Lectin-conjugated PLGA nanoparticles loaded with thymopentin: Ex vivo bioadhesion and in vivo biodistribution Fulltext Access 12 Pages 2007
Circadian rhythms in cardiac arrhythmias and opportunities for their chronotherapy Fulltext Access 12 Pages 2007
Physiology and pharmacology of the brushtail possum gastrointestinal tract: Relationship to the human gastrointestinal tract Fulltext Access 12 Pages 2007
Brain delivery of vasoactive intestinal peptide enhanced with the nanoparticles conjugated with wheat germ agglutinin following intranasal administration Fulltext Access 12 Pages 2007
Mitochondriotropics: A review of their mode of action, and their applications for drug and DNA delivery to mammalian mitochondria Fulltext Access 12 Pages 2007
Concurrent delivery of dexamethasone and VEGF for localized inflammation control and angiogenesis Fulltext Access 12 Pages 2007
Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer–Dox–AGM in breast cancer cells Fulltext Access 12 Pages 2007
Bioreversibly crosslinked polyplexes of PEI and high molecular weight PEG show extended circulation times in vivo Fulltext Access 12 Pages 2007
Direct comparison of two pegylated liposomal doxorubicin formulations: Is AUC predictive for toxicity and efficacy? Fulltext Access 12 Pages 2007
“Alternative” endocytic mechanisms exploited by pathogens: New avenues for therapeutic delivery? Fulltext Access 12 Pages 2007
Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit Fulltext Access 12 Pages 2007
Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors Fulltext Access 12 Pages 2007
Synthesis of novel quinolone and quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides: A late-stage diversification approach to potent 5HT1B antagonists Fulltext Access 12 Pages 2007
ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: Identification, in vitro pharmacology, pharmacokinetic and biodistribution studies Fulltext Access 12 Pages 2007
Synthesis of novel potent hepatitis C virus NS3 protease inhibitors: Discovery of 4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid as a N-acyl-l-hydroxyproline bioisostere Fulltext Access 12 Pages 2007
Chemoenzymatic synthesis and antimicrobial activity evaluation of monoglucosyl diglycerides Fulltext Access 12 Pages 2007
Programmable oligomers targeting 5′-GGGG-3′ in the minor groove of DNA and NF-κB binding inhibition Fulltext Access 12 Pages 2007
Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues Fulltext Access 12 Pages 2007
Enhancing absorption of fluorescein and LHRH across hindgut epithelia in a marsupial, the common brushtail possum Trichosurus vulpecula Fulltext Access 12 Pages 2007
Prediction of the Onset of Crystallization of Amorphous Sucrose Below the Calorimetric Glass Transition Temperature from Correlations with Mobility Fulltext Access 12 Pages 2007
Crystallization Pathways and Kinetics of Carbamazepine–Nicotinamide Cocrystals from the Amorphous State by In Situ Thermomicroscopy, Spectroscopy, and Calorimetry Studies Fulltext Access 12 Pages 2007
Energetic Aspects of Diclofenac Acid in Crystal Modifications and in Solutions—Mechanism of Solvation, Partitioning and Distribution Fulltext Access 12 Pages 2007
PHARMACEUTICS, PREFORMULATION ANDDRUG DELIVERY : Relationships between Structural and Thermal Properties of Anhydrous and Solvated Crystalline Forms of Brodimoprim Fulltext Access 12 Pages 2007
On the determination of the time delay in reaching the steady state drug concentration in the organ compared to plasma Fulltext Access 12 Pages 2007
Drug product characterization by Macropixel Analysis of chemical images Fulltext Access 12 Pages 2007
Protein isolated from biopharmaceutical formulations cannot be used for comparative studies: Followâup to “a case study using Epoetin Alfa from Epogen and EPREX” Fulltext Access 12 Pages 2007
Characterization and Selective Crystallization of Famotidine Polymorphs Fulltext Access 12 Pages 2007
Cholesterol as a bilayer anchor for PEGylation and targeting ligand in folateâreceptorâtargeted liposomes Fulltext Access 12 Pages 2007
Single-Droplet Evaporation Kinetics and Particle Formation in an Acoustic Levitator. Part 2: Drying Kinetics and Particle Formation From Microdroplets of Aqueous Mannitol, Trehalose, or Catalase Fulltext Access 12 Pages 2007
Physicochemical and biological study of selected hydrophobic polyethylenimine-based polycationic liposomes and their complexes with DNA Fulltext Access 12 Pages 2007
Quantitation of Aggregate Levels in a Recombinant Humanized Monoclonal Antibody Formulation by Size-Exclusion Chromatography, Asymmetrical Flow Field Flow Fractionation, and Sedimentation Velocity Fulltext Access 12 Pages 2007
Solid State Chemistry of Proteins: I. Glass Transition Behavior in Freeze Dried Disaccharide Formulations of Human Growth Hormone (HGH) Fulltext Access 12 Pages 2007
Utilization of a Modified SpecialâCubic Design and an Electronic Tongue for Bitterness Masking Formulation Optimization Fulltext Access 12 Pages 2007
Effect of Polymer Molecular Weight on the Production of Drug Nanoparticles Fulltext Access 12 Pages 2007
Preparation and characterization of free mixed-film of pectin/chitosan/Eudragit® RS intended for sigmoidal drug delivery Fulltext Access 12 Pages 2007
Optimisation of polyherbal gels for vaginal drug delivery by Box-Behnken statistical design Fulltext Access 12 Pages 2007
Influence of processing parameters and formulation factors on the drug release from tablets powder-coated with Eudragit® L 100-55 Fulltext Access 12 Pages 2007
A model describing the effect of enzymatic degradation on drug release from collagen minirods Fulltext Access 12 Pages 2007
Structure-based design of TACE selective inhibitors: Manipulations in the S1′–S3′ pocket Fulltext Access 12 Pages 2007
