Crystal Structure and Mechanism of Tripeptidyl Activity of Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis Fulltext Access 13 Pages 2006
Structural Tolerance versus Functional Intolerance to Mutation of Hydrophobic Core Residues Surrounding Cavities in a Parvovirus Capsid Fulltext Access 13 Pages 2006
Characterization of the Functional Domains of Escherichia coli RNase II Fulltext Access 13 Pages 2006
Simulations of the Myosin II Motor Reveal a Nucleotide-state Sensing Element that Controls the Recovery Stroke Fulltext Access 13 Pages 2006
Structural Classification and Prediction of Reentrant Regions in α-Helical Transmembrane Proteins: Application to Complete Genomes Fulltext Access 13 Pages 2006
Transcriptional Response of Candida albicans to Hypoxia: Linkage of Oxygen Sensing and Efg1p-regulatory Networks Fulltext Access 13 Pages 2006
Crystal Structure and Nucleotide Binding of the Thermus thermophilus RNA Helicase Hera N-terminal Domain Fulltext Access 13 Pages 2006
Amino-terminal Domain Stability Mediates Apolipoprotein E Aggregation into Neurotoxic Fibrils Fulltext Access 13 Pages 2006
Discoidin Domain Receptor 2 Inhibits Fibrillogenesis of Collagen Type 1 Fulltext Access 13 Pages 2006
blm3-1 Is an Allele of UBP3, a Ubiquitin Protease that Appears to Act During Transcription of Damaged DNA Fulltext Access 13 Pages 2006
Suppression of HIV-1 Protease Inhibitor Resistance by Phosphonate-mediated Solvent Anchoring Fulltext Access 13 Pages 2006
Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI Fulltext Access 13 Pages 2006
Crystal Structures of Human NUDT5 Reveal Insights into the Structural Basis of the Substrate Specificity Fulltext Access 13 Pages 2006
A Tandem of SH3-like Domains Participates in RNA Binding in KIN17, a Human Protein Activated in Response to Genotoxics Fulltext Access 13 Pages 2006
SOS Repair and DNA Supercoiling Influence the Genetic Stability of DNA Triplet Repeats in Escherichia coli Fulltext Access 13 Pages 2006
Selective Binding of Meiosis-specific Yeast Hop1 Protein to the Holliday Junctions Distorts the DNA Structure and Its Implications for Junction Migration and Resolution Fulltext Access 13 Pages 2006
Structure of Leishmania mexicana Phosphomannomutase Highlights Similarities with Human Isoforms Fulltext Access 13 Pages 2006
NMR-based Model Reveals the Structural Determinants of Mammalian Arylamine N-Acetyltransferase Substrate Specificity Fulltext Access 13 Pages 2006
Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114 Fulltext Access 13 Pages 2006
PAS Domain Allostery and Light-induced Conformational Changes in Photoactive Yellow Protein upon I2 Intermediate Formation, Probed with Enhanced Hydrogen/Deuterium Exchange Mass Spectrometry Fulltext Access 13 Pages 2006
Xenobiotic Reductase A in the Degradation of Quinoline by Pseudomonas putida 86: Physiological Function, Structure and Mechanism of 8-Hydroxycoumarin Reduction Fulltext Access 13 Pages 2006
The Structure of Bovine Complement Component 3 Reveals the Basis for Thioester Function Fulltext Access 13 Pages 2006
Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition Fulltext Access 13 Pages 2006
Translation Initiation Factor IF2 Interacts with the 30 S Ribosomal Subunit via Two Separate Binding Sites Fulltext Access 13 Pages 2006
Structural and Kinetic Analysis of Caspase-3 Reveals Role for S5 Binding Site in Substrate Recognition Fulltext Access 13 Pages 2006
Evolutionarily Distinct Residues in the Uncoupling Protein UCP1 Are Essential for Its Characteristic Basal Proton Conductance Fulltext Access 13 Pages 2006
Structure of the N-terminal Domain of the FOP (FGFR1OP) Protein and Implications for its Dimerization and Centrosomal Localization Fulltext Access 13 Pages 2006
Insights into Cephamycin Biosynthesis: the Crystal Structure of CmcI from Streptomyces clavuligerus Fulltext Access 13 Pages 2006
Role of Structural and Dynamical Plasticity in Sin3: The Free PAH2 Domain is a Folded Module in mSin3B Fulltext Access 13 Pages 2006
