Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling Fulltext Access 11 Pages 2008
Using behaviour to predict stroke severity in conscious rats: Post-stroke treatment with 3′, 4′-dihydroxyflavonol improves recovery Fulltext Access 11 Pages 2008
Pharmacological profile of store-operated Ca2+ entry in intrapulmonary artery smooth muscle cells Fulltext Access 11 Pages 2008
Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor Fulltext Access 11 Pages 2008
Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R Fulltext Access 11 Pages 2008
The central corticotropin releasing factor system during development and adulthood Fulltext Access 11 Pages 2008
Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: Role of NMDA receptor activation and NMDA dependent calcium entry Fulltext Access 11 Pages 2008
Denbinobin, a naturally occurring 1,4-phenanthrenequinone, inhibits HIV-1 replication through an NF-κB-dependent pathway Fulltext Access 11 Pages 2008
Tumor necrosis factor α inhibits erythroid differentiation in human erythropoietin-dependent cells involving p38 MAPK pathway, GATA-1 and FOG-1 downregulation and GATA-2 upregulation Fulltext Access 11 Pages 2008
Efficacy of therapeutic intervention with an oral ether–lipid analogue of cidofovir (CMX001) in a lethal mousepox model Fulltext Access 11 Pages 2008
Porcine plasma ficolin binds and reduces infectivity of porcine reproductive and respiratory syndrome virus (PRRSV) in vitro Fulltext Access 11 Pages 2008
Sargaquinoic acid and sargachromenol, extracts of Sargassum sagamianum, induce apoptosis in HaCaT cells and mice skin: Its potentiation of UVB-induced apoptosis Fulltext Access 11 Pages 2008
Oligonucleotide antiviral therapeutics: Antisense and RNA interference for highly pathogenic RNA viruses Fulltext Access 11 Pages 2008
Antinociceptive effect of novel trihalomethyl-substituted pyrazoline methyl esters in formalin and hot-plate tests in mice Fulltext Access 11 Pages 2008
Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy Fulltext Access 11 Pages 2008
Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activity Fulltext Access 11 Pages 2008
GABAA receptor pharmacology of fluorinated derivatives of the novel sedative-hypnotic pyrazolopyrimidine indiplon Fulltext Access 11 Pages 2008
PKC and MAPK signalling pathways regulate vascular endothelin receptor expression Fulltext Access 11 Pages 2008
Methacholine-induced pulmonary gas trapping in a mouse model of allergic asthma: Effect of inhaled budesonide and ciglitazone Fulltext Access 11 Pages 2008
Preclinical pharmacology profile of CS-706, a novel cyclooxygenase-2 selective inhibitor, with potent antinociceptive and anti-inflammatory effects Fulltext Access 11 Pages 2008
Interactions of attention-deficit/hyperactivity disorder therapeutic agents with the efflux transporter P-glycoprotein Fulltext Access 11 Pages 2008
Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells Fulltext Access 12 Pages 2008
Validity, reliability, and responsiveness of the work productivity and activity impairment questionnaire in Crohn's disease Fulltext Access 12 Pages 2008
Benefits and risks of clopidogrel use in patients with coronary artery disease: Evidence from randomized studies and registries Fulltext Access 12 Pages 2008
Annexin A1 and the formyl peptide receptor family: neuroendocrine and metabolic aspects Fulltext Access 12 Pages 2008
Neurotransmitters activate T-cells and elicit crucial functions via neurotransmitter receptors Fulltext Access 12 Pages 2008
Sensing the microenvironment of the central nervous system: immune cells in the central nervous system and their pharmacological manipulation Fulltext Access 12 Pages 2008
Low fresh gas flow balanced anesthesia versus target controlled intravenous infusion anesthesia in laparoscopic cholecystectomy: A cost-minimization analysis Fulltext Access 12 Pages 2008
Practical management of cutaneous reactions to the methylphenidate transdermal system: Recommendations from a dermatology expert panel consensus meeting * Fulltext Access 12 Pages 2008
Cost-effectiveness of palivizumab against respiratory syncytial viral infection in high-risk children in Austria Fulltext Access 12 Pages 2008
