Synthesis of analogues of a flexible thiopyrylium photosensitizer for purging blood-borne pathogens and binding mode and affinity studies of their complexes with DNA Fulltext Access 13 Pages 2007
5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases Fulltext Access 13 Pages 2007
QSAR studies and pharmacophore identification for arylsubstituted cycloalkenecarboxylic acid methyl esters with affinity for the human dopamine transporter Fulltext Access 13 Pages 2007
Structure–activity studies on diphenylpyrazine derivatives: A novel class of prostacyclin receptor agonists Fulltext Access 13 Pages 2007
Ethanol enhanced in vivo gene delivery with non-ionic polymeric micelles inhalation Fulltext Access 13 Pages 2007
Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors Fulltext Access 13 Pages 2007
Solid-phase synthesis of a combinatorial library of dihydroceramide analogues and its activity in human alveolar epithelial cells Fulltext Access 13 Pages 2007
The effect of 5-substitution in the pyrimidine ring of dUMP on the interaction with thymidylate synthase: Molecular modeling and QSAR Fulltext Access 13 Pages 2007
Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors Fulltext Access 13 Pages 2007
Direct diazo-transfer reaction on β-lactam: Synthesis and preliminary biological activities of 6-triazolylpenicillanic acids Fulltext Access 13 Pages 2007
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds Fulltext Access 13 Pages 2007
New antitumoral acetogenin ‘Guanacone type’ derivatives: Isolation and bioactivity. Molecular dynamics simulation of diacetyl-guanacone Fulltext Access 13 Pages 2007
Development of a spray congealing process for the preparation of insulin-loaded lipid microparticles and characterization thereof Fulltext Access 13 Pages 2007
Novel 9a-carbamoyl- and 9a-thiocarbamoyl-3-decladinosyl-6-hydroxy and 6-methoxy derivatives of 15-membered macrolides Fulltext Access 13 Pages 2007
The structure–activity relationship of the series of non-peptide small antagonists for p56lck SH2 domain Fulltext Access 13 Pages 2007
Identification of antitumour activity of novel derivatives of 8-aryl-2,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazine-3,4-dione and 8-aryl-4-imino-2,3,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazin-3(6H)-one Fulltext Access 13 Pages 2007
Novel class of arylpiperazines containing N-acylated amino acids: Their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation Fulltext Access 13 Pages 2007
Synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione library: Effect of C2-aryl substitution on cytotoxicity and non-covalent DNA binding Fulltext Access 13 Pages 2007
Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents Fulltext Access 13 Pages 2007
C6-(N,N-butyl-methyl-heptanamide) derivatives of estrone and estradiol as inhibitors of type 1 17β-hydroxysteroid dehydrogenase: Chemical synthesis and biological evaluation Fulltext Access 13 Pages 2007
Further modification on phenyl acetic acid based quinolines as liver X receptor modulators Fulltext Access 13 Pages 2007
Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors Fulltext Access 13 Pages 2007
Synthesis and antitumor evaluation of a novel series of triaminotriazine derivatives Fulltext Access 13 Pages 2007
A liquid chromatography/mass spectrometric method for simultaneous analysis of arachidonic acid and its endogenous eicosanoid metabolites prostaglandins, dihydroxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and epoxyeicosatrienoic acids in rat br Fulltext Access 13 Pages 2007
Chemical and biological effects of substitution of the 2-position of ring-expanded (‘fat’) nucleosides containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system: The role of electronic and steric factors on glycosidic bond stability and anti-HCV a Fulltext Access 13 Pages 2007
Synthesis and structure–activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids Fulltext Access 13 Pages 2007
The influence of the long chain fatty acid on the antagonistic activities of Rhizobium sin-1 lipid A Fulltext Access 13 Pages 2007
Synthesis, structural characterization, and in vitro antitumor activity of novel N-(6-chloro-1,1-dioxo-1,4,2-benzodithiazin-3-yl)arylsulfonamides Fulltext Access 13 Pages 2007
Novel TOPP descriptors in 3D-QSAR analysis of apoptosis inducing 4-aryl-4H-chromenes: Comparison versus other 2D- and 3D-descriptors Fulltext Access 13 Pages 2007
Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication Fulltext Access 13 Pages 2007
Synthesis of dl-standishinal and its related compounds for the studies on structure–activity relationship of inhibitory activity against aromatase Fulltext Access 13 Pages 2007
An overview of recent applications of inductively coupled plasma-mass spectrometry (ICP-MS) in determination of inorganic impurities in drugs and pharmaceuticals Fulltext Access 13 Pages 2007
HPLC–NMR with severe column overloading: Fast-track metabolite identification in urine and bile samples from rat and dog treated with [14C]-ZD6126 Fulltext Access 13 Pages 2007
Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors Fulltext Access 13 Pages 2007
Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC–MS/MS analysis Fulltext Access 13 Pages 2007
QSAR modeling of matrix metalloproteinase inhibition by N-hydroxy-α-phenylsulfonylacetamide derivatives Fulltext Access 13 Pages 2007
4-Amino-5-vinyl-3(2H)-pyridazinones and analogues as potent antinociceptive agents: Synthesis, SARs, and preliminary studies on the mechanism of action Fulltext Access 13 Pages 2007
The thermodynamic dissociation constants of four non-steroidal anti-inflammatory drugs by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration data Fulltext Access 13 Pages 2007
Probing Pseudopolymorphic Transitions in Pharmaceutical Solids using Raman Spectroscopy: Hydration and Dehydration of Theophylline Fulltext Access 14 Pages 2007
Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand Fulltext Access 14 Pages 2007
Linker-modified triamine-linked acridine dimers: Synthesis and cytotoxicity properties in vitro and in vivo Fulltext Access 14 Pages 2007