Structural Studies of a Two-domain Chitinase from Streptomyces griseus HUT6037 Fulltext Access 13 Pages 2006
Specific Recognition of HIV TAR RNA by the dsRNA Binding Domains (dsRBD1–dsRBD2) of PKR Fulltext Access 13 Pages 2006
The Component Polypeptide Chains of Bovine Insulin Nucleate or Inhibit Aggregation of the Parent Protein in a Conformation-dependent Manner Fulltext Access 13 Pages 2006
Quantitative Actin Folding Reactions using Yeast CCT Purified via an Internal Tag in the CCT3/γ Subunit Fulltext Access 13 Pages 2006
Solution Structure of the NEAT (NEAr Transporter) Domain from IsdH/HarA: the Human Hemoglobin Receptor in Staphylococcus aureus Fulltext Access 13 Pages 2006
Crystal Structure of Escherichia coliL-Arabinose Isomerase (ECAI), The Putative Target of Biological Tagatose Production Fulltext Access 13 Pages 2006
Interplay Between Ion Binding and Catalysis in the Thioredoxin-coupled Arsenate Reductase Family Fulltext Access 13 Pages 2006
T-rich DNA Single Strands Bind to a Preformed Site on the Bacterial Cold Shock Protein Bs-CspB Fulltext Access 13 Pages 2006
Sequence Motifs and Antimotifs in β-Barrel Membrane Proteins from a Genome-Wide Analysis: The Ala-Tyr Dichotomy and Chaperone Binding Motifs Fulltext Access 13 Pages 2006
Structure of a GDP:AlF4 Complex of the SRP GTPases Ffh and FtsY, and Identification of a Peripheral Nucleotide Interaction Site Fulltext Access 13 Pages 2006
Translocation of a tRNA with an Extended Anticodon Through the Ribosome Fulltext Access 13 Pages 2006
Structural Rearrangements in the Thyroid Hormone Receptor Hinge Domain and Their Putative Role in the Receptor Function Fulltext Access 13 Pages 2006
A Novel Glycoside Hydrolase Family 105: The Structure of Family 105 Unsaturated Rhamnogalacturonyl Hydrolase Complexed with a Disaccharide in Comparison with Family 88 Enzyme Complexed with the Disaccharide Fulltext Access 13 Pages 2006
Monitoring the Diffusion of Single Heterotrimeric G Proteins in Supported Cell-membrane Sheets Reveals their Partitioning into Microdomains Fulltext Access 13 Pages 2006
Evidence that Creation of Invasion Sites Determines the Rate of Strand Transfer Mediated by HIV-1 Reverse Transcriptase Fulltext Access 13 Pages 2006
The Alkali Molten Globule State of Horse Ferricytochrome c: Observation of Cold Denaturation Fulltext Access 13 Pages 2006
Mechanism of Phosphoryl Transfer Catalyzed by Shikimate Kinase from Mycobacterium tuberculosis Fulltext Access 13 Pages 2006
Self-interaction of a SNARE Transmembrane Domain Promotes the Hemifusion-to-fusion Transition Fulltext Access 13 Pages 2006
Cdc7-Dbf4 Phosphorylates MCM Proteins via a Docking Site-Mediated Mechanism to Promote S Phase Progression Fulltext Access 13 Pages 2006
Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO Fulltext Access 13 Pages 2006
A Family of Diverse Cul4-Ddb1-Interacting Proteins Includes Cdt2, which Is Required for S Phase Destruction of the Replication Factor Cdt1 Fulltext Access 13 Pages 2006
Nuclear Retention of the Tumor Suppressor cPML by the Homeodomain Protein TGIF Restricts TGF-β Signaling Fulltext Access 13 Pages 2006
Identification of Early Intermediates of Caspase Activation Using Selective Inhibitors and Activity-Based Probes Fulltext Access 13 Pages 2006
RNAi Screen in Mouse Astrocytes Identifies Phosphatases that Regulate NF-κB Signaling Fulltext Access 13 Pages 2006
A Genome-Wide Analysis Indicates that Yeast Pre-mRNA Splicing Is Predominantly Posttranscriptional Fulltext Access 13 Pages 2006
Differential Recruitment of the Splicing Machinery during Transcription Predicts Genome-Wide Patterns of mRNA Splicing Fulltext Access 13 Pages 2006
Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis Fulltext Access 13 Pages 2006
Initiation and Beyond: Multiple Functions of the Human Mitochondrial Transcription Machinery Fulltext Access 13 Pages 2006
Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV Lesions Fulltext Access 13 Pages 2006
