The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6â²-N-acetyltransferase and the role of 6â²-NH2 in antibacterial activity Fulltext Access 8 Pages 2007
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes Fulltext Access 8 Pages 2007
3-(3,4,5-Trimethoxyphenyl)-1-oxo-2-propene: A novel pharmacophore displaying potent multidrug resistance reversal and selective cytotoxicity Fulltext Access 8 Pages 2007
Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110α inhibitors Fulltext Access 8 Pages 2007
Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D4-selective ligand Fulltext Access 8 Pages 2007
Inclusion complexes of pyrimethamine in 2-hydroxypropyl-β-cyclodextrin: Characterization, phase solubility and molecular modelling Fulltext Access 8 Pages 2007
Synthesis and evaluation as MRI probe of the trifluoromethylated p-boronophenylalanine and its alcohol derivative Fulltext Access 8 Pages 2007
2(S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors Fulltext Access 8 Pages 2007
High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase Fulltext Access 8 Pages 2007
Synthesis and insecticidal activity of chromanone and chromone analogues of diacylhydrazines Fulltext Access 8 Pages 2007
Synthesis of 3-[4′-(p-chlorophenyl)-thiazol-2′-yl]-2-[(substituted azetidinone/thiazolidinone)-aminomethyl]-6-bromoquinazolin-4-ones as anti-inflammatory agent Fulltext Access 8 Pages 2007
On the cytotoxicity and status of oxidative stress of two novel synthesized tri-aza macrocyclic diamides as studied in the V79 cell lines Fulltext Access 8 Pages 2007
Quantitative structure–activity relationship of sesquiterpene lactones with cytotoxic activity Fulltext Access 8 Pages 2007
Short-chain 3-ketoceramides, strong apoptosis inducers against human leukemia HL-60 cells Fulltext Access 8 Pages 2007
The preparation and antioxidant activity of the sulfanilamide derivatives of chitosan and chitosan sulfates Fulltext Access 8 Pages 2007
3-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-6-substituted-3,6-diazabicyclo[3.1.1]heptanes as novel potent dopamine uptake inhibitors Fulltext Access 8 Pages 2007
Remarkable drug-release enhancement with an elimination-based AB3 self-immolative dendritic amplifier Fulltext Access 8 Pages 2007
Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease Fulltext Access 8 Pages 2007
Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit Fulltext Access 8 Pages 2007
A new class of nifuroxazide analogues: Synthesis of 5-nitrothiophene derivatives with antimicrobial activity against multidrug-resistant Staphylococcus aureus Fulltext Access 8 Pages 2007
Synthesis, structure, and structure-activity relationship analysis of enamines as potential antibacterials Fulltext Access 8 Pages 2007
Double mode of inhibition-inducing interactions of 1,4-naphthoquinone with urease: Arylation versus oxidation of enzyme thiols Fulltext Access 8 Pages 2007
Synthesis and biological evaluation of phosphino dipeptide isostere inhibitor of human β-secretase (BACE1) Fulltext Access 8 Pages 2007
Innovation and the WHO's essential medicines list: Giving credit where credit is due Fulltext Access 8 Pages 2007
Extract of Pelargonium sidoides (EPs® 7630) inhibits the interactions of group A-streptococci and host epithelia in vitro Fulltext Access 8 Pages 2007
Mass spectroscopic characterisation of oligomeric proanthocyanidins derived from an extract of Pelargonium sidoides roots (EPs® 7630) and pharmacological screening in CNS models Fulltext Access 8 Pages 2007
Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats Fulltext Access 8 Pages 2007
Piplartine, an amide alkaloid from Piper tuberculatum, presents anxiolytic and antidepressant effects in mice Fulltext Access 8 Pages 2007
Inhibitory activity of stilbenes on Alzheimer’s β-amyloid fibrils in vitro Fulltext Access 8 Pages 2007
