Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of α4β2 nicotinic acetylcholine receptors (α4β2-nAChRs) in the brain with positron emission tomography Fulltext Access 11 Pages 2009
Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3β (GSK-3β) inhibitors Fulltext Access 11 Pages 2009
Relationships between the structure of 6-substituted 6,8-diazabicyclo[3.2.2]nonan-2-ones and their σ receptor affinity and cytotoxic activity Fulltext Access 11 Pages 2009
Identification and characterization of novel sirtuin inhibitor scaffolds Fulltext Access 11 Pages 2009
Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors Fulltext Access 11 Pages 2009
Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria Fulltext Access 11 Pages 2009
Design, synthesis and biological evaluation of tripeptide boronic acid proteasome inhibitors Fulltext Access 11 Pages 2009
Effect of 3,4-ethylenedioxy-extension of thiophene core on the DNA/RNA binding properties and biological activity of bisbenzimidazole amidines Fulltext Access 11 Pages 2009
Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action Fulltext Access 11 Pages 2009
N-Terminal 2,3-diaminopropionic acid (Dap) peptides as efficient methylglyoxal scavengers to inhibit advanced glycation endproduct (AGE) formation Fulltext Access 11 Pages 2009
Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases Fulltext Access 11 Pages 2009
Indene-based frameworks targeting the 5-HT6 serotonin receptor: Ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts Fulltext Access 11 Pages 2009
Hepatoprotective amide constituents from the fruit of Piper chaba: Structural requirements, mode of action, and new amides Fulltext Access 11 Pages 2009
Synthesis and evaluation of benzo[b]thiophene derivatives as inhibitors of alkaline phosphatases Fulltext Access 11 Pages 2009
Design, synthesis and evaluation of monovalent ligands for the asialoglycoprotein receptor (ASGP-R) Fulltext Access 11 Pages 2009
2,4-Diaminopyrimidines as histamine H4 receptor ligands—Scaffold optimization and pharmacological characterization Fulltext Access 11 Pages 2009
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: Investigating the hypothesis of shared structure–activity relationships Fulltext Access 11 Pages 2009
Sesquiterpene-like inhibitors of a 9-cis-epoxycarotenoid dioxygenase regulating abscisic acid biosynthesis in higher plants Fulltext Access 11 Pages 2009
8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands Fulltext Access 11 Pages 2009
Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators Fulltext Access 11 Pages 2009
Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues Fulltext Access 11 Pages 2009
Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, OH scavenging and anti-adhesive activities Fulltext Access 11 Pages 2009
Rapid identification of acetophenones in two Cynanchum species using liquid chromatography-electrospray ionization tandem mass spectrometry Fulltext Access 11 Pages 2009
Developing and optimizing a validated isocratic reversed-phase high-performance liquid chromatography separation of nimodipine and impurities in tablets using experimental design methodology Fulltext Access 11 Pages 2009
Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors Fulltext Access 11 Pages 2009
Penoxsulam—Structure–activity relationships of triazolopyrimidine sulfonamides Fulltext Access 11 Pages 2009
Synthesis, DNA intercalation and 3D QSAR analysis of cis-2,4,5-trisubstituted-1,3-dithiolanes as a novel class of antitumor agents Fulltext Access 11 Pages 2009
Free and bound state structures of 6-O-methyl homoerythromycins and epitope mapping of their interactions with ribosomes Fulltext Access 11 Pages 2009
Synthesis and evaluation of dihydroartemisinin and dihydroartemisitene acetal dimers showing anticancer and antiprotozoal activity Fulltext Access 11 Pages 2009
Synthesis, biological evaluation and quantitative structure-activities relationship of flavonoids as vasorelaxant agents Fulltext Access 11 Pages 2009
Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors Fulltext Access 11 Pages 2009
A TOPological Sub-structural Molecular Design (TOPS-MODE)-QSAR approach for modeling the antiproliferative activity against murine leukemia tumor cell line (L1210) Fulltext Access 11 Pages 2009
