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Daneshyari Pharmacology Journas Latest Articles

Pharmacology Research Articles

Behavioral effects of the β3 adrenoceptor agonist SR58611A: Is it the putative prototype of a new class of antidepressant/anxiolytic drugs?
Fulltext Access 9 Pages 2007
Effect of protocatechualdehyde on receptor for advanced glycation end products and TGF-β1 expression in human lens epithelial cells cultured under diabetic conditions and on lens opacity in streptozotocin-diabetic rats
Fulltext Access 9 Pages 2007
Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs: Flufenamic acid and its 5-chloro-derivative directly interact with a recombinant human myeloperoxidase to inhibit the synthesis of hypochlorous acid
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The serotonin reuptake inhibitor citalopram does not affect colonic sensitivity or compliance in rats
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Neuroprotection in focal cerebral ischemia owing to delayed treatment with melanocortins
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β2 and β3-adrenoceptor inhibition of α1-adrenoceptor-stimulated Ca2+ elevation in human cultured prostatic stromal cells
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Phosphodiesterase 4 inhibitors, rolipram and diazepam block the adaptive changes observed during morphine withdrawal in the heart
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Comparison of vascular relaxation, lipolysis and glucose uptake by peroxisome proliferator-activated receptor-γ activation in + db/+ m and + db/+ db mice
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Antioxidant potential of fluoxetine in comparison to Curcuma longa in restraint-stressed rats
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Effects of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in a model of intestinal reperfusion injury in mice
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Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models
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TNF-α and IL-1β mediate inflammatory hypernociception in mice triggered by B1 but not B2 kinin receptor
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Characterization of SN-6, a novel Na+/Ca2+ exchange inhibitor in guinea pig cardiac ventricular myocytes
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Anti-inflammatory effects of compounds alpha-humulene and (−)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea
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Nicotinic and dopamine D2 receptors mediate nicotine-induced changes in ventral tegmental area neurotensin system
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Dopamine release in the nucleus accumbens (shell) of two lines of rats selectively bred to prefer or avoid ethanol
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Subcutaneous, intrathecal and periaqueductal grey administration of asimadoline and ICI-204448 reduces tactile allodynia in the rat
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Alpha 1-adrenoceptor agonists protect against stress-induced death of neural progenitor cells
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Dysregulation of the endogenous cannabinoid system in adult rats prenatally treated with the cannabinoid agonist WIN 55,212-2
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Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model
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Comparative study of the effects of betamethasone butyrate propionate, vitamin D3 derivatives, and cyclosporine on human lymphocyte-proliferation stimulated with a hemolytic streptococci-derived superantigen
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Cytoprotective effect of bis(1-oxy-2-pyridinethiolato)oxovanadiun(IV) on myocardial ischemia/reperfusion injury elicits inhibition of Fas ligand and Bim expression and elevation of FLIP expression
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Low dose combination of morphine and Δ9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors
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Pre-treatment and post-treatment with α-tocopherol attenuates hippocampal neuronal damage in experimental cerebral hypoperfusion
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Δ5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARα, in THP-1 cells
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Inhibition of the α9α10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-d-aspartate receptors
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Effect of diadenosine polyphosphates in achondroplasic chondrocytes: Inhibitory effect of Ap4A on FGF9 induced MAPK cascade
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Allosteric approaches to the targeting of G-protein-coupled receptors for novel drug discovery: A critical assessment
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Calmodulin potentiates Gβγ activation of phospholipase C-β3
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Glutamate-stimulated peroxynitrite production in a brain-derived endothelial cell line is dependent on N-methyl-d-aspartate (NMDA) receptor activation
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Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin
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Upregulation of sodium-dependent vitamin C transporter 2 expression in adrenals increases norepinephrine production and aggravates hyperlipidemia in mice with streptozotocin-induced diabetes
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Rosmarinic acid induces melanogenesis through protein kinase A activation signaling
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Vitamin B12b increases the cytotoxicity of short-time exposure to ascorbic acid, inducing oxidative burst and iron-dependent DNA damage
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Intracellular calcium stores in β-escin skinned rat and guinea-pig bladders
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Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: Acute and subchronic studies in rats
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Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes
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Is digitalis compound-induced cardiotoxicity, mediated through guinea-pig cardiomyocytes apoptosis?