Novel C2–C3′ N-peptide linked macrocyclic taxoids. Part 2: Synthesis and biological activities of docetaxel analogues with a peptide side chain at C2 and their macrocyclic derivatives Fulltext Access 12 Pages 2007
Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase Fulltext Access 12 Pages 2007
Discovery of 7α-substituted dihydrotestosterones as androgen receptor pure antagonists and their structure–activity relationships Fulltext Access 12 Pages 2007
A Pd(0) based cross-coupling approach to the synthesis of 2-amidopurines and their evaluation as CDK inhibitors Fulltext Access 12 Pages 2007
Novel C2-purine position analogs of nitrobenzylmercaptopurine riboside as human equilibrative nucleoside transporter 1 inhibitors Fulltext Access 12 Pages 2007
Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes Fulltext Access 12 Pages 2007
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli Fulltext Access 12 Pages 2007
Discovering benzamide derivatives as glycogen phosphorylase inhibitors and their binding site at the enzyme Fulltext Access 12 Pages 2007
7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT1A, 5-HT2A, and 5-HT7 serotonin receptor ligands Fulltext Access 12 Pages 2007
Synthesis and structure-antibacterial activity relationship investigation of isomeric 2,3,5-substituted perhydropyrrolo[3,4-d]isoxazole-4,6-diones Fulltext Access 12 Pages 2007
Exploring DNA topoisomerase I inhibition by the benzo[c]phenanthridines fagaronine and ethoxidine using steered molecular dynamics Fulltext Access 12 Pages 2007
Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine Fulltext Access 12 Pages 2007
Exploration of linear modelling techniques and their combination with multivariate adaptive regression splines to predict gastro-intestinal absorption of drugs Fulltext Access 12 Pages 2007
Generic ciprofloxacin tablets contain the stated amount of drug and different impurity profiles: A 19F, 1H and DOSY NMR analysis Fulltext Access 12 Pages 2007
Robustness testing of a chiral NACE method for R-timolol determination in S-timolol maleate and uncertainty assessment from quantitative data Fulltext Access 12 Pages 2007
High-throughput quantitation of nefazodone and its metabolites in human plasma by high flow direct-injection LC-MS/MS Fulltext Access 12 Pages 2007
Column selection for pharmaceutical analyses based on a column classification using four test parameters Fulltext Access 12 Pages 2007
Harmonization of strategies for the validation of quantitative analytical procedures: A SFSTP proposal – Part II Fulltext Access 12 Pages 2007
An overview of chromatographic methods coupled with mass spectrometric detection for determination of angiotensin-converting enzyme inhibitors in biological material Fulltext Access 12 Pages 2007
Tricyclic isoxazolines: Identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and α2-adrenoceptor antagonism Fulltext Access 12 Pages 2007
Synthesis and evaluation of unsaturated caprolactams as interleukin-1β converting enzyme (ICE) inhibitors Fulltext Access 12 Pages 2007
In vitro efficiency of new acridyl derivatives against Plasmodium falciparum Fulltext Access 12 Pages 2007
Preparation of cyclic 2â²,3â²-carbamate derivatives of erythromycin macrolide antibiotics Fulltext Access 12 Pages 2007
Novel thyroid hormone receptor antagonists with an N-alkylated diphenylamine skeleton Fulltext Access 12 Pages 2007
Synthetic chalcones, flavanones, and flavones as antitumoral agents: Biological evaluation and structure–activity relationships Fulltext Access 12 Pages 2007
E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: A topographical study of some novel potent cytotoxins Fulltext Access 12 Pages 2007
A new therapeutic approach in Alzheimer disease: Some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics Fulltext Access 12 Pages 2007
Synthesis and activity studies of analogues of the rat selective toxicant norbormide Fulltext Access 12 Pages 2007
Novel 1-oxyl-2-substitutedphenyl-4,4,5,5-tetramethylimidazolines: Synthesis, selectively analgesic action, and QSAR analysis Fulltext Access 12 Pages 2007
Biological evaluation of de-O-sulfonated analogs of salacinol, the role of sulfate anion in the side chain on the α-glucosidase inhibitory activity Fulltext Access 12 Pages 2007
Synthesis and antimicrobial activity of symmetrical two-tailed dendritic tricarboxylato amphiphiles Fulltext Access 12 Pages 2007
QSAR study on permeability of hydrophobic compounds with artificial membranes Fulltext Access 12 Pages 2007
Application of LC–MS for quantitative analysis and metabolite identification of therapeutic oligonucleotides Fulltext Access 12 Pages 2007
Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors Fulltext Access 12 Pages 2007
Synthesis of new S-derivatives of clubbed triazolyl thiazole as anti-Mycobacterium tuberculosis agents Fulltext Access 12 Pages 2007
Calcitriol derivatives with two different side-chains at C-20. Part 4: Further chain modifications that alter VDR-dependent monocytic differentiation potency in human leukemia cells Fulltext Access 12 Pages 2007
Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Aβ1–42 aggregation for Alzheimer’s disease therapeutics Fulltext Access 12 Pages 2007
Glycosidic juvenogens: Derivatives bearing α,β-unsaturated ester functionalities Fulltext Access 12 Pages 2007
[(2-Phenylindol-3-yl)methylene]propanedinitriles inhibit the growth of breast cancer cells by cell cycle arrest in G2/M phase and apoptosis Fulltext Access 12 Pages 2007
Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK Fulltext Access 12 Pages 2007
Design and synthesis of pyridine–pyrazolopyridine-based inhibitors of protein kinase B/Akt Fulltext Access 12 Pages 2007
Synthesis and α1-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin Fulltext Access 12 Pages 2007