Phosphorylation-Dependent Control of Pc2 SUMO E3 Ligase Activity by Its Substrate Protein HIPK2 Fulltext Access 13 Pages 2006
Spatiotemporal Regulation of c-Fos by ERK5 and the E3 Ubiquitin Ligase UBR1, and Its Biological Role Fulltext Access 13 Pages 2006
Identification of the TRiC/CCT Substrate Binding Sites Uncovers the Function of Subunit Diversity in Eukaryotic Chaperonins Fulltext Access 13 Pages 2006
Structural and Mechanistic Insights into Ras Association Domains of Phospholipase C Epsilon Fulltext Access 13 Pages 2006
A Short Mitochondrial Form of p19ARF Induces Autophagy and Caspase-Independent Cell Death Fulltext Access 13 Pages 2006
A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA Fulltext Access 13 Pages 2006
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt Fulltext Access 13 Pages 2006
Automated Detection of Elementary Calcium Release Events Using the À Trous Wavelet Transform Fulltext Access 13 Pages 2006
Redesigning Channel-Forming Peptides: Amino Acid Substitutions that Enhance Rates of Supramolecular Self-Assembly and Raise Ion Transport Activity Fulltext Access 13 Pages 2006
Engineering, Biophysical Characterisation and Binding Properties of a Soluble Mutant form of Annexin A2 Domain IV that Adopts a Partially Folded Conformation Fulltext Access 13 Pages 2006
Dcs2, a Novel Stress-induced Modulator of m7GpppX Pyrophosphatase Activity that Locates to P Bodies Fulltext Access 13 Pages 2006
Characterization of the Reactivity Determinants of a Novel Hairpin Substrate of Yeast RNase III Fulltext Access 13 Pages 2006
Natural Selection for Kinetic Stability Is a Likely Origin of Correlations between Mutational Effects on Protein Energetics and Frequencies of Amino Acid Occurrences in Sequence Alignments Fulltext Access 13 Pages 2006
Iron Incorporation in Streptococcus suis Dps-like Peroxide Resistance Protein Dpr Requires Mobility in the Ferroxidase Center and Leads to the Formation of a Ferrihydrite-like Core Fulltext Access 13 Pages 2006
Allosteric Communication Network in the Tetrameric Restriction Endonuclease Bse634I Fulltext Access 13 Pages 2006
PARP-1 Interaction with VP1 Capsid Protein Regulates Polyomavirus Early Gene Expression†† Fulltext Access 13 Pages 2006
Species-specific cell–matrix interactions are essential for differentiation of alveoli like structures and milk gene expression in primary mammary cells of the Cape fur seal (Arctocephalus pusillus pusillus) Fulltext Access 13 Pages 2006
Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation Fulltext Access 13 Pages 2006
Sequences and domain structures of mammalian, avian, amphibian and teleost tropoelastins: Clues to the evolutionary history of elastins Fulltext Access 13 Pages 2006
Regulation of serine protease inhibitor-E2 and plasminogen activator expression and secretion by follicle stimulating hormone and growth factors in non-luteinizing bovine granulosa cells in vitro Fulltext Access 13 Pages 2006
SNARE-Mediated Lipid Mixing Depends on the Physical State of the Vesicles Fulltext Access 13 Pages 2006
Molecular Dynamics Simulations of the Complete Satellite Tobacco Mosaic Virus Fulltext Access 13 Pages 2006
Solution Structures of the SURP Domains and the Subunit-Assembly Mechanism within the Splicing Factor SF3a Complex in 17S U2 snRNP Fulltext Access 13 Pages 2006
Pathways and Kinetic Barriers in Mechanical Unfolding and Refolding of RNA and Proteins Fulltext Access 13 Pages 2006
Crystal Structures of U8 snoRNA Decapping Nudix Hydrolase, X29, and Its Metal and Cap Complexes Fulltext Access 13 Pages 2006
Mechanism of Gating and Ion Conductivity of a Possible Tetrameric Pore in Aquaporin-1 Fulltext Access 13 Pages 2006
Chromosomal Association of the Smc5/6 Complex Reveals that It Functions in Differently Regulated Pathways Fulltext Access 13 Pages 2006
Nuclear Pore Components Are Involved in the Transcriptional Regulation of Dosage Compensation in Drosophila Fulltext Access 13 Pages 2006
Role for CED-9 and Egl-1 as Regulators of Mitochondrial Fission and Fusion Dynamics Fulltext Access 13 Pages 2006