RNA Ligase Structures Reveal the Basis for RNA Specificity and Conformational Changes that Drive Ligation Forward Fulltext Access 14 Pages 2006
A Protein Kinase, Interacting with Two Calcineurin B-like Proteins, Regulates K+ Transporter AKT1 in Arabidopsis Fulltext Access 14 Pages 2006
Intracellular Nucleotides Act as Critical Prosurvival Factors by Binding to Cytochrome C and Inhibiting Apoptosome Fulltext Access 14 Pages 2006
The Pattern of Gene Amplification Is Determined by the Chromosomal Location of Hairpin-Capped Breaks Fulltext Access 14 Pages 2006
Ubiquitin Hydrolase Uch-L1 Rescues β-Amyloid-Induced Decreases in Synaptic Function and Contextual Memory Fulltext Access 14 Pages 2006
ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation Fulltext Access 14 Pages 2006
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors Fulltext Access 14 Pages 2006
Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks Fulltext Access 14 Pages 2006
The BRCA1/BARD1 Heterodimer Modulates Ran-Dependent Mitotic Spindle Assembly Fulltext Access 14 Pages 2006
Ubc9- and Mms21-Mediated Sumoylation Counteracts Recombinogenic Events at Damaged Replication Forks Fulltext Access 14 Pages 2006
Increased Ethanol Resistance and Consumption in Eps8 Knockout Mice Correlates with Altered Actin Dynamics Fulltext Access 14 Pages 2006
RalB GTPase-Mediated Activation of the IκB Family Kinase TBK1 Couples Innate Immune Signaling to Tumor Cell Survival Fulltext Access 14 Pages 2006
Spatiotemporal Feedback between Actomyosin and Focal-Adhesion Systems Optimizes Rapid Cell Migration Fulltext Access 14 Pages 2006
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth Fulltext Access 14 Pages 2006
SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells Fulltext Access 14 Pages 2006
Developmental Origin of a Bipotential Myocardial and Smooth Muscle Cell Precursor in the Mammalian Heart Fulltext Access 14 Pages 2006
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α Fulltext Access 14 Pages 2006
The Architecture of the Multisubunit TRAPP I Complex Suggests a Model for Vesicle Tethering Fulltext Access 14 Pages 2006
E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation Fulltext Access 14 Pages 2006
Ligand-Induced Asymmetry in Histidine Sensor Kinase Complex Regulates Quorum Sensing Fulltext Access 14 Pages 2006
Kinetochore Microtubule Dynamics and Attachment Stability Are Regulated by Hec1 Fulltext Access 14 Pages 2006
Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis Fulltext Access 14 Pages 2006
Gradients of the Drosophila Chinmo BTB-Zinc Finger Protein Govern Neuronal Temporal Identity Fulltext Access 14 Pages 2006
Downregulation of PP2ACdc55 Phosphatase by Separase Initiates Mitotic Exit in Budding Yeast Fulltext Access 14 Pages 2006
Systems Analyses Reveal Two Chaperone Networks with Distinct Functions in Eukaryotic Cells Fulltext Access 14 Pages 2006
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents Fulltext Access 14 Pages 2006
Type II Cadherin Ectodomain Structures: Implications for Classical Cadherin Specificity Fulltext Access 14 Pages 2006
A Genome-Wide Screen Identifies the Evolutionarily Conserved KEOPS Complex as a Telomere Regulator Fulltext Access 14 Pages 2006
The LDL Receptor-Related Protein LRP6 Mediates Internalization and Lethality of Anthrax Toxin Fulltext Access 14 Pages 2006
A Protein–Protein Interaction Network for Human Inherited Ataxias and Disorders of Purkinje Cell Degeneration Fulltext Access 14 Pages 2006
Nontranscriptional Regulation of SYK by the Coactivator OCA-B Is Required at Multiple Stages of B Cell Development Fulltext Access 14 Pages 2006
Redox Regulation Facilitates Optimal Peptide Selection by MHC Class I during Antigen Processing Fulltext Access 14 Pages 2006
Germ-Cell Loss Extends C. elegans Life Span through Regulation of DAF-16 by kri-1 and Lipophilic-Hormone Signaling Fulltext Access 14 Pages 2006
Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress Fulltext Access 14 Pages 2006
rRNA Promoter Regulation by Nonoptimal Binding of σ Region 1.2: An Additional Recognition Element for RNA Polymerase Fulltext Access 14 Pages 2006
Drosophila IKK-Related Kinase Regulates Nonapoptotic Function of Caspases via Degradation of IAPs Fulltext Access 14 Pages 2006
A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response Fulltext Access 14 Pages 2006
In Vivo Two-Photon Imaging Reveals a Role of Arc in Enhancing Orientation Specificity in Visual Cortex Fulltext Access 14 Pages 2006
Histone Deacetylase 7 Maintains Vascular Integrity by Repressing Matrix Metalloproteinase 10 Fulltext Access 14 Pages 2006
Photochemistry of the [Fe4(μ3-S)3(NO)7]− complex in the presence of S-nucleophiles: A spectroscopic study Fulltext Access 14 Pages 2006
Nitroxidation, nitration, and oxidation of a BODIPY fluorophore by RNOS and ROS Fulltext Access 14 Pages 2006
Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing Fulltext Access 14 Pages 2006
