Modulation of neurotransmitter release by P2X and P2Y receptors in the rat spinal cord Fulltext Access 12 Pages 2008
MGM-9 [(E)-methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine: A novel dual-acting μ- and κ-opioid agonist with potent a Fulltext Access 12 Pages 2008
Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage Fulltext Access 12 Pages 2008
Propofol enhances both tonic and phasic inhibitory currents in second-order neurons of the solitary tract nucleus (NTS) Fulltext Access 12 Pages 2008
The number of granule cells in rat hippocampus is reduced after chronic mild stress and re-established after chronic escitalopram treatment Fulltext Access 12 Pages 2008
Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1β administration Fulltext Access 12 Pages 2008
Antipsychotics increase vesicular glutamate transporter 2 (VGLUT2) expression in thalamolimbic pathways Fulltext Access 12 Pages 2008
Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity Fulltext Access 12 Pages 2008
Serotonin transporter transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs) Fulltext Access 12 Pages 2008
Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas Fulltext Access 12 Pages 2008
mGlu1α receptors are co-expressed with CB1 receptors in a subset of interneurons in the CA1 region of organotypic hippocampal slice cultures and adult rat brain Fulltext Access 12 Pages 2008
Effects of aripiprazole/OPC-14597 on motor activity, pharmacological models of psychosis, and brain activity in rats Fulltext Access 12 Pages 2008
Impaired synaptogenesis and long-term modulation of behavior following postnatal elevation of GABA levels in mice Fulltext Access 12 Pages 2008
Extending the analysis of nicotinic receptor antagonists with the study of α6 nicotinic receptor subunit chimeras Fulltext Access 12 Pages 2008
Calcium/calmodulin-dependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein Fulltext Access 12 Pages 2008
Several major antiepileptic drugs are substrates for human P-glycoprotein Fulltext Access 12 Pages 2008
Organic blockers escape from trapping in the AMPA receptor channels by leaking into the cytoplasm Fulltext Access 12 Pages 2008
Efficacy of the Injectable Calcium Phosphate Ceramics Suspensions Containing Magnesium, Zinc and Fluoride on the Bone Mineral Deficiency in Ovariectomized Rats Fulltext Access 12 Pages 2008
Drug–polymer interaction and its significance on the physical stability of nifedipine amorphous dispersion in microparticles of an ammonio methacrylate copolymer and ethylcellulose binary blend Fulltext Access 12 Pages 2008
On the Volume of Distribution at Steady State and Its Relationship With Two‐Compartmental Models Fulltext Access 12 Pages 2008
Use of hydrodynamic flow focusing for the generation of biodegradable camptothecinâloaded polymer microspheres Fulltext Access 12 Pages 2008
Cospray-dried unfractionated heparin with L-leucine as a dry powder inhaler mucolytic for cystic fibrosis therapy Fulltext Access 12 Pages 2008
Using a Modified Shepards Method for Optimization of a Nanoparticulate Cyclosporine A Formulation Prepared by a Static Mixer Technique Fulltext Access 12 Pages 2008
Allosteric kinetics of human carboxylesterase 1: Species differences and interindividual variability Fulltext Access 12 Pages 2008
Characterisation of novel defective thiopurine S-methyltransferase allelic variants Fulltext Access 12 Pages 2008
Relative contribution of rat cytochrome P450 isoforms to the metabolism of caffeine: The pathway and concentration dependence Fulltext Access 12 Pages 2008
Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides Fulltext Access 12 Pages 2008
The high-affinity immunoglobulin E receptor (FcÉRI) regulates mitochondrial calcium uptake and a dihydropyridine receptor-mediated calcium influx in mast cells: Role of the FcÉRIβ chain immunoreceptor tyrosine-based activation motif Fulltext Access 12 Pages 2008
Effects of adolescent nicotine and SR 147778 (Surinabant) administration on food intake, somatic growth and metabolic parameters in rats Fulltext Access 12 Pages 2008
The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition Fulltext Access 12 Pages 2008
Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others Fulltext Access 12 Pages 2008