Combination therapy versus monotherapy as initial treatment for stage 2 hypertension: A prespecified subgroup analysis of a community-based, randomized, open-label trial Fulltext Access 12 Pages 2008
Pharmacokinetic properties and tolerability of bevirimat and atazanavir in healthy volunteers: An open-label, parallel-group study Fulltext Access 12 Pages 2008
Coadministration of valsartan 160 and 320 mg and simvastatin 20 and 40 mg in patients with hypertension and hypercholesterolemia: A multicenter, 12-week, double-blind, double-dummy, parallel-group superiority study Fulltext Access 12 Pages 2008
Validity, reliability, and clinical importance of change in a 0—10 numeric rating scale measure of spasticity: a post hoc analysis of a randomized, double-blind, placebo-controlled trial Fulltext Access 12 Pages 2008
Weight change associated with the use of migraine-preventive medications Fulltext Access 12 Pages 2008
Comparison of the effectiveness and tolerability of lidocaine patch 5% versus celecoxib for osteoarthritis-related knee pain: Post hoc analysis of a 12 week, prospective, randomized, active-controlled, open-label, parallel-group trial in adults Fulltext Access 12 Pages 2008
Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies Fulltext Access 12 Pages 2008
The As and Ds of stress: Metabolic, morphological and behavioral consequences Fulltext Access 12 Pages 2008
Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair Fulltext Access 12 Pages 2008
Diabetes and other vascular risk factors for dementia: Which factor matters most? A systematic review Fulltext Access 12 Pages 2008
Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: Involvement of adenosine receptors Fulltext Access 12 Pages 2008
Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators Fulltext Access 12 Pages 2008
Thermodynamic analysis does not allow discrimination of agonists and antagonists at human CCK2S-receptors Fulltext Access 12 Pages 2008
Mechanisms underlying the nociceptive and inflammatory responses induced by trypsin in the mouse paw Fulltext Access 12 Pages 2008
Sulfated glucosamine inhibits oxidation of biomolecules in cells via a mechanism involving intracellular free radical scavenging Fulltext Access 12 Pages 2008
Blocking melanin-concentrating hormone MCH1 receptor affects rat sleep–wake architecture Fulltext Access 12 Pages 2008
Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice Fulltext Access 12 Pages 2008
Structure and sequence motifs of siRNA linked with in vitro down-regulation of morbillivirus gene expression Fulltext Access 12 Pages 2008
In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases Fulltext Access 12 Pages 2008
The effect of thiopurine drugs on DNA methylation in relation to TPMT expression Fulltext Access 12 Pages 2008
A benzodiazepines derived compound, 4-(3-chlorophenyl)-1,3-dihydronaphtho [2,3-b][1,4]diazepin-2-one (ND700C), inhibits fMLP-induced superoxide anion release by activating protein phosphatase 2A in human neutrophils Fulltext Access 12 Pages 2008
Jingzhaotoxin-II, a novel tarantula toxin preferentially targets rat cardiac sodium channel Fulltext Access 12 Pages 2008
Kinetic stabilization of microtubule dynamic instability by benomyl increases the nuclear transport of p53 Fulltext Access 12 Pages 2008
Pharmacology of 5HT2C receptor-mediated ERK1/2 phosphorylation: Agonist-specific activation pathways and the impact of RNA editing Fulltext Access 12 Pages 2008
Oleanolic acid derivative NPLC441 potently stimulates glucose transport in 3T3-L1 adipocytes via a multi-target mechanism Fulltext Access 12 Pages 2008
Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions Fulltext Access 12 Pages 2008
Current and future antiviral therapy of severe seasonal and avian influenza Fulltext Access 12 Pages 2008
Animal models of highly pathogenic RNA viral infections: Hemorrhagic fever viruses Fulltext Access 12 Pages 2008
C3H/HeN mouse model for the evaluation of antiviral agents for the treatment of Venezuelan equine encephalitis virus infection Fulltext Access 12 Pages 2008
