Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents Fulltext Access 9 Pages 2007
Synthesis and in vitro antitumoral activity of new 3,5-dicyanopyridine derivatives Fulltext Access 9 Pages 2007
Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: A new class of antiviral acyclic nucleoside phosphonates Fulltext Access 9 Pages 2007
Synthesis of furopyrazole analogs of 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) as novel anti-leukemia agents Fulltext Access 9 Pages 2007
Discovery of a new insecticide lead by optimizing a target-diverse scaffold: Tetrazolinone derivatives Fulltext Access 9 Pages 2007
Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: Design, synthesis, and pharmacological characterization Fulltext Access 9 Pages 2007
Synthesis and cytotoxic evaluation of C-9 oxidized podophyllotoxin derivatives Fulltext Access 9 Pages 2007
Lactotriaose-containing carbosilane dendrimers: Syntheses and lectin-binding activities Fulltext Access 9 Pages 2007
The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4 Fulltext Access 9 Pages 2007
Synthesis of carbamate derivatives of iejimalides. Retention of normal antiproliferative activity and localization of binding in cancer cells Fulltext Access 9 Pages 2007
First synthesis of 7α- and 7β-amino-DHEA, dehydroepiandrosterone (DHEA) analogues and preliminary evaluation of their cytotoxicity on Leydig cells and TM4 Sertoli cells Fulltext Access 9 Pages 2007
Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore Fulltext Access 9 Pages 2007
Methotrexate γ-hydroxamate derivatives as potential dual target antitumor drugs Fulltext Access 9 Pages 2007
Conformational analysis of endomorphin-2 analogs with phenylalanine mimics by NMR and molecular modeling Fulltext Access 9 Pages 2007
First pharmacophore-based identification of androgen receptor down-regulating agents: Discovery of potent anti-prostate cancer agents Fulltext Access 9 Pages 2007
Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines Fulltext Access 9 Pages 2007
Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor Fulltext Access 9 Pages 2007
Synthesis and pharmacochemical evaluation of novel aryl-acetic acid inhibitors of lipoxygenase, antioxidants, and anti-inflammatory agents Fulltext Access 9 Pages 2007
Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug Fulltext Access 9 Pages 2007
SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa Fulltext Access 9 Pages 2007
In vitro assessment of cytochrome P450 inhibition: Strategies for increasing LC/MSâbased assay throughput using a oneâpoint IC50 method and multiplexing highâperformance liquid chromatography Fulltext Access 9 Pages 2007
Oiling out or molten hydrate-liquid-liquid phase separation in the system vanillin-water Fulltext Access 9 Pages 2007
Impact of critical process and formulation parameters affecting inâprocess stability of lactate dehydrogenase during the secondary drying stage of lyophilization: A mini freeze dryer study Fulltext Access 9 Pages 2007
On the Calculation of the Concentration Dependence of Drug Binding to Plasma Proteins with Multiple Binding Sites of Different Affinities: Determination of the Possible Variation of the Unbound Drug Fraction and Calculation of the Number of Binding Sites Fulltext Access 9 Pages 2007
Decreased Drug Penetration in Inflamed Tissue Related to Changed Mucosal Metabolism in Experimental Colitis Fulltext Access 9 Pages 2007
Controlled Release of Chlorhexidine Diacetate from a Porous Methacrylate System: Supercritical Fluid Assisted Foaming and Impregnation Fulltext Access 9 Pages 2007
Quantitative structure–activity relationship (QSAR) of tacrine derivatives against acetylcholinesterase (AChE) activity using variable selections Fulltext Access 9 Pages 2007
Structure–activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors Fulltext Access 9 Pages 2007
Synthesis and structure–activity relationships of novel pyrimido[1,2-b]indazoles as potential anticancer agents against A-549 cell lines Fulltext Access 9 Pages 2007
RETRACTED: A computational docking study for prediction of binding mode of diospyrin and derivatives: Inhibitors of human and leishmanial DNA topoisomerase-I Fulltext Access 9 Pages 2007