Enforced expression of the tumor suppressor p53 renders human leukemia cells (U937) more sensitive to 1-[β-d-arabinofuranosyl]cytosine (ara-C)-induced apoptosis Fulltext Access 12 Pages 2008
An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies Fulltext Access 12 Pages 2008
Antibacterial and anti-atrophic effects of a highly soluble, acid stable UDCA formula in Helicobacter pylori-induced gastritis Fulltext Access 12 Pages 2008
Alterations in S-adenosylhomocysteine metabolism decrease O6-methylguanine DNA methyltransferase gene expression without affecting promoter methylation Fulltext Access 12 Pages 2008
The cytotoxicity of a Grb2-SH3 inhibitor in Bcr-Abl positive K562 cells Fulltext Access 12 Pages 2008
PLGA nanospheres for the ocular delivery of flurbiprofen: Drug release and interactions Fulltext Access 12 Pages 2008
In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: A comparison with human liver microsomes Fulltext Access 12 Pages 2008
Contribution of α4β1 integrin to the antiallergic effect of levocabastine Fulltext Access 12 Pages 2008
The profile of immune modulation by cannabidiol (CBD) involves deregulation of nuclear factor of activated T cells (NFAT) Fulltext Access 12 Pages 2008
Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice Fulltext Access 12 Pages 2008
CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-κB activation Fulltext Access 12 Pages 2008
Identification of the functional vitamin D response elements in the human MDR1 gene Fulltext Access 12 Pages 2008
Direct enhancement of hippocampal dopamine or serotonin levels as a pharmacodynamic measure of combined antidepressant–anticonvulsant action Fulltext Access 12 Pages 2008
Characterization of aconitine-induced block of delayed rectifier K+ current in differentiated NG108-15 neuronal cells Fulltext Access 12 Pages 2008
Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade Fulltext Access 12 Pages 2008
Depolarisation and suppression of burst firing activity in the mouse subthalamic nucleus by dopamine D1/D5 receptor activation of a cyclic-nucleotide gated non-specific cation conductance Fulltext Access 12 Pages 2008
The immobility produced by intermittent swim stress is not mediated by serotonin Fulltext Access 12 Pages 2008
Tumor necrosis factor receptor-associated death domain mediated neuronal death contributes to the glial activation and subsequent neuroinflammation in Japanese encephalitis Fulltext Access 12 Pages 2008
Stress and rodent models of drug addiction: role of VTA–accumbens–PFC–amygdala circuit Fulltext Access 12 Pages 2008
Targeted imaging: an important biomarker for understanding disease progression in the era of personalized medicine Fulltext Access 12 Pages 2008
Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia Fulltext Access 12 Pages 2008
Interaction between cannabinoid compounds and diazepam on anxiety-like behaviour of mice Fulltext Access 12 Pages 2008
Protective effect of Curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain Fulltext Access 12 Pages 2008
In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity Fulltext Access 12 Pages 2008
Assessing the relationship between latent inhibition and the partial reinforcement extinction effect in autoshaping with rats Fulltext Access 12 Pages 2008
Tuning adenosine A1 and A2A receptors activation mediates l-citrulline-induced inhibition of [3H]-acetylcholine release depending on nerve stimulation pattern Fulltext Access 12 Pages 2008
Withdrawal from acute morphine dependence is accompanied by increased anxiety-like behavior in the elevated plus maze Fulltext Access 12 Pages 2008
Periadolescent male but not female rats have higher motor activity in response to morphine than do adult rats Fulltext Access 12 Pages 2008
Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain Fulltext Access 12 Pages 2008
Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: Contrast with haloperidol and chlordiazepoxide Fulltext Access 12 Pages 2008
Functional up-regulation of P2X3 receptors in the chronically compressed dorsal root ganglion Fulltext Access 12 Pages 2008
Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn Fulltext Access 12 Pages 2008
Responses of algesic and metabolic substances to 8Â h of repetitive manual work in myalgic human trapezius muscle Fulltext Access 12 Pages 2008