Synthesis, characterization, and in vivo skeletal localization of a new 99mTc-based multidentate phosphonate chelate: 5-Amino-1,3-bis(ethylamine-(N,N dimethyl diphosphonic acid) acetamido) benzene Fulltext Access 8 Pages 2007
Antinociceptive and antiinflammatory activities and QSAR studies on 2-substituted-4,5-diphenyl-1H-imidazoles Fulltext Access 8 Pages 2007
Analgesic agents without gastric damage: Design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors Fulltext Access 8 Pages 2007
Fluoro-ketopyranosyl nucleosides: Synthesis and biological evaluation of 3-fluoro-2-keto-β-d-glucopyranosyl derivatives of N4-benzoyl cytosine Fulltext Access 8 Pages 2007
Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides Fulltext Access 8 Pages 2007
Synthesis of 1,3-diphenyl-2-propen-1-one derivatives and evaluation of their biological activities Fulltext Access 8 Pages 2007
Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs Fulltext Access 8 Pages 2007
Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa Fulltext Access 8 Pages 2007
Structure-activity relationships of pentacycloundecylamines at the N-methyl-d-aspartate receptor Fulltext Access 8 Pages 2007
Structure–activity relationships of 19-norvitamin D analogs having a fluoroethylidene group at the C-2 position Fulltext Access 8 Pages 2007
Design, synthesis, and in vivo evaluation of oxamniquine methacrylate and acrylamide prodrugs Fulltext Access 8 Pages 2007
The synthesis of amphipathic prodrugs of 1,2-diol drugs with saccharide conjugates by high regioselective enzymatic protocol Fulltext Access 8 Pages 2007
Synthesis and characterization of poly (amino ester) for slow biodegradable gene delivery vector Fulltext Access 8 Pages 2007
Synthesis, cytotoxicity, and DNA topoisomerase II inhibitory activity of benzofuroquinolinediones Fulltext Access 8 Pages 2007
Studies of inclusion complexes of natural and modified cyclodextrin with (+)catechin by NMR and molecular modeling Fulltext Access 8 Pages 2007
Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris Fulltext Access 8 Pages 2007
Design, synthesis, and biological evaluation of LNA nucleosides as adenosine A3 receptor ligands Fulltext Access 8 Pages 2007
Synthesis and in vitro evaluation of leishmanicidal and trypanocidal activities of N-quinolin-8-yl-arylsulfonamides Fulltext Access 8 Pages 2007
An RNA aptamer that recognizes a specific conformation of the protein calsenilin Fulltext Access 8 Pages 2007
Novel chalcones as probes for in vivo imaging of β-amyloid plaques in Alzheimer’s brains Fulltext Access 8 Pages 2007
The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine Fulltext Access 8 Pages 2007
Cytotoxic dibromotyrosine-derived metabolites from the sponge Aplysina gerardogreeni Fulltext Access 8 Pages 2007
Impaired mutagenic activities of MPDP+ (1-methyl-4-phenyl-2,3-dihydropyridinium) and MPP+ (1-methyl-4-phenylpyridinium) due to their interactions with methylxanthines Fulltext Access 8 Pages 2007
Molecular design, chemical synthesis, and biological evaluation of ‘4-1’ pentacyclic aryl/heteroaryl-imidazonaphthalimides Fulltext Access 8 Pages 2007
Synthesis and evaluation of human T cell stimulating activity of an α-sulfatide analogue Fulltext Access 8 Pages 2007
Paclitaxel binding to the fatty acid-induced conformation of human serum albumin—Automated docking studies Fulltext Access 8 Pages 2007
The synthesis of 18β-glycyrrhetinic acid derivatives which have increased antiproliferative and apoptotic effects in leukemia cells Fulltext Access 8 Pages 2007
Inhibition of S. aureus α-hemolysin and B. anthracis lethal toxin by β-cyclodextrin derivatives Fulltext Access 8 Pages 2007
Synthesis and evaluation of water-soluble docetaxel prodrugs-docetaxel esters of malic acid Fulltext Access 8 Pages 2007
Modification of eukaryotic initiation factor 5A from Plasmodium vivax by a truncated deoxyhypusine synthase from Plasmodium falciparum: An enzyme with dual enzymatic properties Fulltext Access 8 Pages 2007