Mechanistic Study of the Effect of Roller Compaction and Lubricant on Tablet Mechanical Strength Fulltext Access 14 Pages 2007
DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods Fulltext Access 14 Pages 2007
Novel screening assay for antioxidant protection against peroxyl radicalâinduced loss of protein function Fulltext Access 14 Pages 2007
Recent advances in high-throughput quantitative bioanalysis by LC–MS/MS Fulltext Access 14 Pages 2007
The Effect of Annealing on the Stability of Amorphous Solids: Chemical Stability of Freeze-Dried Moxalactam Fulltext Access 14 Pages 2007
Lipid Formulation Strategies for Enhancing Intestinal Transport and Absorption of P-Glycoprotein (P-gp) Substrate Drugs: In vitro/In vivo Case Studies Fulltext Access 14 Pages 2007
Demonstration of a Shear-Based Solid-State Phase Transformation in a Small Molecular organic System: Chlorpropamide Fulltext Access 14 Pages 2007
Effects of salts on protein-surface interactions: applications for column chromatography Fulltext Access 14 Pages 2007
Antibacterial Activity of Contact Lenses Bearing Surface-Immobilized Layers of Intact Liposomes Loaded With Levofloxacin Fulltext Access 14 Pages 2007
Dextran or Hydroxyethyl Starch in Sprayfreeze-Dried Trehalose/Mannitol Microparticles Intended as Ballistic Particulate Carriers for Proteins Fulltext Access 14 Pages 2007
Development and characterization of chitosan succinate microspheres for the improved oral bioavailability of insulin Fulltext Access 14 Pages 2007
Impact of Cremophor-EL and Polysorbate-80 on Digoxin Permeability across Rat Jejunum: Delineation of Thermodynamic and Transporter Related Events Using the Reciprocal Permeability Approach Fulltext Access 14 Pages 2007
Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: Synthesis, biological evaluation, and structure–activity relationships Fulltext Access 14 Pages 2007
Preparation of tetrahydroimidazo[2,1-a]isoquinolines and their use as inhibitors of gastric acid secretion Fulltext Access 14 Pages 2007
Synthesis and structure–activity relationships of 16-modified analogs of 2-methoxyestradiol Fulltext Access 14 Pages 2007
Synthesis and antidiabetic activity of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyridines and thieno[2,3-b]pyridines Fulltext Access 14 Pages 2007
Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) δ-selective agonists Fulltext Access 14 Pages 2007
Targeting cytochrome P450 enzymes: A new approach in anti-cancer drug development Fulltext Access 14 Pages 2007
Selection, synthesis, and structure–activity relationship of tetrahydropyrido[4,3-d]pyrimidine-2,4-diones as human GnRH receptor antagonists Fulltext Access 14 Pages 2007
Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase Fulltext Access 14 Pages 2007
Synthesis and structure–activity relationship study of cytotoxic germanicane- and lupane-type 3β-O-monodesmosidic saponins starting from betulin Fulltext Access 14 Pages 2007
A library of novel hydroxamic acids targeting the metallo-protease family: Design, parallel synthesis and screening Fulltext Access 14 Pages 2007
Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist Fulltext Access 14 Pages 2007
Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of α5-inverse agonist useful tools for therapy of mnemonic damage Fulltext Access 14 Pages 2007
N6-[(Hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines: The first example of adenosine-related structures with potent agonist activity at the human A2B adenosine receptor Fulltext Access 14 Pages 2007
Simultaneous presence of unsaturation and long alkyl chain at P1′ of Ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9) inhibition as shown by molecular modelling studies Fulltext Access 14 Pages 2007
Analytical methodologies for the determination of omeprazole: An overview Fulltext Access 14 Pages 2007
Selection of background electrolyte for CZE analysis by a chemometric approach: Part I. Separation of a mixture of acidic non-steroidal anti-inflammatory drugs Fulltext Access 14 Pages 2007
A study of the performance characteristics of immunoaffinity solid phase microextraction probes for extraction of a range of benzodiazepines Fulltext Access 14 Pages 2007
3D-Quantitative structure–activity relationships of synthetic antileishmanial ring-substituted ether phospholipids Fulltext Access 14 Pages 2007
Design, synthesis and biological activity of selective and orally available TF/FVIIa complex inhibitors containing non-amidine P1 ligands Fulltext Access 14 Pages 2007
Synthesis, structure, and estrogenic activity of 4-amino-3-(2-methylbenzyl)coumarins on human breast carcinoma cells Fulltext Access 14 Pages 2007
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates Fulltext Access 14 Pages 2007
Discovery of 1,1-dioxo-1,2,6-thiadiazine-5-carboxamide derivatives as cannabinoid-like molecules with agonist and antagonist activity Fulltext Access 14 Pages 2007
Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs Fulltext Access 14 Pages 2007
Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site Fulltext Access 14 Pages 2007
Synthesis of bisaminoacylated pdCpAs and tandemly activated transfer RNAs Fulltext Access 14 Pages 2007
Dual irreversible kinase inhibitors: Quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2 Fulltext Access 14 Pages 2007
Design, synthesis, and preliminary in vitro and in silico antiviral activity of [4,7]phenantrolines and 1-oxo-1,4-dihydro-[4,7]phenantrolines against single-stranded positive-sense RNA genome viruses Fulltext Access 14 Pages 2007
The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: A novel class of potent MCH-R1 antagonists Fulltext Access 14 Pages 2007
Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase Fulltext Access 14 Pages 2007
1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: Synthesis, analgesic-anti-inflammatory and antimicrobial activities Fulltext Access 14 Pages 2007
A synthetic method for diversification of the P1′ substituent in phosphinic dipeptides as a tool for exploration of the specificity of the S1′ binding pockets of leucine aminopeptidases Fulltext Access 14 Pages 2007