Structure of a GDP:AlF4 Complex of the SRP GTPases Ffh and FtsY, and Identification of a Peripheral Nucleotide Interaction Site Fulltext Access 13 Pages 2006
Structure of the N-terminal Domain of the FOP (FGFR1OP) Protein and Implications for its Dimerization and Centrosomal Localization Fulltext Access 13 Pages 2006
Insights into Cephamycin Biosynthesis: the Crystal Structure of CmcI from Streptomyces clavuligerus Fulltext Access 13 Pages 2006
Role of Structural and Dynamical Plasticity in Sin3: The Free PAH2 Domain is a Folded Module in mSin3B Fulltext Access 13 Pages 2006
Structural Studies of a Two-domain Chitinase from Streptomyces griseus HUT6037 Fulltext Access 13 Pages 2006
Specific Recognition of HIV TAR RNA by the dsRNA Binding Domains (dsRBD1–dsRBD2) of PKR Fulltext Access 13 Pages 2006
The Component Polypeptide Chains of Bovine Insulin Nucleate or Inhibit Aggregation of the Parent Protein in a Conformation-dependent Manner Fulltext Access 13 Pages 2006
Quantitative Actin Folding Reactions using Yeast CCT Purified via an Internal Tag in the CCT3/γ Subunit Fulltext Access 13 Pages 2006
Solution Structure of the NEAT (NEAr Transporter) Domain from IsdH/HarA: the Human Hemoglobin Receptor in Staphylococcus aureus Fulltext Access 13 Pages 2006
Crystal Structure of Escherichia coliL-Arabinose Isomerase (ECAI), The Putative Target of Biological Tagatose Production Fulltext Access 13 Pages 2006
Interplay Between Ion Binding and Catalysis in the Thioredoxin-coupled Arsenate Reductase Family Fulltext Access 13 Pages 2006
T-rich DNA Single Strands Bind to a Preformed Site on the Bacterial Cold Shock Protein Bs-CspB Fulltext Access 13 Pages 2006
Structural and Kinetic Analysis of Caspase-3 Reveals Role for S5 Binding Site in Substrate Recognition Fulltext Access 13 Pages 2006
Evolutionarily Distinct Residues in the Uncoupling Protein UCP1 Are Essential for Its Characteristic Basal Proton Conductance Fulltext Access 13 Pages 2006
Translocation of a tRNA with an Extended Anticodon Through the Ribosome Fulltext Access 13 Pages 2006
Structural Rearrangements in the Thyroid Hormone Receptor Hinge Domain and Their Putative Role in the Receptor Function Fulltext Access 13 Pages 2006
A Novel Glycoside Hydrolase Family 105: The Structure of Family 105 Unsaturated Rhamnogalacturonyl Hydrolase Complexed with a Disaccharide in Comparison with Family 88 Enzyme Complexed with the Disaccharide Fulltext Access 13 Pages 2006
Monitoring the Diffusion of Single Heterotrimeric G Proteins in Supported Cell-membrane Sheets Reveals their Partitioning into Microdomains Fulltext Access 13 Pages 2006
Evidence that Creation of Invasion Sites Determines the Rate of Strand Transfer Mediated by HIV-1 Reverse Transcriptase Fulltext Access 13 Pages 2006
The Alkali Molten Globule State of Horse Ferricytochrome c: Observation of Cold Denaturation Fulltext Access 13 Pages 2006
Mechanism of Phosphoryl Transfer Catalyzed by Shikimate Kinase from Mycobacterium tuberculosis Fulltext Access 13 Pages 2006
Self-interaction of a SNARE Transmembrane Domain Promotes the Hemifusion-to-fusion Transition Fulltext Access 13 Pages 2006
Crystal Structures of Human NUDT5 Reveal Insights into the Structural Basis of the Substrate Specificity Fulltext Access 13 Pages 2006
The mitochondrion as a primary site of action of steroid and thyroid hormones: Presence and action of steroid and thyroid hormone receptors in mitochondria of animal cells Fulltext Access 13 Pages 2006
Gonadotroph-specific expression of the human follicle stimulating hormone β gene in transgenic mice Fulltext Access 13 Pages 2006
Molecular characterization and sex-related seasonal expression of thyroid receptor subtypes in goldfish Fulltext Access 13 Pages 2006
Somatostatin modulates PI3K-Akt, eNOS and NHE activity in the ciliary epithelium Fulltext Access 13 Pages 2006
Estradiol affects androgen-binding protein expression and fertilizing ability of spermatozoa in adult male rats Fulltext Access 13 Pages 2006
Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1 Fulltext Access 13 Pages 2006
A Rearranging Ligand Enables Allosteric Control of Catalytic Activity in Copper-containing Nitrite Reductase Fulltext Access 13 Pages 2006
The C-terminal TPR Domain of Tom70 Defines a Family of Mitochondrial Protein Import Receptors Found only in Animals and Fungi Fulltext Access 13 Pages 2006
