characterization of a Thiol Peroxidase from Mycobacterium tuberculosis Fulltext Access 14 Pages 2006
Kinetic Folding and Assembly Mechanisms Differ for Two Homologous Heptamers Fulltext Access 14 Pages 2006
Activation of Ubiquitin Ligase SCFSkp2 by Cks1: Insights from Hydrogen Exchange Mass Spectrometry Fulltext Access 14 Pages 2006
Conformational Effects of Gly–X–Gly Interruptions in the Collagen Triple Helix Fulltext Access 14 Pages 2006
A Thiol Labelling Competition Experiment as a Probe for Sidechain Packing in the Kinetic Folding Intermediate of N-PGK Fulltext Access 14 Pages 2006
Directed Evolution of DNA Polymerase, RNA Polymerase and Reverse Transcriptase Activity in a Single Polypeptide Fulltext Access 14 Pages 2006
Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions Fulltext Access 14 Pages 2006
Computational Design of a New Hydrogen Bond Network and at Least a 300-fold Specificity Switch at a Protein−Protein Interface Fulltext Access 14 Pages 2006
A New Model for Schizosaccharomyces pombe Telomere Recognition: The Telomeric Single-stranded DNA-Binding Activity of Pot11-389 Fulltext Access 14 Pages 2006
Oleic Acid Inhibits Amyloid Formation of the Intermediate of α-Lactalbumin at Moderately Acidic pH Fulltext Access 14 Pages 2006
The Paradoxical Behavior of a Highly Structured Misfolded Intermediate in RNA Folding Fulltext Access 14 Pages 2006
Direct Analysis of Backbone–Backbone Hydrogen Bond Formation in Protein Folding Transition States Fulltext Access 14 Pages 2006
Structural Basis of Interaction between Urokinase-type Plasminogen Activator and its Receptor Fulltext Access 14 Pages 2006
Crystal Structures of Human Tissue Kallikrein 4: Activity Modulation by a Specific Zinc Binding Site Fulltext Access 14 Pages 2006
The C2 Domain of PKCα Is a Ca2+-dependent PtdIns(4,5)P2 Sensing Domain: A New Insight into an Old Pathway Fulltext Access 14 Pages 2006
hCLE/CGI-99, a Human Protein that Interacts with the Influenza Virus Polymerase, Is a mRNA Transcription Modulator Fulltext Access 14 Pages 2006
Quasi-symmetry in the Cryo-EM Structure of EmrE Provides the Key to Modeling its Transmembrane Domain Fulltext Access 14 Pages 2006
Improving the Stability of an Antibody Variable Fragment by a Combination of Knowledge-based Approaches: Validation and Mechanisms Fulltext Access 14 Pages 2006
Thermodynamics Reveal that Helix Four in the NLS of NF-κB p65 Anchors IκBα, Forming a Very Stable Complex Fulltext Access 14 Pages 2006
Structural Basis of the Water-assisted Asparagine Recognition by Asparaginyl-tRNA Synthetase Fulltext Access 14 Pages 2006
Two-rung Model of a Left-handed β-Helix for Prions Explains Species Barrier and Strain Variation in Transmissible Spongiform Encephalopathies Fulltext Access 14 Pages 2006
Mapping the Conformation of the Nucleic Acid Framework of the T7 RNA Polymerase Elongation Complex in Solution Using Low-energy CD and Fluorescence Spectroscopy Fulltext Access 14 Pages 2006
The Structure of the RNA m5C Methyltransferase YebU from Escherichia coli Reveals a C-terminal RNA-recruiting PUA Domain Fulltext Access 14 Pages 2006
Identification and Characterization of the Chromatin-binding Domains of the HIV-1 Integrase Interactor LEDGF/p75 Fulltext Access 14 Pages 2006
Mismatch Repair Factor MSH2-MSH3 Binds and Alters the Conformation of Branched DNA Structures Predicted to form During Genetic Recombination Fulltext Access 14 Pages 2006
Following the Dynamics of Changes in Solvent Accessibility of 16 S and 23 S rRNA During Ribosomal Subunit Association Using Synchrotron-generated Hydroxyl Radicals Fulltext Access 14 Pages 2006
Structural and Genomic Properties of the Hyperthermophilic Archaeal Virus ATV with an Extracellular Stage of the Reproductive Cycle Fulltext Access 14 Pages 2006
Interplay between the β′ Clamp and the β′ Jaw Domains during DNA Opening by the Bacterial RNA Polymerase at σ54-dependent Promoters Fulltext Access 14 Pages 2006
Mutational Analysis of σ70 Region 4 Needed for Appropriation by the Bacteriophage T4 Transcription Factors AsiA and MotA Fulltext Access 14 Pages 2006
Chelerythrine and Sanguinarine Dock at Distinct Sites on BclXL that are Not the Classic BH3 Binding Cleft Fulltext Access 14 Pages 2006
A Free Energy Cascade with Locks Drives Assembly and Maturation of Bacteriophage HK97 Capsid Fulltext Access 14 Pages 2006
Mixed Macromolecular Crowding Accelerates the Refolding of Rabbit Muscle Creatine Kinase: Implications for Protein Folding in Physiological Environments Fulltext Access 14 Pages 2006
Heat Shock Protein 70 Inhibits α-Synuclein Fibril Formation via Interactions with Diverse Intermediates Fulltext Access 14 Pages 2006
Structural Basis of the Sulphate Starvation Response in E. coli: Crystal Structure and Mutational Analysis of the Cofactor-binding Domain of the Cbl Transcriptional Regulator Fulltext Access 14 Pages 2006
Luman, a New Partner of HIV-1 TMgp41, Interferes with Tat-mediated Transcription of the HIV-1 LTR Fulltext Access 14 Pages 2006
The Unfolded State of the Villin Headpiece Helical Subdomain: Computational Studies of the Role of Locally Stabilized Structure Fulltext Access 14 Pages 2006
Specificity of the Initial Collapse in the Folding of the Cold Shock Protein Fulltext Access 14 Pages 2006