Influence of Chitosan Crosslinking on Bitterness of Mefloquine Hydrochloride Microparticles Using Central Composite Design Fulltext Access 14 Pages 2009
N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a “chemical knock-out equivalent” to assess the impact of efflux transporters on oral drug absorption in the rat Fulltext Access 14 Pages 2009
Polymorphism of Progesterone: Relative Stabilities of the Orthorhombic Phases I and II Inferred from Topological and Experimental Pressure-Temperature Phase Diagrams Fulltext Access 14 Pages 2009
Quantitation of protein particles in parenteral solutions using micro-flow imaging Fulltext Access 14 Pages 2009
Characterization of the photodegradation of a human IgG1 monoclonal antibody formulated as a high-concentration liquid dosage form Fulltext Access 14 Pages 2009
Impact of sucrose level on storage stability of proteins in freeze-dried solids: I. correlation of protein–sugar interaction with native structure preservation Fulltext Access 14 Pages 2009
Novel methods for the assessment of miscibility of amorphous drug-polymer dispersions Fulltext Access 14 Pages 2009
Rapid freeze-drying cycle optimization using computer programs developed based on heat and mass transfer models and facilitated by tunable diode laser absorption spectroscopy (TDLAS) Fulltext Access 14 Pages 2009
Simultaneously manufactured nano-in-micro (SIMANIM) particles for dry-powder modified-release delivery of antibodies Fulltext Access 14 Pages 2009
Reversal of Multidrug Resistance by Methoxypolyethylene Glycol-Block-Polycaprolactone Diblock Copolymers Through the Inhibition of P-Glycoprotein Function Fulltext Access 14 Pages 2009
Liquid Crystalline Systems of Phytantriol and Glyceryl Monooleate Containing a Hydrophilic Protein: Characterisation, Swelling and Release Kinetics Fulltext Access 14 Pages 2009
Evaluation of polyanhydride microspheres for basal insulin delivery: Effect of copolymer composition and zinc salt on encapsulation, in vitro release, stability, in vivo absorption and bioactivity in diabetic rats Fulltext Access 14 Pages 2009
Combined Effects of Wetting, Drying, and Microcrystalline Cellulose Type on the Mechanical Strength and Disintegration of Pellets Fulltext Access 14 Pages 2009
Characterization of MoistureâProtective Polymer Coatings Using Differential Scanning Calorimetry and Dynamic Vapor Sorption Fulltext Access 14 Pages 2009
The Role of Force Control Agents in High-Dose Dry Powder Inhaler Formulations Fulltext Access 14 Pages 2009
Insulin Loaded PLGA Microspheres: Effect of Zinc Salts on Encapsulation, Release, and Stability Fulltext Access 14 Pages 2009
Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Diclofenac Sodium and Diclofenac Potassium Fulltext Access 14 Pages 2009
Synthesis, Characterization and In Vivo Activity of Salmon Calcitonin Coconjugated With Lipid and Polyethylene Glycol Fulltext Access 14 Pages 2009
New chitosan derivatives for the preparation of rokitamycin loaded microspheres designed for ocular or nasal administration Fulltext Access 14 Pages 2009
Mechanistic evaluation of alginate-HEC gelisphere compacts for controlled intrastriatal nicotine release in Parkinson's disease Fulltext Access 14 Pages 2009
Investigation of the effects of altered receptor binding activity on the clearance of erythropoiesis-stimulating proteins: Nonerythropoietin receptor-mediated pathways may play a major role Fulltext Access 14 Pages 2009
Solid state mechanochemical simultaneous activation of the constituents of the Silybum marianum phytocomplex with crosslinked polymers* Fulltext Access 14 Pages 2009
Heterogeneity of Commercial Recombinant Human Growth Hormone (r-hGH) Preparations Containing a Thioether Variant Fulltext Access 14 Pages 2009
An examination of binding motifs associated with inter-particle interactions between facetted nano-crystals of acetylsalicylic acid and ascorbic acid through the application of molecular grid-based search methods Fulltext Access 14 Pages 2009
Manipulating Hydrate Formation During High Shear Wet Granulation Using Polymeric Excipients Fulltext Access 14 Pages 2009
