A Neuronal Identity Code for the Odorant Receptor-Specific and Activity-Dependent Axon Sorting Fulltext Access 13 Pages 2006
Two different stages of epidermal growth factor (EGF) receptor endocytosis are sensitive to free ubiquitin depletion produced by proteasome inhibitor MG132 Fulltext Access 13 Pages 2006
αII-Spectrin interacts with five groups of functionally important proteins in the nucleus Fulltext Access 13 Pages 2006
Modulation of the epithelial barrier by dexamethasone and prolactin in cultured Madin-Darby canine kidney (MDCK) cells Fulltext Access 13 Pages 2006
Visualization of the chromosome scaffold and intermediates of loop domain compaction in extracted mitotic cells Fulltext Access 13 Pages 2006
Crystal Structures of a Ligand-free MthK Gating Ring: Insights into the Ligand Gating Mechanism of K+ Channels Fulltext Access 13 Pages 2006
The RCK Domain of the KtrAB K+ Transporter: Multiple Conformations of an Octameric Ring Fulltext Access 13 Pages 2006
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells Fulltext Access 13 Pages 2006
Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements Fulltext Access 13 Pages 2006
Cytokine Gene Expression in Peripheral Blood Mononuclear Cells and Alloreactivity in Hematopoietic Cell Transplantation with Nonmyeloablative Conditioning Fulltext Access 13 Pages 2006
p120-Catenin and p190RhoGAP Regulate Cell-Cell Adhesion by Coordinating Antagonism between Rac and Rho Fulltext Access 13 Pages 2006
Mitochondrial Inner-Membrane Fusion and Crista Maintenance Requires the Dynamin-Related GTPase Mgm1 Fulltext Access 13 Pages 2006
Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins Fulltext Access 13 Pages 2006
Otoferlin, Defective in a Human Deafness Form, Is Essential for Exocytosis at the Auditory Ribbon Synapse Fulltext Access 13 Pages 2006
ESCRT-I Core and ESCRT-II GLUE Domain Structures Reveal Role for GLUE in Linking to ESCRT-I and Membranes Fulltext Access 13 Pages 2006
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors Fulltext Access 13 Pages 2006
Ubiquitin Chains Are Remodeled at the Proteasome by Opposing Ubiquitin Ligase and Deubiquitinating Activities Fulltext Access 13 Pages 2006
Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair Fulltext Access 13 Pages 2006
Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2 Fulltext Access 13 Pages 2006
Endothelial cell responses towards low-fouling surfaces bearing RGD in a three-dimensional environment Fulltext Access 13 Pages 2006
The ascidian homolog of the vertebrate homeobox gene Rx is essential for ocellus development and function Fulltext Access 13 Pages 2006
Disruption of the ifkA and ifkB genes results in altered cell adhesion, morphological defects and a propensity to form pre-stalk O cells during development of Dictyostelium Fulltext Access 13 Pages 2006
Transforming growth factor-β signaling helps specify tumor type in DMBA and hormone-induced mammary cancers Fulltext Access 13 Pages 2006
High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients Fulltext Access 13 Pages 2006
A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network Fulltext Access 13 Pages 2006
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines Fulltext Access 13 Pages 2006
BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer Fulltext Access 13 Pages 2006
Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment Fulltext Access 13 Pages 2006
The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells Fulltext Access 13 Pages 2006
ATAXIN-1 Interacts with the Repressor Capicua in Its Native Complex to Cause SCA1 Neuropathology Fulltext Access 13 Pages 2006
ILEI: A cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells Fulltext Access 13 Pages 2006
Targeting β2-microglobulin for induction of tumor apoptosis in human hematological malignancies Fulltext Access 13 Pages 2006
p53 family members in myogenic differentiation and rhabdomyosarcoma development Fulltext Access 13 Pages 2006
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis Fulltext Access 13 Pages 2006
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies Fulltext Access 13 Pages 2006
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes Fulltext Access 13 Pages 2006
Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer Fulltext Access 13 Pages 2006
Pretransplantation Consolidation Chemotherapy Decreases Leukemia Relapse after Autologous Blood and Bone Marrow Transplants for Acute Myelogenous Leukemia in First Remission Fulltext Access 13 Pages 2006
RNA Loading of Leukemic Antigens into Cord Blood–Derived Dendritic Cells for Immunotherapy Fulltext Access 13 Pages 2006
Role of Allogeneic Stem Cell Transplantation for Adult Chronic Myeloid Leukemia in the Imatinib Era Fulltext Access 13 Pages 2006
A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA Fulltext Access 13 Pages 2006
A Genome-Wide Analysis Indicates that Yeast Pre-mRNA Splicing Is Predominantly Posttranscriptional Fulltext Access 13 Pages 2006