Expression in blood cells may contribute to biochemical and pathological improvements after neonatal intravenous gene therapy for mucopolysaccharidosis VII in dogs Fulltext Access 14 Pages 2006
H2AX Prevents DNA Breaks from Progressing to Chromosome Breaks and Translocations Fulltext Access 14 Pages 2006
MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals Fulltext Access 14 Pages 2006
A Phosphatase Holoenzyme Comprised of Shoc2/Sur8 and the Catalytic Subunit of PP1 Functions as an M-Ras Effector to Modulate Raf Activity Fulltext Access 14 Pages 2006
Genome-Wide Location of the Coactivator Mediator: Binding without Activation and Transient Cdk8 Interaction on DNA Fulltext Access 14 Pages 2006
Raf Kinase Inhibitory Protein Regulates Aurora B Kinase and the Spindle Checkpoint Fulltext Access 14 Pages 2006
On the potential of thioredoxin reductase inhibitors for cancer therapy Fulltext Access 14 Pages 2006
Changes in oestrogen receptor-α and -β during progression to acquired resistance to tamoxifen and fulvestrant (Faslodex, ICI 182,780) in MCF7 human breast cancer cells Fulltext Access 14 Pages 2006
Improved anti-tumoral capacity of mixed and pure anti-oestrogens in breast cancer cell xenografts after their administration by entrapment in colloidal nanosystems Fulltext Access 14 Pages 2006
Modeling of farnesyltransferase inhibition by some thiol and non-thiol peptidomimetic inhibitors using genetic neural networks and RDF approaches Fulltext Access 14 Pages 2006
Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies Fulltext Access 14 Pages 2006
Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles Fulltext Access 14 Pages 2006
Optimized design and synthesis of chemical dimerizer substrates for detection of glycosynthase activity via chemical complementation Fulltext Access 14 Pages 2006
Hydrophilically enhanced 3-carboranyl thymidine analogues (3CTAs) for boron neutron capture therapy (BNCT) of cancer Fulltext Access 14 Pages 2006
2-Pyridin-2-yl-1H-indole derivatives: Synthesis, estrogen receptor binding affinity, and photophysical properties Fulltext Access 14 Pages 2006
Direct crystallographic observation of an acyl-enzyme intermediate in the elastase-catalyzed hydrolysis of a peptidyl ester substrate: Exploiting the “glass transition” in protein dynamics Fulltext Access 14 Pages 2006
NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells Fulltext Access 14 Pages 2006
The Structure of the ζζ Transmembrane Dimer Reveals Features Essential for Its Assembly with the T Cell Receptor Fulltext Access 14 Pages 2006
CRTAP Is Required for Prolyl 3- Hydroxylation and Mutations Cause Recessive Osteogenesis Imperfecta Fulltext Access 14 Pages 2006
Global Survey of Organ and Organelle Protein Expression in Mouse: Combined Proteomic and Transcriptomic Profiling Fulltext Access 14 Pages 2006
Structural and Functional Organization of the ESCRT-I Trafficking Complex Fulltext Access 14 Pages 2006
The NoCut Pathway Links Completion of Cytokinesis to Spindle Midzone Function to Prevent Chromosome Breakage Fulltext Access 14 Pages 2006
Target-Induced Transcriptional Control of Dendritic Patterning and Connectivity in Motor Neurons by the ETS Gene Pea3 Fulltext Access 14 Pages 2006
The Proteasome Restricts Permissive Transcription at Tissue-Specific Gene Loci in Embryonic Stem Cells Fulltext Access 14 Pages 2006
A Hybrid Vector for Ligand-Directed Tumor Targeting and Molecular Imaging Fulltext Access 14 Pages 2006
Structural Basis for RNA Unwinding by the DEAD-Box Protein Drosophila Vasa Fulltext Access 14 Pages 2006
Toxoplasma gondii Sequesters Lysosomes from Mammalian Hosts in the Vacuolar Space Fulltext Access 14 Pages 2006
Synthesis with good enantiomeric excess of both enantiomers of α-ketols and acetolactates by two thiamin diphosphate-dependent decarboxylases Fulltext Access 14 Pages 2006
An ARGONAUTE4-Containing Nuclear Processing Center Colocalized with Cajal Bodies in Arabidopsis thaliana Fulltext Access 14 Pages 2006
The Arabidopsis Chromatin-Modifying Nuclear siRNA Pathway Involves a Nucleolar RNA Processing Center Fulltext Access 14 Pages 2006
Pot1 Deficiency Initiates DNA Damage Checkpoint Activation and Aberrant Homologous Recombination at Telomeres Fulltext Access 14 Pages 2006
Structural Model of the mAb 806-EGFR Complex Using Computational Docking followed by Computational and Experimental Mutagenesis Fulltext Access 14 Pages 2006
Sequence and Structure Analysis of Parallel β Helices: Implication for Constructing Amyloid Structural Models Fulltext Access 14 Pages 2006
Single-Molecule Approaches Reveal the Idiosyncrasies of RNA Polymerases Fulltext Access 14 Pages 2006
Prostate cancer cell type-specific involvement of the VDR and RXR in regulation of the human PTHrP gene via a negative VDRE Fulltext Access 14 Pages 2006
Estrogen conjugation and antibody binding interactions in surface plasmon resonance biosensing Fulltext Access 14 Pages 2006