Cholesterol-Mediated Activation of P-Glycoprotein: Distinct Effects on Basal and Drug-Induced ATPase Activities Fulltext Access 14 Pages 2009
Liquid chromatography–mass spectrometry in in vitro drug metabolite screening Fulltext Access 14 Pages 2009
Tolerability of atypical antipsychotics in the treatment of adults with schizophrenia or bipolar disorder: A mixed treatment comparison of randomized controlled trials Fulltext Access 15 Pages 2009
Effects of intravenous patient-controlled analgesia with buprenorphine and morphine alone and in combination during the first 12 postoperative hours: A randomized, double-blind, four-arm trial in adults undergoing abdominal surgery Fulltext Access 15 Pages 2009
Efficacy and tolerability of intranasal fentanyl spray 50 to 200 μg for breakthrough pain in patients with cancer: A phase III, multinational, randomized, double-blind, placebo-controlled, crossover trial with a 10-month, open-label extension treatment pe Fulltext Access 15 Pages 2009
Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis Fulltext Access 15 Pages 2009
Efficacy and tolerability of atorvastatin/fenofibrate fixed-dose combination tablet compared with atorvastatin and fenofibrate monotherapies in patients with dyslipidemia: A 12-week, multicenter, double-blind, randomized, parallel-group study Fulltext Access 15 Pages 2009
Effect of the CYP3A inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of bortezomib in patients with advanced solid tumors: A prospective, multicenter, open-label, randomized, two-way crossover drug—drug interaction study Fulltext Access 15 Pages 2009
Tolerability outcomes of a multicenter, observational, open-label, drug-surveillance study in patients with type 2 diabetes mellitus treated with pioglitazone for 2 years * Fulltext Access 15 Pages 2009
Results of a Markov model analysis to assess the cost-effectiveness of a single tablet of fixed-dose amlodipine and atorvastatin for the primary prevention of cardiovascular disease in Korea Fulltext Access 15 Pages 2009
Pharmacokinetics of duloxetine hydrochloride enteric-coated tablets in healthy Chinese volunteers: A randomized, open-label, single- and multiple-dose study Fulltext Access 15 Pages 2009
Aryl hydrocarbon receptor biology and xenobiotic responses in hematopoietic progenitor cells Fulltext Access 15 Pages 2009
Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation — a tale of three gases! Fulltext Access 15 Pages 2009
Effects of the dopamine stabilizer, OSU-6162, on brain stimulation reward and on quinpirole-induced changes in reward and locomotion Fulltext Access 15 Pages 2009
Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: Role of NF-κB, p38 and JNK MAPK pathway Fulltext Access 15 Pages 2009
Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats Fulltext Access 15 Pages 2009
An update on preventive and regenerative therapies in diabetes mellitus Fulltext Access 15 Pages 2009
Regulation of GABAA receptor membrane trafficking and synaptic localization Fulltext Access 15 Pages 2009
Attacking the multi-tiered proteolytic pathology of COPD: New insights from basic and translational studies Fulltext Access 15 Pages 2009
Gabapentin for the treatment of hot flashes in women with natural or tamoxifen-induced menopause: A systematic review and meta-analysis Fulltext Access 15 Pages 2009
The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs Fulltext Access 15 Pages 2009
White paper on designing a risk evaluation and mitigation strategies (REMS) system to optimize the balance of patient access, medication safety, and impact on the health care system Fulltext Access 15 Pages 2009
Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis Fulltext Access 15 Pages 2009
A framework for planning and critiquing medication compliance and persistence research using prospective study designs Fulltext Access 15 Pages 2009
Colesevelam hydrochloride for the treatment of type 2 diabetes mellitus Fulltext Access 15 Pages 2009
Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system Fulltext Access 15 Pages 2009