Randomised controlled trials of selective serotonin reuptake inhibitors in treating depression in children and adolescents: A systematic review and meta-analysis Fulltext Access 12 Pages 2008
Region-specific involvement of AMPA/Kainate receptors in Fos protein expression induced by cocaine-conditioned cues Fulltext Access 12 Pages 2008
Pre-training administration of tianeptine, but not propranolol, protects hippocampus-dependent memory from being impaired by predator stress Fulltext Access 12 Pages 2008
Cannabinoid and opioid modulation of social play behavior in adolescent rats: Differential behavioral mechanisms Fulltext Access 12 Pages 2008
Degradation of paclitaxel and related compounds in aqueous solutions I: Epimerization Fulltext Access 12 Pages 2008
Correlation of Annealing with Chemical Stability in Lyophilized Pharmaceutical Glasses Fulltext Access 12 Pages 2008
Mechanistic Study of Electroosmotic Transport Across Hydrated Nail Plates: Effects of pH and Ionic Strength Fulltext Access 12 Pages 2008
Process Analytical Technology: Nondestructive Evaluation of Cyclosporine A and Phospholipid Solid Dispersions by Near Infrared Spectroscopy and Imaging Fulltext Access 12 Pages 2008
Drug Release Phenomena Within a Hydrophobic Starch Acetate Matrix: FTIR Mapping of Tablets After In Vitro Dissolution Testing Fulltext Access 12 Pages 2008
Design and Characterization of a New Miniaturized Rotating Disk Equipment for In Vitro Dissolution Rate Studies Fulltext Access 12 Pages 2008
Lateral and Rotational Mobility of Some Drug Molecules in a Poly(Ethylene Glycol) Diacrylate Hydrogel and the Effect of Drug-Cyclodextrin Complexation Fulltext Access 12 Pages 2008
Calorimetric Relaxation and the Glass-Liquid Temperature Range of Acetaminophen-Nifedipine Alloys Fulltext Access 12 Pages 2008
Effect of Nonsteroidal Anti-Inflammatory Drugs on the Cellular Membrane Fluidity Fulltext Access 12 Pages 2008
Enhanced Efficiency of Thermally Targeted Taxanes Delivery in a Human Xenograft Model of Gastric Cancer Fulltext Access 12 Pages 2008
Topical Corticosteroids, Structure-Activity and the Glucocorticoid Receptor: Discovery and Development-A Process of ''Planned Serendipity'' Fulltext Access 12 Pages 2008
Wet granulation as innovative and fast method to prepare controlled release granules based on an ionâexchange resin Fulltext Access 12 Pages 2008
Characteristics of hydrogen bond formation between sugar and polymer in freezeâdried mixtures under different rehumidification conditions and its impact on the glass transition temperature Fulltext Access 12 Pages 2008
Repeated low dose of phencyclidine administration impairs spatial learning in mice: Blockade by clozapine but not by haloperidol Fulltext Access 12 Pages 2008
Solubilization of hydrophobic drugs by methoxy poly(ethylene glycol)âblockâpolycaprolactone diblock copolymer micelles: Theoretical and experimental data and correlations Fulltext Access 12 Pages 2008
Quality by Design, Part I: Application of NIR Spectroscopy to Monitor Tablet Manufacturing Process Fulltext Access 12 Pages 2008
Correlation Between Molecular Mobility and Crystal Growth of Amorphous Phenobarbital and Phenobarbital with Polyvinylpyrrolidone and Lâproline Fulltext Access 12 Pages 2008
Passive Transfer of Polyethylene Glycol to Liposomal-Recombinant Human FVIII Enhances its Efficacy in a Murine Model for Hemophilia A Fulltext Access 12 Pages 2008
Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Pyrazinamide** Fulltext Access 12 Pages 2008
Effect of Anesthetic Structure on Inhalation Anesthesia: Implications for the Mechanism Fulltext Access 12 Pages 2008
Modifications in Low-Density Lipoprotein Receptor Expression Affects Cyclosporin A Cellular Uptake and Cytotoxicity Fulltext Access 12 Pages 2008
Combination Particles Containing Salmeterol Xinafoate and Fluticasone Propionate: Formulation and Aerodynamic Assessment Fulltext Access 12 Pages 2008
Glutamate release and synapsin-I phosphorylation induced by P2X7 receptors activation in cerebellar granule neurons Fulltext Access 12 Pages 2008
In vitro and in vivo evidences that antioxidant action contributes to the neuroprotective effects of the neuronal nitric oxide synthase and monoamine oxidase-B inhibitor, 7-nitroindazole Fulltext Access 12 Pages 2008