The role of degradant profiling in active pharmaceutical ingredients and drug products Fulltext Access 9 Pages 2007
Tetronic micellization, gelation and drug solubilization: Influence of pH and ionic strength Fulltext Access 9 Pages 2007
Correlation between digestion of the lipid phase of smedds and release of the anti-HIV drug UC 781 and the anti-mycotic drug enilconazole from smedds Fulltext Access 9 Pages 2007
Solid-state characterization and dissolution profiles of the inclusion complexes of omeprazole with native and chemically modified β-cyclodextrin Fulltext Access 9 Pages 2007
In-vitro/in-vivo correlation of pulsatile drug release from press-coated tablet formulations: A pharmacoscintigraphic study in the beagle dog Fulltext Access 9 Pages 2007
Stress relaxation test for the characterization of the viscoelasticity of pellets Fulltext Access 9 Pages 2007
Release of naltrexone on buccal mucosa: Permeation studies, histological aspects and matrix system design Fulltext Access 9 Pages 2007
Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: Can the simple nutritional supplements be used as first line therapeutic agents for prophylaxis/therapy? Fulltext Access 9 Pages 2007
Re-dispersible cationic solid lipid nanoparticles (SLNs) freeze-dried without cryoprotectors: Characterization and ability to bind the pEGFP-plasmid Fulltext Access 9 Pages 2007
Pharmaceutical impurities: Regulatory perspective for Abbreviated New Drug Applications Fulltext Access 9 Pages 2007
Preparation and antitumor characteristics of PLA/(PEG-PPG-PEG) nanoparticles loaded with camptothecin Fulltext Access 9 Pages 2007
Drug delivery to peroxisomes: Employing unique trafficking mechanisms to target protein therapeutics Fulltext Access 9 Pages 2007
Considerations for the sensible use of rodent models of inflammatory disease in predicting efficacy of new biological therapeutics in the clinic Fulltext Access 9 Pages 2007
Non-steroidal glucocorticoid agonists—The discovery of aryl pyrazoles as A-ring mimetics Fulltext Access 9 Pages 2007
The design and synthesis of N-1-alkylated-5-aminoaryalkylsubstituted-6-methyluracils as potential non-nucleoside HIV-1 RT inhibitors Fulltext Access 9 Pages 2007
Novel cationic and neutral glycocholic acid and polyamine conjugates able to inhibit transporters involved in hepatic and intestinal bile acid uptake Fulltext Access 9 Pages 2007
Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids Fulltext Access 9 Pages 2007
Synthesis and biological evaluation of dihydrofuran-fused perhydrophenanthrenes as a new anti-influenza agent having novel structural characteristic Fulltext Access 9 Pages 2007
Chitosan microspheres enhance the immunogenicity of an Ag85B-based fusion protein containing multiple T-cell epitopes of Mycobacterium tuberculosis Fulltext Access 9 Pages 2007
Development of hollow/porous calcium pectinate beads for floating-pulsatile drug delivery Fulltext Access 9 Pages 2007
Conformational analysis of protein secondary structure during spray-drying of antibody/mannitol formulations Fulltext Access 9 Pages 2007
Topical non-invasive gene delivery using gemini nanoparticles in interferon-γ-deficient mice Fulltext Access 9 Pages 2007
pH-responsive polymeric micelles of poly(ethylene glycol)-b-poly(alkyl(meth)acrylate-co-methacrylic acid): Influence of the copolymer composition on self-assembling properties and release of candesartan cilexetil Fulltext Access 9 Pages 2007
Effect of preparation conditions on the nutrient release properties of alginate–whey protein granular microspheres Fulltext Access 9 Pages 2007
Solid molecular dispersions of poorly water-soluble drugs in poly(2-hydroxyethyl methacrylate) hydrogels Fulltext Access 9 Pages 2007
In vivo evaluation of a new polymer-lipid hybrid nanoparticle (PLN) formulation of doxorubicin in a murine solid tumor model Fulltext Access 9 Pages 2007
Influence of sample characteristics on quantification of carbamazepine hydrate formation by X-ray powder diffraction and Raman spectroscopy Fulltext Access 9 Pages 2007
