Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (TAK-802) and related compounds Fulltext Access 11 Pages 2005
Investigations of linker structure on the potency of a series of bidentate protein tyrosine phosphatase inhibitors Fulltext Access 11 Pages 2005
Cytotoxicities, cell cycle and caspase evaluations of 1,6-diaryl-3(Z)-hexen-1,5-diynes, 2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines and their derivatives Fulltext Access 11 Pages 2005
Novel anellated pyrazoloquinolin-3-ones: synthesis and in vitro BZR activity Fulltext Access 11 Pages 2005
Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa Fulltext Access 11 Pages 2005
Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases Fulltext Access 11 Pages 2005
Structure–activity relationships of tyrosinase inhibitory combinatorial library of 2,5-disubstituted-1,3,4-oxadiazole analogues Fulltext Access 11 Pages 2005
Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with β-secretase Fulltext Access 11 Pages 2005
Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent Fulltext Access 11 Pages 2005
Exploration of a binding mode of indole amide analogues as potent histone deacetylase inhibitors and 3D-QSAR analyses Fulltext Access 11 Pages 2005
The study on the interaction between seryl-histidine dipeptide and proteins by circular dichroism and molecular modeling Fulltext Access 11 Pages 2005
Fluorinated phenylcyclopropylamines. Part 4: Effects of aryl substituents and stereochemistry on the inhibition of monoamine oxidases by 1-aryl-2-fluoro-cyclopropylamines Fulltext Access 11 Pages 2005
Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product Fulltext Access 11 Pages 2005
Novel cyclosporin derivatives featuring enhanced skin penetration despite increased molecular weight Fulltext Access 11 Pages 2005
Stereochemical influence on lipase-mediated hydrolysis and biological activity of stampidine and other stavudine phosphoramidates Fulltext Access 11 Pages 2005
Synthesis and biological relationships of 3â²,6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents Fulltext Access 11 Pages 2005
Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands Fulltext Access 11 Pages 2005
Photocontrol of nitric oxide production in cell culture using a caged isoform selective inhibitor Fulltext Access 11 Pages 2005
Oligosaccharides as inhibitors of mycobacterial arabinosyltransferases. Di- and trisaccharides containing C-3 modified arabinofuranosyl residues Fulltext Access 11 Pages 2005
Perfluorinated markers for hypoxia detection: synthesis of sulfur-containing precursors and [18F]-labelling Fulltext Access 11 Pages 2005
Predicting multiple drugs side effects with a general drug-target interaction thermodynamic Markov model Fulltext Access 11 Pages 2005
Exploring human adenosine A3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety Fulltext Access 11 Pages 2005
Cardioprotective activity of melatonin and its novel synthesized derivatives on doxorubicin-induced cardiotoxicity Fulltext Access 11 Pages 2005
Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors Fulltext Access 11 Pages 2005
α-Glucosidase inhibition of 6-hydroxyflavones. Part 3: Synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as α-glucosidase inhibitors Fulltext Access 11 Pages 2005
Synthesis and potent antimicrobial activity of some novel methyl or ethyl 1H-benzimidazole-5-carboxylates derivatives carrying amide or amidine groups Fulltext Access 11 Pages 2005
Identification of peptide ligands for malignancy- and growth-regulating galectins using random phage-display and designed combinatorial peptide libraries Fulltext Access 11 Pages 2005
N-Oxide analogs of WAY-100635: new high affinity 5-HT1A receptor antagonists Fulltext Access 11 Pages 2005
Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases Fulltext Access 11 Pages 2005
2-Aryl-8-chloro-1,2,4-triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists Fulltext Access 11 Pages 2005
Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa Fulltext Access 11 Pages 2005
1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), α1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics Fulltext Access 11 Pages 2005
Synthesis and initial PET imaging of new potential dopamine D3 receptor radioligands (E)-4,3,2-[11C]methoxy-N-4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl-cinnamoylamides Fulltext Access 11 Pages 2005
Biomimetic synthesis of acid-sensitive (−)- and (+)-caparrapi oxides, (−)- and (+)-8-epicaparrapi oxides, and (+)-dysifragin induced by artificial cyclases Fulltext Access 11 Pages 2005
Prostate cancer PET bioprobes: Synthesis of [18F]-radiolabeled hydroxyflutamide derivatives Fulltext Access 11 Pages 2005
Hydrophobic and electronic factors in the design of dialkylglycine decarboxylase mimics Fulltext Access 11 Pages 2005
Binding studies and GRIND/ALMOND-based 3D QSAR analysis of benzothiazine type KATP-channel openers Fulltext Access 11 Pages 2005
Combined NMR-crystallographic and modelling investigation of the inclusion of molsidomine into α-, β- and γ-cyclodextrins Fulltext Access 11 Pages 2005
Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes Fulltext Access 11 Pages 2005
New potent 5-substituted benzofuroxans as inhibitors of Trypanosoma cruzi growth: Quantitative structure–activity relationship studies Fulltext Access 11 Pages 2005
Branched aminoglycosides: Biochemical studies and antibacterial activity of neomycin B derivatives Fulltext Access 11 Pages 2005
Validation of a histamine H3 receptor model through structure–activity relationships for classical H3 antagonists Fulltext Access 11 Pages 2005