Substitution at the 8-position of 3″-deoxy-cyclic ADP-carbocyclic-ribose, a highly potent Ca2+-mobilizing agent, provides partial agonists1 Fulltext Access 9 Pages 2007
Macrocyclic ureas as potent and selective Chk1 inhibitors: An improved synthesis, kinome profiling, structure–activity relationships, and preliminary pharmacokinetics Fulltext Access 9 Pages 2007
Identification of a series of tetrahydroisoquinoline derivatives as potential therapeutic agents for breast cancer Fulltext Access 9 Pages 2007
Prediction of binding affinities to β1 isoform of human thyroid hormone receptor by genetic algorithm and projection pursuit regression Fulltext Access 9 Pages 2007
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. Fulltext Access 9 Pages 2007
α-Biphenylsulfonylamino 2-methylpropyl phosphonates: Enantioselective synthesis and selective inhibition of MMPs Fulltext Access 9 Pages 2007
Synthesis, in vitro and in silico evaluation of l-tyrosine containing PPARα/γ dual agonists Fulltext Access 9 Pages 2007
Inhibition of horseradish peroxidase catalytic activity by new 3-phenylcoumarin derivatives: Synthesis and structure–activity relationships Fulltext Access 9 Pages 2007
High affinity Grb2-SH3 domain ligand incorporating Cβ-substituted prolines in a Sos-derived decapeptide Fulltext Access 9 Pages 2007
N-Phenyl-N′-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: Role of ω-hydroxyl group in the covalent binding to β-tubulin Fulltext Access 9 Pages 2007
Evaluation of [11C]hemicholinium-15 and [18F]hemicholinium-15 as new potential PET tracers for the high-affinity choline uptake system in the heart Fulltext Access 9 Pages 2007
Investigating biological activity spectrum for novel quinoline analogues Fulltext Access 9 Pages 2007
Quantitative determination of disaccharide content in digested unfragmented heparin and low molecular weight heparin by direct-infusion electrospray mass spectrometry Fulltext Access 9 Pages 2007
Design, synthesis and biological evaluation of novel lipoamino acid-based glycolipids for oral drug delivery Fulltext Access 9 Pages 2007
Synthesis and evaluation of chloromethyl sulfoxides as a new class of selective irreversible cysteine protease inhibitors Fulltext Access 9 Pages 2007
Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries Fulltext Access 9 Pages 2007
A sensitive liquid chromatography and mass spectrometry method for the determination of posaconazole in human plasma Fulltext Access 9 Pages 2007
Development of a sensitive size exclusion HPLC method with fluorescence detection for the quantitation of recombinant human erythropoietin (r-HuEPO) aggregates Fulltext Access 9 Pages 2007
Combinative method using HPLC quantitative and qualitative analyses for quality consistency assessment of a herbal medicinal preparation Fulltext Access 9 Pages 2007
Degradation of vitamin D3 in a stressed formulation: The identification of esters of vitamin D3 formed by a transesterification with triglycerides Fulltext Access 9 Pages 2007
An evaluation of four commercial HPLC chiral detectors: A comparison of three polarimeters and a circular dichroism detector Fulltext Access 9 Pages 2007
Characterization of a potential medium for ‘biorelevant’ in vitro release testing of a naltrexone implant, employing a validated stability-indicating HPLC method Fulltext Access 9 Pages 2007
New perspectives in bio-analytical techniques for preclinical characterization of a drug candidate: UPLC-MS/MS in in vitro metabolism and pharmacokinetic studies Fulltext Access 9 Pages 2007
Liquid-liquid extraction of strongly protein bound BMS-299897 from human plasma and cerebrospinal fluid, followed by high-performance liquid chromatography/tandem mass spectrometry Fulltext Access 9 Pages 2007
QSAR studies on the activation of the human carbonic anhydrase cytosolic isoforms I and II and secretory isozyme VI with amino acids and amines Fulltext Access 9 Pages 2007
Determination of catecholamines by flow-injection analysis and high-performance liquid chromatography with chemiluminescence detection Fulltext Access 9 Pages 2007
Understanding the degradation pathway of a poorly water-soluble drug formulated in PEG-400 Fulltext Access 9 Pages 2007