Stimulated Expression of mRNAs in Activated T Cells Depends on a Functional CRM1 Nuclear Export Pathway Fulltext Access 13 Pages 2006
Structural Insights into Enzyme–Substrate Interaction and Characterization of Enzymatic Intermediates of Organic Hydroperoxide Resistance Protein from Xylella fastidiosa Fulltext Access 13 Pages 2006
Structures of Ubiquitin Insertion Mutants Support Site-specific Reflex Response to Insertions Hypothesis Fulltext Access 13 Pages 2006
The First Holocomplex Structure of Ribonucleotide Reductase Gives New Insight into its Mechanism of Action Fulltext Access 13 Pages 2006
Structural Tolerance versus Functional Intolerance to Mutation of Hydrophobic Core Residues Surrounding Cavities in a Parvovirus Capsid Fulltext Access 13 Pages 2006
Structure–Stability–Activity Relationship in Covalently Cross-linked N-Carbamoyl d-Amino acid Amidohydrolase and N-Acylamino acid Racemase Fulltext Access 13 Pages 2006
Crystal Structures of SnoaL2 and AclR: Two Putative Hydroxylases in the Biosynthesis of Aromatic Polyketide Antibiotics Fulltext Access 13 Pages 2006
The N-terminal 12 Residue Long Peptide of HIV gp41 is the Minimal Peptide Sufficient to Induce Significant T-cell-like Membrane Destabilization in Vitro Fulltext Access 13 Pages 2006
The Exocyclic Amine at the RNase P Cleavage Site Contributes to Substrate Binding and Catalysis Fulltext Access 13 Pages 2006
GuHCl and NaCl-dependent Hydrogen Exchange in MerP Reveals a Well-defined Core with an Unusual Exchange Pattern Fulltext Access 13 Pages 2006
Computational Sampling of a Cryptic Drug Binding Site in a Protein Receptor: Explicit Solvent Molecular Dynamics and Inhibitor Docking to p38 MAP Kinase Fulltext Access 13 Pages 2006
The Structure of an Inverting GH43 β-Xylosidase from Geobacillus stearothermophilus with its Substrate Reveals the Role of the Three Catalytic Residues Fulltext Access 13 Pages 2006
Overexpression of Hepatitis C Virus NS5A Protein Induces Chromosome Instability via Mitotic Cell Cycle Dysregulation Fulltext Access 13 Pages 2006
X-ray Crystal Structures of Rabbit N-acetylglucosaminyltransferase I (GnT I) in Complex with Donor Substrate Analogues Fulltext Access 13 Pages 2006
Human Transcription Factors Contain a High Fraction of Intrinsically Disordered Regions Essential for Transcriptional Regulation Fulltext Access 13 Pages 2006
Engineering, Biophysical Characterisation and Binding Properties of a Soluble Mutant form of Annexin A2 Domain IV that Adopts a Partially Folded Conformation Fulltext Access 13 Pages 2006
Dcs2, a Novel Stress-induced Modulator of m7GpppX Pyrophosphatase Activity that Locates to P Bodies Fulltext Access 13 Pages 2006
Characterization of the Reactivity Determinants of a Novel Hairpin Substrate of Yeast RNase III Fulltext Access 13 Pages 2006
Natural Selection for Kinetic Stability Is a Likely Origin of Correlations between Mutational Effects on Protein Energetics and Frequencies of Amino Acid Occurrences in Sequence Alignments Fulltext Access 13 Pages 2006
Iron Incorporation in Streptococcus suis Dps-like Peroxide Resistance Protein Dpr Requires Mobility in the Ferroxidase Center and Leads to the Formation of a Ferrihydrite-like Core Fulltext Access 13 Pages 2006
Allosteric Communication Network in the Tetrameric Restriction Endonuclease Bse634I Fulltext Access 13 Pages 2006
PARP-1 Interaction with VP1 Capsid Protein Regulates Polyomavirus Early Gene Expression†† Fulltext Access 13 Pages 2006
P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1 Fulltext Access 13 Pages 2006
PKCη is localized in the Golgi, ER and nuclear envelope and translocates to the nuclear envelope upon PMA activation and serum-starvation: Fulltext Access 13 Pages 2006
Functional mapping and identification of novel regulators for the Toll/Interleukin-1 signalling network by transcription expression cloning Fulltext Access 13 Pages 2006
CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2 Fulltext Access 13 Pages 2006
Death or survival: Membrane ceramide controls the fate and activation of antigen-specific T-cells depending on signal strength and duration Fulltext Access 13 Pages 2006
EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing Fulltext Access 13 Pages 2006
TGF-β regulates differentially the proliferation of fetal and adult human skin fibroblasts via the activation of PKA and the autocrine action of FGF-2 Fulltext Access 13 Pages 2006