Effect of the pH grade of silicates on chemical stability of coground amorphous quinapril hydrochloride and its stabilization using pH-modifiers Fulltext Access 15 Pages 2009
Silicone Oil- and Agitation-Induced Aggregation of a Monoclonal Antibody in Aqueous Solution Fulltext Access 15 Pages 2009
A Near-Infrared Spectroscopic Investigation of Relative Density and Crushing Strength in Four-Component Compacts Fulltext Access 15 Pages 2009
Lung-Specific Delivery of Paclitaxel by Chitosan-Modified PLGA Nanoparticles Via Transient Formation of Microaggregates Fulltext Access 15 Pages 2009
Characterization of chitin-metal silicates as binding superdisintegrants Fulltext Access 15 Pages 2009
Polyethylene sebacate: Genotoxicity, mutagenicity evaluation and application in periodontal drug delivery system Fulltext Access 15 Pages 2009
Prediction of the possibility of the secondary peaks of iv bolus drug plasma concentration time curve by the model that directly takes into account the transit time through the organ Fulltext Access 15 Pages 2009
Comparison of Single Pot and Multiphase High Shear Wet Granulation Processes Related to Excipient Composition Fulltext Access 15 Pages 2009
Effect of formulation parameters and drug-polymer interactions on drug release from starch acetate matrix tablets Fulltext Access 15 Pages 2009
Monitoring intracellular labile iron pools: A novel fluorescent iron(iii) sensor as a potential non-invasive diagnosis tool Fulltext Access 15 Pages 2009
Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerations Fulltext Access 15 Pages 2009
Decision support methods for the detection of adverse events in post-marketing data Fulltext Access 15 Pages 2009
α7-Nicotinic receptor antagonists at the beginning of a clinical era for NSCLC and Mesothelioma? Fulltext Access 15 Pages 2009
Development of Clinical Dosage Forms for a Poorly Water-Soluble Drug II: Formulation and Characterization of a Novel Solid Microemulsion Preconcentrate System for Oral Delivery of a Poorly Water-Soluble Drug Fulltext Access 15 Pages 2009
Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent Fulltext Access 15 Pages 2009
A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells Fulltext Access 15 Pages 2009
The inhibition of TNF-α-induced NF-κB activation by marine natural products Fulltext Access 15 Pages 2009
Synergy research: Vitamins and secondary plant components in the maintenance of the redox-homeostasis and in cell signaling Fulltext Access 15 Pages 2009
GABAA receptors and their associated proteins: Implications in the etiology and treatment of schizophrenia and related disorders Fulltext Access 15 Pages 2009
Modulation of GABAergic and glutamatergic transmission by ethanol in the developing neocortex: An in vitro test of the excessive inhibition hypothesis of fetal alcohol spectrum disorder Fulltext Access 15 Pages 2009
Tumor necrosis factor α induces γ-glutamyltransferase expression via nuclear factor-κB in cooperation with Sp1 Fulltext Access 15 Pages 2009
Determination of Mean Residence Time of Drug in Plasma and the Influence of the Initial Drug Elimination and Distribution on the Calculation of Pharmacokinetic Parameters Fulltext Access 15 Pages 2009
Differential Effect of Ethanol and Hydrogen Peroxide on Barrier Function and Prostaglandin E2 Release in Differentiated Cacoâ2 Cells: Selective Prevention by Growth Factors Fulltext Access 15 Pages 2009
Pharmacokinetics of Amitriptyline and One of Its Metabolites, Nortriptyline, in Rats: Little Contribution of Considerable Hepatic First-Pass Effect to Low Bioavailability of Amitriptyline Due to Great Intestinal First-Pass Effect Fulltext Access 15 Pages 2009
Distribution of Saquinavir, Methadone, and Buprenorphine in Maternal Brain, Placenta, and Fetus During Two Different Gestational Stages of Pregnancy in Mice Fulltext Access 15 Pages 2009
Sulphonylurea physicochemical-pharmacokinetic relationships in the pancreas and liver Fulltext Access 15 Pages 2009
Quality-By-Design (QbD): An Integrated Approach for Evaluation of Powder Blending Process Kinetics and Determination of Powder Blending End-point Fulltext Access 15 Pages 2009