Chiral anthracene and anthrone templates as stereocontrolling elements in Diels–Alder/retro Diels–Alder sequences Fulltext Access 11 Pages 2005
Genistein derivatives as selective estrogen receptor modulators: Sonochemical synthesis and in vivo anti-osteoporotic action Fulltext Access 11 Pages 2005
QSAR studies on 1-phenylbenzimidazoles as inhibitors of the platelet-derived growth factor Fulltext Access 11 Pages 2005
Synthesis and antibacterial activity of new N-linked 5-triazolylmethyl oxazolidinones Fulltext Access 11 Pages 2005
Synthetic modification of the 2-oxypropionic acid moiety in 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469), and consequent antitumor effects. Part 4 Fulltext Access 11 Pages 2005
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2 Fulltext Access 11 Pages 2005
Synthesis of glycoporphyrin derivatives and their antiviral activity against herpes simplex virus types 1 and 2 Fulltext Access 11 Pages 2005
Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora Fulltext Access 11 Pages 2005
Selection of excipients for extended release formulations of glipizide through drug-excipient compatibility testing Fulltext Access 12 Pages 2005
Validation of immunoassays used to assess immunogenicity to therapeutic monoclonal antibodies Fulltext Access 12 Pages 2005
Application of HPLC and HPTLC for the simultaneous determination of tizanidine and rofecoxib in pharmaceutical dosage form Fulltext Access 12 Pages 2005
Simultaneous determination of ingredients in a cold medicine by cyclodextrin-modified microemulsion electrokinetic chromatography Fulltext Access 12 Pages 2005
Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I Fulltext Access 12 Pages 2005
Exploration of orally available calpain inhibitors: Peptidyl α-ketoamides containing an amphiphile at P3 site Fulltext Access 12 Pages 2005
Ginkgolides and bilobalide: Their physical, chromatographic and spectroscopic properties Fulltext Access 12 Pages 2005
Benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives as potential antitrypanosomal drugs. Part 3: Substituents-clustering methodology in the search for new active compounds Fulltext Access 12 Pages 2005
Methyltrioxorhenium catalysed synthesis of highly oxidised aryltetralin lignans with anti-topoisomerase II and apoptogenic activities Fulltext Access 12 Pages 2005
Triketones active against antibiotic-resistant bacteria: Synthesis, structure–activity relationships, and mode of action Fulltext Access 12 Pages 2005
Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists Fulltext Access 12 Pages 2005
Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1α,25-dihydroxyvitamin D3 Fulltext Access 12 Pages 2005
Relationships between structure and high-throughput screening permeability of diverse drugs with artificial membranes: Application to prediction of Caco-2 cell permeability Fulltext Access 12 Pages 2005
Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity Fulltext Access 12 Pages 2005
Geldanamycin derivative inhibition of HGF/SF-mediated Met tyrosine kinase receptor-dependent urokinase-plasminogen activation Fulltext Access 12 Pages 2005
Preventive effects of soyasapogenol B derivatives on liver injury in a concanavalin A-induced hepatitis model Fulltext Access 12 Pages 2005
Aminoethyl-substituted indole-3-acetic acids for the preparation of tagged and carrier-linked auxin Fulltext Access 12 Pages 2005
Tricyclic pyrazoles. Part 2: Synthesis and biological evaluation of novel 4,5-dihydro-1H-benzo[g]indazole-based ligands for cannabinoid receptors Fulltext Access 12 Pages 2005
A topological substructural approach applied to the computational prediction of rodent carcinogenicity Fulltext Access 12 Pages 2005
Synthesis and antitubercular activities of bis-glycosylated diamino alcohols Fulltext Access 12 Pages 2005
Structure–activity studies of 3′-4′-dichloro-meperidine analogues at dopamine and serotonin transporters Fulltext Access 12 Pages 2005
Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities Fulltext Access 12 Pages 2005
Synthesis of 2-(aminocarbonylmethylthio)-1H-imidazoles as novel Capravirine analogues Fulltext Access 12 Pages 2005
Design, synthesis and evaluation of carbazole derivatives as PPARα/γ dual agonists and antioxidants Fulltext Access 12 Pages 2005
General synthesis and biological evaluation of α-1-C-substituted derivatives of fagomine (2-deoxynojirimycin-α-C-glycosides) Fulltext Access 12 Pages 2005
Differences between the structural requirements for ABA 8′-hydroxylase inhibition and for ABA activity Fulltext Access 12 Pages 2005
New antitubulin derivatives in the combretastatin A4 series: synthesis and biological evaluation Fulltext Access 12 Pages 2005
Stereocontrolled synthesis of anticancer β-lactams via the Staudinger reaction Fulltext Access 12 Pages 2005
Synthesis and antibody-binding studies of a series of parasite fuco-oligosaccharides Fulltext Access 12 Pages 2005
A novel non-stochastic quadratic fingerprints-based approach for the ‘in silico’ discovery of new antitrypanosomal compounds Fulltext Access 12 Pages 2005
Synthesis and biological evaluation of penam sulfones as inhibitors of β-lactamases Fulltext Access 12 Pages 2005
Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes Fulltext Access 12 Pages 2005
In silico ADME modelling: prediction models for blood–brain barrier permeation using a systematic variable selection method Fulltext Access 12 Pages 2005
Synthesis and evaluation of molluscicidal and larvicidal activities of some novel enaminones derived from 4-hydroxyquinolinones: Part IX Fulltext Access 12 Pages 2005
A novel method of estimation of lipophilicity using distance-based topological indices: dominating role of equalized electronegativity Fulltext Access 12 Pages 2005