Role of c-KIT expression level and phosphatidylinositol 3-kinase activation in survival and proliferative responses of early myeloid cells Fulltext Access 13 Pages 2006
RGS proteins have a signalling complex: Interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins Fulltext Access 13 Pages 2006
Activation of Gab1 in pancreatic acinar cells: Effects of gastrointestinal growth factors/hormones on stimulation, phosphospecific phosphorylation, translocation and interaction with downstream signaling molecules Fulltext Access 13 Pages 2006
The membranotropic regions of the endo and ecto domains of HIV gp41 envelope glycoprotein Fulltext Access 13 Pages 2006
Insights into the molecular mechanism of action of Celastraceae sesquiterpenes as specific, non-transported inhibitors of human P-glycoprotein Fulltext Access 13 Pages 2006
Molecular mechanisms of aquaporin biogenesis by the endoplasmic reticulum Sec61 translocon Fulltext Access 13 Pages 2006
A Tandem of SH3-like Domains Participates in RNA Binding in KIN17, a Human Protein Activated in Response to Genotoxics Fulltext Access 13 Pages 2006
Characterization of the Functional Domains of Escherichia coli RNase II Fulltext Access 13 Pages 2006
Simulations of the Myosin II Motor Reveal a Nucleotide-state Sensing Element that Controls the Recovery Stroke Fulltext Access 13 Pages 2006
Structural Classification and Prediction of Reentrant Regions in α-Helical Transmembrane Proteins: Application to Complete Genomes Fulltext Access 13 Pages 2006
Transcriptional Response of Candida albicans to Hypoxia: Linkage of Oxygen Sensing and Efg1p-regulatory Networks Fulltext Access 13 Pages 2006
Crystal Structure and Nucleotide Binding of the Thermus thermophilus RNA Helicase Hera N-terminal Domain Fulltext Access 13 Pages 2006
Amino-terminal Domain Stability Mediates Apolipoprotein E Aggregation into Neurotoxic Fibrils Fulltext Access 13 Pages 2006
Discoidin Domain Receptor 2 Inhibits Fibrillogenesis of Collagen Type 1 Fulltext Access 13 Pages 2006
blm3-1 Is an Allele of UBP3, a Ubiquitin Protease that Appears to Act During Transcription of Damaged DNA Fulltext Access 13 Pages 2006
Suppression of HIV-1 Protease Inhibitor Resistance by Phosphonate-mediated Solvent Anchoring Fulltext Access 13 Pages 2006
Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI Fulltext Access 13 Pages 2006
Crystal Structure and Mechanism of Tripeptidyl Activity of Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis Fulltext Access 13 Pages 2006
Conditions affecting the re-alignment of the antimicrobial peptide PGLa in membranes as monitored by solid state 2H-NMR Fulltext Access 13 Pages 2006
SOS Repair and DNA Supercoiling Influence the Genetic Stability of DNA Triplet Repeats in Escherichia coli Fulltext Access 13 Pages 2006
Selective Binding of Meiosis-specific Yeast Hop1 Protein to the Holliday Junctions Distorts the DNA Structure and Its Implications for Junction Migration and Resolution Fulltext Access 13 Pages 2006
Structure of Leishmania mexicana Phosphomannomutase Highlights Similarities with Human Isoforms Fulltext Access 13 Pages 2006
NMR-based Model Reveals the Structural Determinants of Mammalian Arylamine N-Acetyltransferase Substrate Specificity Fulltext Access 13 Pages 2006
Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114 Fulltext Access 13 Pages 2006
PAS Domain Allostery and Light-induced Conformational Changes in Photoactive Yellow Protein upon I2 Intermediate Formation, Probed with Enhanced Hydrogen/Deuterium Exchange Mass Spectrometry Fulltext Access 13 Pages 2006
Xenobiotic Reductase A in the Degradation of Quinoline by Pseudomonas putida 86: Physiological Function, Structure and Mechanism of 8-Hydroxycoumarin Reduction Fulltext Access 13 Pages 2006
The Structure of Bovine Complement Component 3 Reveals the Basis for Thioester Function Fulltext Access 13 Pages 2006
Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition Fulltext Access 13 Pages 2006
Translation Initiation Factor IF2 Interacts with the 30 S Ribosomal Subunit via Two Separate Binding Sites Fulltext Access 13 Pages 2006
Sequence Motifs and Antimotifs in β-Barrel Membrane Proteins from a Genome-Wide Analysis: The Ala-Tyr Dichotomy and Chaperone Binding Motifs Fulltext Access 13 Pages 2006