Magnolol elicits activation of the extracellular signal-regulated kinase pathway by inducing p27KIP1-mediated G2/M-phase cell cycle arrest in human urinary bladder cancer 5637 cells Fulltext Access 12 Pages 2008
Closing the door on flaviviruses: Entry as a target for antiviral drug design Fulltext Access 12 Pages 2008
Inhibition of human parainfluenza virus type 3 infection by novel small molecules Fulltext Access 12 Pages 2008
Development and validation of the patient trust in community pharmacists (TRUST-Ph) scale: Results from a study conducted in Thailand Fulltext Access 12 Pages 2008
Medical Expenditure Panel Survey: A valuable database for studying racial and ethnic disparities in prescription drug use Fulltext Access 12 Pages 2008
Patients' views on the UK policy of prescription charges-Insights from qualitative interviews Fulltext Access 12 Pages 2008
Comparing 4 classification systems for drug-related problems: Processes and functions Fulltext Access 12 Pages 2008
Protective effects of Angelica sinensis extract on amyloid β-peptide-induced neurotoxicity Fulltext Access 12 Pages 2008
Correlation between PAMPA permeability and cellular activities of hepatitis C virus protease inhibitors Fulltext Access 12 Pages 2008
Two single-center, double-blind, randomized, placebo-controlled, phase i studies to investigate the tolerability and pharmacokinetics of ch-1504, an antifolate, in healthy male subjects Fulltext Access 12 Pages 2008
Effects of fluticasone propionate/salmeterol combination on asthma-related health care resource utilization and costs and adherence in children and adults with asthma Fulltext Access 12 Pages 2008
Antihypertensive efficacy and tolerability of irbesartan/hydrochlorothiazide in hypertensive patients stratified by body mass index and type 2 diabetes mellitus status: A post hoc subgroup analysis of the Irbesartan/HCTZ Blood Pressure Reductions in Diver Fulltext Access 12 Pages 2008
Pharmacokinetics of 8-hour intravenous infusion of NXY-059: A phase I, randomized, double-blind (within dose panels), placebo-controlled study in healthy Chinese volunteers Fulltext Access 12 Pages 2008
Effect of flavonoids on rat splenocytes, a structure–activity relationship study Fulltext Access 12 Pages 2008
Mutational study of the “catalytic tetrad” of DNA topoisomerase IB from the hemoflagellate Leishmania donovani: Role of Asp-353 and Asn-221 in camptothecin resistance Fulltext Access 12 Pages 2008
Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84) Fulltext Access 12 Pages 2008
KRIBB3, a novel microtubule inhibitor, induces mitotic arrest and apoptosis in human cancer cells Fulltext Access 12 Pages 2008
Pharmacokinetic and safety profile of rupatadine when coadministered with azithromycin at steady-state levels: a randomized, open-label, two-way, crossover, Phase I study Fulltext Access 12 Pages 2008
Pleiotropic effects of selective CDK inhibitors on human normal and cancer cells Fulltext Access 12 Pages 2008
Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells Fulltext Access 12 Pages 2008
Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes Fulltext Access 12 Pages 2008
Deoxyelephantopin inhibits cancer cell proliferation and functions as a selective partial agonist against PPARγ Fulltext Access 12 Pages 2008
Release of arachidonic acid induced by tumor necrosis factor-α in the presence of caspase inhibition: Evidence for a cytosolic phospholipase A2α-independent pathway Fulltext Access 12 Pages 2008
Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines Fulltext Access 12 Pages 2008
Differential regulation of cell death in head and neck cell carcinoma through alteration of cholesterol levels in lipid rafts microdomains Fulltext Access 12 Pages 2008
Biochemical mechanisms underlying the pro-apoptotic activity of 7,8-dihydroxy-4-methylcoumarin in human leukemic cells Fulltext Access 12 Pages 2008
N-Alkoxy derivatization of indole-3-carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells Fulltext Access 12 Pages 2008
Antitumor effect of the angiogenesis inhibitor bevacizumab is dependent on susceptibility of tumors to hypoxia-induced apoptosis Fulltext Access 12 Pages 2008