Assessment of physical and antioxidant activity stability, in vitro release and in vivo efficacy of formulations added with superoxide dismutase alone or in association with α-tocopherol Fulltext Access 9 Pages 2007
Preparation and characterization of simvastatin/hydroxypropyl-β-cyclodextrin inclusion complex using supercritical antisolvent (SAS) process Fulltext Access 9 Pages 2007
Loading and delivery of sertraline using inorganic micro and mesoporous materials Fulltext Access 9 Pages 2007
Enhanced in vitro permeation of furosemide loaded into thermally carbonized mesoporous silicon (TCPSi) microparticles Fulltext Access 9 Pages 2007
Novel T-type calcium channel blockers: Dioxoquinazoline carboxamide derivatives Fulltext Access 9 Pages 2007
Functional characterization of cell lines for high-throughput screening of human neuromedin U receptor subtype 2 specific agonists using a luciferase reporter gene assay Fulltext Access 9 Pages 2007
The determination of the mechanical strength of tablets of different shapes Fulltext Access 9 Pages 2007
Alginate-based pellets prepared by extrusion/spheronization: A preliminary study on the effect of additive in granulating liquid Fulltext Access 9 Pages 2007
Swelling and erosion of pectin matrix tablets and their impact on drug release behavior Fulltext Access 9 Pages 2007
Colonic delivery of compression coated nisin tablets using pectin/HPMC polymer mixture Fulltext Access 9 Pages 2007
Modulating drug release and matrix erosion of alginate matrix capsules by microenvironmental interaction with calcium ion Fulltext Access 9 Pages 2007
Effect of HLB of additives on the properties and drug release from the glyceryl monooleate matrices Fulltext Access 9 Pages 2007
Mucoadhesive properties of various pectins on gastrointestinal mucosa: An in vitro evaluation using texture analyzer Fulltext Access 9 Pages 2007
A study of the formulation design of acoustically active lipospheres as carriers for drug delivery Fulltext Access 9 Pages 2007
Identification and quantification of metabolites common to 17α-methyltestosterone and mestanolone in horse urine Fulltext Access 9 Pages 2007
Naphthoindole-based analogues of tryptophan and tryptamine: Synthesis and cytotoxic properties Fulltext Access 9 Pages 2007
Synthesis of neutral and cationic tripyridylporphyrin-d-galactose conjugates and the photoinactivation of HSV-1 Fulltext Access 9 Pages 2007
Structure–activity relationship of chalcones and related derivatives as ligands for detecting of β-amyloid plaques in the brain Fulltext Access 9 Pages 2007
CP5484, a novel quaternary carbapenem with potent anti-MRSA activity and reduced toxicity Fulltext Access 9 Pages 2007
Thermodynamic properties of flufenamic and niflumic acids—Specific and non-specific interactions in solution and in crystal lattices, mechanism of solvation, partitioning and distribution Fulltext Access 9 Pages 2007
Determination of rifalazil in dog plasma by liquid-liquid extraction and LC-MS/MS: Quality assessment by incurred sample analysis Fulltext Access 9 Pages 2007
Compatibility of the antitumoral β-lapachone with different solid dosage forms excipients Fulltext Access 9 Pages 2007
Enantioselective liquid chromatography–mass spectrometry assay for the determination of ifosfamide and identification of the N-dechloroethylated metabolites of ifosfamide in human plasma Fulltext Access 9 Pages 2007
Development of LC/MS/MS assay for the determination of 5-ethyl-2-{5-[4-(2-hydroxyethyl)piperazine-1-sulfonyl]-2-propoxyphenyl}-7-propyl-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one (SK3530) in human plasma: application to a clinical pharmacokinetic study Fulltext Access 9 Pages 2007
Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors Fulltext Access 9 Pages 2007
Chromatographic fingerprint analysis of Cephalotaxus sinensis from various sources by high-performance liquid chromatography–diodearray detection–electrospray ionization-tandem mass spectrometry Fulltext Access 9 Pages 2007
Identification of an unknown extraneous contaminant in pharmaceutical product analysis Fulltext Access 9 Pages 2007