Design, synthesis and biological evaluation of novel stilbene-based antitumor agents Fulltext Access 11 Pages 2009
Modification of the furan ring of salvinorin A: Identification of a selective partial agonist at the kappa opioid receptor Fulltext Access 11 Pages 2009
Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-κB Fulltext Access 11 Pages 2009
Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists Fulltext Access 11 Pages 2009
Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: Effect on affinity and selectivity for dopamine D3 receptor Fulltext Access 11 Pages 2009
2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides Fulltext Access 11 Pages 2009
Synthesis and structure-activity relationships of N-(4-amino-2,6-diisopropylphenyl)-N'-(1,4-diarylpiperidine-4-yl)methylureas as anti-hyperlipidemic agents Fulltext Access 11 Pages 2009
Chemistry of renieramycins. Part 8: Synthesis and cytotoxicity evaluation of renieramycin M–jorunnamycin A analogues Fulltext Access 11 Pages 2009
Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases Fulltext Access 11 Pages 2009
Development of N-[11C]methylamino 4-hydroxy-2(1H)-quinolone derivatives as PET radioligands for the glycine-binding site of NMDA receptors Fulltext Access 11 Pages 2009
Abscinazole-F1, a conformationally restricted analogue of the plant growth retardant uniconazole and an inhibitor of ABA 8′-hydroxylase CYP707A with no growth-retardant effect Fulltext Access 11 Pages 2009
New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: Synthesis, biological evaluation, and mechanism of action studies Fulltext Access 11 Pages 2009
Design, Synthesis and Pharmacological Screening of Novel Antihypertensive Agents Using Hybrid Approach Fulltext Access 11 Pages 2009
Synthesis and biological activity of 1,4-dihydrobenzothiopyrano[4,3-c]pyrazole derivatives, novel pro-apoptotic mitochondrial targeted agents Fulltext Access 11 Pages 2009
Structure–activity relationship studies of 5-benzylaminoimidazo[1,2-c]pyrimidine-8-carboxamide derivatives as potent, highly selective ZAP-70 kinase inhibitors Fulltext Access 11 Pages 2009
QSAR and complex network study of the chiral HMGR inhibitor structural diversity Fulltext Access 11 Pages 2009
Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes Fulltext Access 11 Pages 2009
Discovery of novel dual functional agent as PPARγ agonist and 11β-HSD1 inhibitor for the treatment of diabetes Fulltext Access 11 Pages 2009
Novel aminopeptidase N inhibitors derived from antineoplaston AS2–5 (Part II) Fulltext Access 11 Pages 2009
Identification of potential cellular targets of aloisine A by affinity chromatography Fulltext Access 11 Pages 2009
Syntheses and biological evaluations of carbosilane dendrimers uniformly functionalized with sialyl α(2→3) lactose moieties as inhibitors for human influenza viruses Fulltext Access 11 Pages 2009
Synthesis and radiopharmacological investigation of 3-[4′-[18F]fluorobenzylidene]indolin-2-one as possible tyrosine kinase inhibitor Fulltext Access 11 Pages 2009
Synthesis of tetraglucosyl- and tetrapolyamine–tetrabenzoporphyrin conjugates for an application in PDT Fulltext Access 11 Pages 2009
Identification and determination of the major constituents in Traditional Chinese Medicinal formula Danggui-Shaoyao-San by HPLC–DAD–ESI-MS/MS Fulltext Access 11 Pages 2009
2D and 3D DOSY 1H NMR, a useful tool for analysis of complex mixtures: Application to herbal drugs or dietary supplements for erectile dysfunction Fulltext Access 11 Pages 2009
Simultaneous determination of propranolol and 4-hydroxy propranolol in human plasma by solid phase extraction and liquid chromatography/electrospray tandem mass spectrometry Fulltext Access 11 Pages 2009
Development of HPLC fingerprints for Mallotus species extracts and evaluation of the peaks responsible for their antioxidant activity Fulltext Access 11 Pages 2009
Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation Fulltext Access 11 Pages 2009
Structural–activity relationship study of highly-functionalized imidazolines as potent inhibitors of nuclear transcription factor-κB mediated IL-6 production Fulltext Access 11 Pages 2009
Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified d-phenylalanine residues Fulltext Access 11 Pages 2009
Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes Fulltext Access 11 Pages 2009
Structural optimization of a CXCR2-directed antagonist that indirectly inhibits γ-secretase and reduces Aβ Fulltext Access 11 Pages 2009
Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT6 agonists Fulltext Access 11 Pages 2009
Synthesis, antibacterial activities and molecular docking studies of peptide and Schiff bases as targeted antibiotics Fulltext Access 11 Pages 2009
Synthesis of novel purine nucleosides towards a selective inhibition of human butyrylcholinesterase Fulltext Access 11 Pages 2009
Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation and structure–activity relationships. Part 2 Fulltext Access 11 Pages 2009
Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries Fulltext Access 11 Pages 2009
Novel indoline-based acyl-CoA: cholesterol acyltransferase inhibitor: Effects of introducing a methanesulfonamide group on physicochemical properties and biological activities Fulltext Access 12 Pages 2009
The development and validation of a sensitive, dual-flow cell, SPR-based biosensor immunoassay for the detection, semi-quantitation, and characterization of antibodies to darbepoetin alfa and epoetin alfa in human serum Fulltext Access 12 Pages 2009
Fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1 Fulltext Access 12 Pages 2009
Evaluation of oligosaccharide methods for carbohydrate analysis in a fully human monoclonal antibody and comparison of the results to the monosaccharide composition determination by a novel calculation Fulltext Access 12 Pages 2009
Discovery of the butenyl-spinosyn insecticides: Novel macrolides from the new bacterial strain Saccharopolyspora pogona Fulltext Access 12 Pages 2009
Synthesis, cytotoxic activity, DNA topoisomerase-II inhibition, molecular modeling and structure–activity relationship of 9-anilinothiazolo[5,4-b]quinoline derivatives Fulltext Access 12 Pages 2009
Synthesis and evaluation of novel phenoxypropanolamine derivatives containing acetanilides as potent and selective β3-adrenergic receptor agonists Fulltext Access 12 Pages 2009
Preparation of two sets of 5,6,7-trioxygenated dihydroflavonol derivatives as free radical scavengers and neuronal cell protectors to oxidative damage Fulltext Access 12 Pages 2009
Volatile composition of Catharanthus roseus (L.) G. Don using solid-phase microextraction and gas chromatography/mass spectrometry Fulltext Access 12 Pages 2009
ω-Conotoxin GVIA mimetics based on an anthranilamide core: Effect of variation in ammonium side chain lengths and incorporation of fluorine Fulltext Access 12 Pages 2009
SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents Fulltext Access 12 Pages 2009
Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2MD) selectively eliminates bone calcium mobilization activity Fulltext Access 12 Pages 2009
Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones Fulltext Access 12 Pages 2009
7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: Synthesis and in vitro biological evaluation as potential antitumor agents Fulltext Access 12 Pages 2009
Novel orally active NPY Y5 receptor antagonists: Synthesis and structure–activity relationship of spiroindoline class compounds Fulltext Access 12 Pages 2009
Glucose-based spiro-heterocycles as potent inhibitors of glycogen phosphorylase Fulltext Access 12 Pages 2009
Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway Fulltext Access 12 Pages 2009
Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors Fulltext Access 12 Pages 2009
Synthesis of oxalamide and triazine derivatives as a novel class of hybrid 4-aminoquinoline with potent antiplasmodial activity Fulltext Access 12 Pages 2009
3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands Fulltext Access 12 Pages 2009
Synthesis and structural optimization of multiple H-bonding region of diarylalkyl (thio)amides as novel TRPV1 antagonists Fulltext Access 12 Pages 2009
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation Fulltext Access 12 Pages 2009
Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors Fulltext Access 12 Pages 2009