Isosteric probes provide structural requirements essential for detoxification of the phytoalexin brassinin by the fungal pathogen Leptosphaeria maculans Fulltext Access 8 Pages 2007
O2-Acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO–NSAIDs): Synthesis, nitric oxide release, and biological evaluation studies Fulltext Access 8 Pages 2007
Synthesis of a novel ‘smart’ bifunctional chelating agent 1-(2-[β,d-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH2) and its Gd(III) complex Fulltext Access 8 Pages 2007
Synthesis and inhibitory activity of new benzimidazole derivatives against Burkitt’s lymphoma promotion Fulltext Access 8 Pages 2007
Synthesis of diverse analogues of Oenostacin and their antibacterial activities Fulltext Access 8 Pages 2007
Scaffold hopping, synthesis and structure–activity relationships of 5,6-diaryl-pyrazine-2-amide derivatives: A novel series of CB1 receptor antagonists Fulltext Access 8 Pages 2007
Synthesis of pH-sensitive amphotericin B–poly(ethylene glycol) conjugates and study of their controlled release in vitro Fulltext Access 8 Pages 2007
Substituted 6-amino-4H-[1,2]dithiolo[4,3-b]pyrrol-5-ones: Synthesis, structure–activity relationships, and cytotoxic activity on selected human cancer cell lines Fulltext Access 8 Pages 2007
Isolation of new phenylacetylingol derivatives that reactivate HIV-1 latency and a novel spirotriterpenoid from Euphorbia officinarum latex Fulltext Access 8 Pages 2007
Expeditious and convenient synthesis of pregnanes and its glycosides as potential anti-dyslipidemic and anti-oxidant agents Fulltext Access 8 Pages 2007
Construction of polyamine-modified uridine and adenosine derivatives—evaluation of DNA binding capacity and cytotoxicity in vitro Fulltext Access 8 Pages 2007
Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: Derivatives of irbesartan key intermediate Fulltext Access 8 Pages 2007
Carbonic anhydrase inhibitors: Cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides Fulltext Access 8 Pages 2007
Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition Fulltext Access 8 Pages 2007
Synthesis, characterization and biological activity of complexes of lanthanum(III) with 2-(1′-phenyl- 2′-carboxyl-3′-aza-n-butyl)-1,10-phenanthroline and 2-(1′-p-phenol-2′-carboxyl-3′-aza-n-butyl)-1,10-phenanthroline Fulltext Access 8 Pages 2007
Synthesis of cryptolepine analogues as potential bioreducible anticancer agents Fulltext Access 8 Pages 2007
The design, synthesis, and biological evaluation of novel substituted purines as HIV-1 Tat–TAR inhibitors Fulltext Access 8 Pages 2007
Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus Fulltext Access 8 Pages 2007
Design, synthesis, and biological evaluation of novel iso-d-2â²,3â²-dideoxy-3â²-fluorothianucleoside derivatives Fulltext Access 8 Pages 2007
Synthesis of a non-cationic, water-soluble perylenetetracarboxylic diimide and its interactions with G-quadruplex-forming DNA Fulltext Access 8 Pages 2007
Structural requirement of chalcones for the inhibitory activity of interleukin-5 Fulltext Access 8 Pages 2007
Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2′O)-methyltransferase Fulltext Access 8 Pages 2007
Synthesis of some tropane derivatives of anticipated activity on the reuptake of norepinephrine and/or serotonin Fulltext Access 8 Pages 2007
In vivo growth inhibitory and anti-angiogenic effects of synthetic novel dienone cyclopropoxy curcumin analogs on mouse Ehrlich ascites tumor Fulltext Access 8 Pages 2007
Elucidation of the RNA target of linezolid by using a linezolid–neomycin B heteroconjugate and genomic SELEX Fulltext Access 8 Pages 2007
Synthesis and in vitro evaluation of 5-arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte cultures Fulltext Access 8 Pages 2007