Validation and implementation of drug-dependent antibody assays in clinical trials for safety monitoring of patients dosed with roxifiban, an orally bioavailable glycoprotein IIb/IIIa antagonist Fulltext Access 9 Pages 2007
Effect of PA-MSHA vaccine on plasma phospholipids metabolic profiling and the ratio of Th2/Th1 cells within immune organ of mouse IgA nephropathy Fulltext Access 9 Pages 2007
Evaluation of supercritical fluid technology as preparative technique of benzocaine–cyclodextrin complexes—Comparison with conventional methods Fulltext Access 9 Pages 2007
Characterization of hydroxypropylmethylcellulose films using microwave non-destructive testing technique Fulltext Access 9 Pages 2007
Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Scutellaria baicalensis Georgi using capillary electrophoresis Fulltext Access 9 Pages 2007
C18 columns for the simultaneous determination of oxytetracycline and its related substances by reversed-phase high performance liquid chromatography and UV detection Fulltext Access 9 Pages 2007
Nateglinide quantification in rabbit plasma by HPLC: Optimization and application to pharmacokinetic study Fulltext Access 9 Pages 2007
The effect of analyte acidity on signal suppression and the implications to peak purity determinations using atmospheric pressure ionization mass spectrometry Fulltext Access 9 Pages 2007
Synthesis and glycogen phosphorylase inhibitor activity of 2,3-dihydrobenzo[1,4]dioxin derivatives Fulltext Access 9 Pages 2007
Structure–activity based study of the Smac-binding pocket within the BIR3 domain of XIAP Fulltext Access 9 Pages 2007
Hybrid molecules of estrone: New compounds with potential antibacterial, antifungal, and antiproliferative activities Fulltext Access 9 Pages 2007
1-(5-Carboxy- and 5-carbamoylindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2α: Bioisosteric replacement of the carboxylic acid and carboxamide moiety Fulltext Access 9 Pages 2007
Structure based de novo design of novel glycogen synthase kinase 3 inhibitors Fulltext Access 9 Pages 2007
Application of descriptors based on Lipinski's rules in the QSPR study of aqueous solubilities Fulltext Access 9 Pages 2007
Oxidation of C4-hydroxyphenyl 1,4-dihydropyridines in dimethylsulfoxide and its reactivity towards alkylperoxyl radicals in aqueous medium Fulltext Access 9 Pages 2007
Assessing potency of c-Jun N-terminal kinase 3 (JNK3) inhibitors using 2D molecular descriptors and binary QSAR methodology Fulltext Access 9 Pages 2007
Synthesis of andrographolide derivatives: A new family of α-glucosidase inhibitors Fulltext Access 9 Pages 2007
Studies of interactions between platinum(II) complexes and some biologically relevant molecules Fulltext Access 9 Pages 2007
Evaluation of the content and stability of the constituents of mother tinctures and tinctures: The case of Crataegus oxyacantha L. and Hieracium pilosella L. Fulltext Access 9 Pages 2007
Synthesis and antifungal activities of 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-thiadiazole and 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-oxadiazole derivatives Fulltext Access 9 Pages 2007
Fmoc-protected iminosugar modified asparagine derivatives as building blocks for glycomimetics-containing peptides Fulltext Access 9 Pages 2007
7-Substituted-melatonin and 7-substituted-1-methylmelatonin analogues: Effect of substituents on potency and binding affinity Fulltext Access 9 Pages 2007
Novel acyclic enediynes inhibit Cyclin A and Cdc25C expression and induce apoptosis phenomenon to show potent antitumor proliferation Fulltext Access 9 Pages 2007
Synthesis and radiopharmacological characterization of 2β-carbo-2â²-[18F]fluoroethoxy-3β-(4-bromo-phenyl)tropane ([18F]MCL-322) as a PET radiotracer for imaging the dopamine transporter (DAT) Fulltext Access 9 Pages 2007
2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship Fulltext Access 9 Pages 2007
Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease Fulltext Access 9 Pages 2007
5-(3-Cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile: A novel, highly potent, selective, and orally active non-steroidal progesterone receptor agonist Fulltext Access 9 Pages 2007