Differential Recruitment of the Splicing Machinery during Transcription Predicts Genome-Wide Patterns of mRNA Splicing Fulltext Access 13 Pages 2006
Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis Fulltext Access 13 Pages 2006
Initiation and Beyond: Multiple Functions of the Human Mitochondrial Transcription Machinery Fulltext Access 13 Pages 2006
Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV Lesions Fulltext Access 13 Pages 2006
Cdc7-Dbf4 Phosphorylates MCM Proteins via a Docking Site-Mediated Mechanism to Promote S Phase Progression Fulltext Access 13 Pages 2006
Phosphorylation-Dependent Control of Pc2 SUMO E3 Ligase Activity by Its Substrate Protein HIPK2 Fulltext Access 13 Pages 2006
Spatiotemporal Regulation of c-Fos by ERK5 and the E3 Ubiquitin Ligase UBR1, and Its Biological Role Fulltext Access 13 Pages 2006
Identification of the TRiC/CCT Substrate Binding Sites Uncovers the Function of Subunit Diversity in Eukaryotic Chaperonins Fulltext Access 13 Pages 2006
Structural and Mechanistic Insights into Ras Association Domains of Phospholipase C Epsilon Fulltext Access 13 Pages 2006
A Short Mitochondrial Form of p19ARF Induces Autophagy and Caspase-Independent Cell Death Fulltext Access 13 Pages 2006
RNAi Screen in Mouse Astrocytes Identifies Phosphatases that Regulate NF-κB Signaling Fulltext Access 13 Pages 2006
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt Fulltext Access 13 Pages 2006
Induction of interleukin-8 secretion and activation of ERK1/2, p38 MAPK signaling pathways by thrombin in dermal fibroblasts Fulltext Access 13 Pages 2006
High levels of antioxidant enzymatic defence assure good protection against hypoxic stress in spontaneously diabetic rats Fulltext Access 13 Pages 2006
Different roles of protein kinase C-βI and -δ in the regulation of adipocyte differentiation Fulltext Access 13 Pages 2006
Detection and localization of calpain 3-like protease in a neuronal cell line: Possible regulation of apoptotic cell death through degradation of nuclear IκBα Fulltext Access 13 Pages 2006
Overexpression of the novel human gene, nuclear apoptosis-inducing factor 1, induces apoptosis Fulltext Access 13 Pages 2006
Nucleotide specificity of Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase: Kinetics, fluorescence spectroscopy, and molecular simulation studies Fulltext Access 13 Pages 2006
C-36 peptide, a degradation product of α1-antitrypsin, modulates human monocyte activation through LPS signaling pathways Fulltext Access 13 Pages 2006
Regulation of guanylyl cyclase by intracellular Ca2+ in relation to the infectivity of the protozoan parasite, Leishmania donovani Fulltext Access 13 Pages 2006
Cyclic AMP stimulates MEG3 gene expression in cells through a cAMP-response element (CRE) in the MEG3 proximal promoter region Fulltext Access 13 Pages 2006
Fatty acid elongases in mammals: Their regulation and roles in metabolism Fulltext Access 13 Pages 2006
KIF4 Motor Regulates Activity-Dependent Neuronal Survival by Suppressing PARP-1 Enzymatic Activity Fulltext Access 13 Pages 2006
Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells Fulltext Access 13 Pages 2006
Activation of the Phosphatidylinositol 3-Kinase Vps34 by a G Protein α Subunit at the Endosome Fulltext Access 13 Pages 2006
OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion Fulltext Access 13 Pages 2006
Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling Fulltext Access 13 Pages 2006
Suppression of anti-cancer immunity by regulatory T cells: Back to the future Fulltext Access 13 Pages 2006
The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer Fulltext Access 13 Pages 2006
Myeloid suppressor cells in cancer: Recruitment, phenotype, properties, and mechanisms of immune suppression Fulltext Access 13 Pages 2006
Immune suppression in cancer: Effects on immune cells, mechanisms and future therapeutic intervention Fulltext Access 13 Pages 2006
A role for the cytoskeleton in STAT5 activation in MCF7 human breast cancer cells stimulated with EGF Fulltext Access 13 Pages 2006
Chromosomal Association of the Smc5/6 Complex Reveals that It Functions in Differently Regulated Pathways Fulltext Access 13 Pages 2006
Nuclear Pore Components Are Involved in the Transcriptional Regulation of Dosage Compensation in Drosophila Fulltext Access 13 Pages 2006
Role for CED-9 and Egl-1 as Regulators of Mitochondrial Fission and Fusion Dynamics Fulltext Access 13 Pages 2006
Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO Fulltext Access 13 Pages 2006
A Family of Diverse Cul4-Ddb1-Interacting Proteins Includes Cdt2, which Is Required for S Phase Destruction of the Replication Factor Cdt1 Fulltext Access 13 Pages 2006
Nuclear Retention of the Tumor Suppressor cPML by the Homeodomain Protein TGIF Restricts TGF-β Signaling Fulltext Access 13 Pages 2006
Identification of Early Intermediates of Caspase Activation Using Selective Inhibitors and Activity-Based Probes Fulltext Access 13 Pages 2006