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Mechanisms of HDAC inhibitor-induced thrombocytopenia
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Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: Nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1
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Resveratrol enhances insulin secretion by blocking KATP and KV channels of beta cells
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Phospholipase D-dependent and -independent p38MAPK activation pathways are required for superoxide production and chemotactic induction, respectively, in rat neutrophils stimulated by fMLP
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Combination of VEGF165/Angiopoietin-1 gene and endothelial progenitor cells for therapeutic neovascularization
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Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis
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Involvement of nitric oxide (NO) signaling pathway in the antidepressant action of bupropion, a dopamine reuptake inhibitor
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Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy
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Serotonin 5-HT2C receptor homodimerization is not regulated by agonist or inverse agonist treatment
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Effect of conjugated linoleic acid on bone formation and rheumatoid arthritis
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Importance of intracellular Angiotensin II in vascular smooth muscle cell apoptosis: Inhibition by the Angiotensin AT1 receptor antagonist irbesartan
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Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats
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Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells
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Geldanamycin induces G2 arrest in U87MG glioblastoma cells through downregulation of Cdc2 and cyclin B1
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New paradigms in signal transduction
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Promotion of DNA strand breaks, interstrand cross-links and apoptotic cell death in A2780 human ovarian cancer cells by transplatinum planar amine complexes
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Fumonisin B1 exposure and its selective effect on porcine jejunal segment: Sphingolipids, glycolipids and trans-epithelial passage disturbance
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The determination and correlation of molecular and cellular equilibrium Kd and kinetic koff values for small molecule allosteric antagonists of LFA-1
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Calcium channel antagonists: Clinical uses—Past, present and future
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Irreversible binding of a novel phenylisothiocyanate tropane analog to monoamine transporters in rat brain
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Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells
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De novo ceramide biosynthesis is associated with resveratrol-induced inhibition of ornithine decarboxylase activity
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β-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages
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Apoptosis induction of 2′-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells
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Antagonism of the insulinotropic action of first generation imidazolines by openers of KATP channels
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Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein
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Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients
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Oral administration of phenolic antidiarrheic ingredients prevents ovariectomy-induced bone loss
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Efficacy of a comfrey root (Symphyti offic. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: Results of a double-blind, randomised, bicenter, placebo-controlled trial
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Screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance
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Steroid-sparing effect of wormwood (Artemisia absinthium) in Crohn's disease: A double-blind placebo-controlled study
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Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants
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Effect of Stemona curtisii root extract on P-glycoprotein and MRP-1 function in multidrug-resistant cancer cells
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Ginseng modifies the diabetic phenotype and genes associated with diabetes in the male ZDF rat
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Bioavailability of the phenolic compounds of the fruits (drupes) of Olea europaea (olives): Impact on plasma antioxidant status in humans
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Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation
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In vitro evaluation of antibacterial and immunomodulatory activities of Pelargonium reniforme, Pelargonium sidoides and the related herbal drug preparation EPs® 7630
Fulltext Access 9 Pages 2007
AC260584 (4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one), a selective muscarinic M1 receptor agonist, increases acetylcholine and dopamine release in rat medial prefrontal cortex and hippocampus
Fulltext Access 9 Pages 2007
ME3738 protects against lithocholic acid-induced hepatotoxicity, which is associated with enhancement of biliary bile acid and cholesterol output
Fulltext Access 9 Pages 2007
Differences in agonist/antagonist properties at human dopamine D2 receptors between aripiprazole, bifeprunox and SDZ 208-912
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Isokotomolide A, a new butanolide extracted from the leaves of Cinnamomum kotoense, arrests cell cycle progression and induces apoptosis through the induction of p53/p21 and the initiation of mitochondrial system in human non-small cell lung cancer A549 c
Fulltext Access 9 Pages 2007
EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by α2A-adrenoreceptor in intestinal epithelial cells: A role in wound healing
Fulltext Access 9 Pages 2007
The endocannabinoids anandamide and 2-arachidonoylglycerol inhibit cholinergic contractility in the human colon
Fulltext Access 9 Pages 2007
In vivo adenosine A2B receptor desensitization in guinea-pig airway smooth muscle: Implications for asthma
Fulltext Access 9 Pages 2007
A gender-independent proarrhythmic action of 17β-estradiol in anaesthetized rabbits
Fulltext Access 9 Pages 2007
Dopamine D1 and D2 receptor agonism enhances antinociception mediated by the serotonin and noradrenaline reuptake inhibitor duloxetine in the rat formalin test
Fulltext Access 9 Pages 2007
Enantio-selective effects of clenbuterol in cultured neurons and astrocytes, and in a mouse model of cerebral ischemia
Fulltext Access 9 Pages 2007
Genistein-induced neuronal apoptosis and G2/M cell cycle arrest is associated with MDC1 up-regulation and PLK1 down-regulation
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Cholinergic drugs affect novel object recognition in rats: Relation with hippocampal EEG?
Fulltext Access 9 Pages 2007
N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: A comparison with donepezil and rivastigmine
Fulltext Access 9 Pages 2007
Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme, traditional and phytomedicinal sources of the herbal medicine Umckaloabo®
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Methamphetamine-induced hyperthermia and lethal toxicity: Role of the dopamine and serotonin transporters
Fulltext Access 9 Pages 2007
Mechanisms of prodigiosin cytotoxicity in human neuroblastoma cell lines
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Inhibition of cyclooxygenase-2 down-regulates osteoclast and osteoblast differentiation and favours adipocyte formation in vitro
Fulltext Access 9 Pages 2007
Pharmacokinetic significance of luminal multidrug and toxin extrusion 1 in chronic renal failure rats
Fulltext Access 9 Pages 2007
Mechanism of dopamine mediated inhibition of neuropeptide Y release from pheochromocytoma cells (PC12 cells)
Fulltext Access 9 Pages 2007
Improved endothelial function and reduced platelet activation by chronic HMG-CoA-reductase inhibition with rosuvastatin in rats with streptozotocin-induced diabetes mellitus
Fulltext Access 9 Pages 2007
Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells
Fulltext Access 9 Pages 2007
Cancer chemopreventive properties of orally bioavailable flavonoids—Methylated versus unmethylated flavones
Fulltext Access 9 Pages 2007
Glucuronidation of fenamates: Kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7
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Glutathione depletion and recovery after acute ethanol administration in the aging mouse
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Inhibition of ADP-induced platelet adhesion to immobilised fibrinogen by nitric oxide: Evidence for cGMP-independent mechanisms
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