Development and validation of HPLC-DAD methods for the analysis of two novel iron chelators with potent anti-cancer activity Fulltext Access 9 Pages 2007
Does the preferred orientation of crystallites in tablets affect the intrinsic dissolution? Fulltext Access 9 Pages 2007
Complete resolution of the microscopic protonation equilibria of N-methyl-d-aspartic acid and related compounds Fulltext Access 9 Pages 2007
Analysis of multiple constituents in a Chinese herbal preparation Shuang-Huang-Lian oral liquid by HPLC-DAD-ESI-MSn Fulltext Access 9 Pages 2007
Impurity profile tracking for active pharmaceutical ingredients: Case reports Fulltext Access 9 Pages 2007
Chromatography–mass spectrometry methods for the quantitation of statins in biological samples Fulltext Access 9 Pages 2007
Development and validation of urinary nucleosides and creatinine assay by capillary electrophoresis with solid phase extraction Fulltext Access 9 Pages 2007
Fast gas chromatography and negative-ion chemical ionization tandem mass spectrometry for forensic analysis of cannabinoids in whole blood Fulltext Access 9 Pages 2007
Characterized mechanism of α-mangostin-induced cell death: Caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells Fulltext Access 9 Pages 2007
Fujita-Ban QSAR analysis and CoMFA study of quinoline antagonists of immunostimulatory CpG-oligodeoxynucleotides Fulltext Access 9 Pages 2007
Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series Fulltext Access 9 Pages 2007
A novel QSAR model for prediction of apoptosis-inducing activity of 4-aryl-4-H-chromenes based on support vector machine Fulltext Access 9 Pages 2007
Synthesis and antibacterial activity of pyranmycin derivatives with N-1 and O-6 modifications Fulltext Access 9 Pages 2007
Activity of 7-methyljuglone derivatives against Mycobacterium tuberculosis and as subversive substrates for mycothiol disulfide reductase Fulltext Access 9 Pages 2007
Identification of C10 biotinylated camptothecin (CPT-10-B) binding peptides using T7 phage display screen on a QCM device Fulltext Access 9 Pages 2007
1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems Fulltext Access 9 Pages 2007
Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening Fulltext Access 9 Pages 2007
Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker—Preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase Fulltext Access 9 Pages 2007
Synthetic control of interchromophoric interaction in cationic bis-porphyrins toward efficient DNA photocleavage and singlet oxygen production in aqueous solution Fulltext Access 9 Pages 2007
Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: Insights from molecular modeling studies Fulltext Access 9 Pages 2007
Development and validation of a liquid chromatographic method for the determination of branched-chain amino acids in new dosage forms Fulltext Access 9 Pages 2007
9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA Fulltext Access 9 Pages 2007
Exomethylene pyranonucleosides: Efficient synthesis and biological evaluation of 1-(2,3,4-trideoxy-2-methylene-β-d-glycero-hex-3-enopyranosyl)thymine Fulltext Access 9 Pages 2007
Structure-based design of α-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2 Fulltext Access 9 Pages 2007
Utility of 6-amino-2-thiouracil as a precursor for the synthesis of bioactive pyrimidine derivatives Fulltext Access 9 Pages 2007
LNA nucleotides improve cleavage efficiency of singular and binary hammerhead ribozymes Fulltext Access 9 Pages 2007
Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation Fulltext Access 9 Pages 2007
Dihydroxyxanthones prenylated derivatives: Synthesis, structure elucidation, and growth inhibitory activity on human tumor cell lines with improvement of selectivity for MCF-7 Fulltext Access 9 Pages 2007
Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents Fulltext Access 9 Pages 2007
Identification and characterization of novel sodium/potassium-ATPase inhibitors by virtual screening of a compound database Fulltext Access 9 Pages 2007
Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents Fulltext Access 9 Pages 2007