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Pharmacology Research Articles

Selective antagonist at D3 receptors, but not non-selective partial agonists, influences the expression of cocaine-induced conditioned place preference in free-feeding rats
Fulltext Access 8 Pages 2005
Role of peripheral group I and II metabotropic glutamate receptors in IL-1β-induced mechanical allodynia in the orofacial area of conscious rats
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Prolonged rhythmic gum chewing suppresses nociceptive response via serotonergic descending inhibitory pathway in humans
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Different profiles of buprenorphine-induced analgesia and antihyperalgesia in a human pain model
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Peripheral inflammation induces up-regulation of TRPV2 expression in rat DRG
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The economic impact of chronic pain in adolescence: Methodological considerations and a preliminary costs-of-illness study
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The role of threat-expectancy in acute pain: effects on attentional bias, coping strategy effectiveness and response to pain
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Excitatory amino acid concentrations increase in the spinal cord dorsal horn after repeated intramuscular injection of acidic saline
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Effect of metabotropic glutamate receptor agonists and signal transduction modulators on feeding by a caterpillar
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A comprehensive assessment of the safety of intravenous methamphetamine administration during treatment with selegiline
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Multilevel somatosensory system disinhibition in children with migraine
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Effects of nicotine and epibatidine on locomotor activity and conditioned place preference in rats
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Behavioral sensitization and voluntary ethanol drinking in alcohol-preferring AA rats exposed to different regimens of morphine treatment
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Assessment of the contributions of Na+ channel inhibition and general peripheral action in cocaine-induced conditioned taste aversion
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Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist
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Mechanisms underlying anorexia after microinjection of bombesin into the lateral cerebroventricle
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Naltrexone-induced conditioned place aversion following a single dose of morphine in the rat
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Dyskinesias in normal squirrel monkeys induced by nomifensine and levodopa
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Neuropharmacological evaluation of diethylether extract and xanthones of Gentiana kochiana
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mGlu and NMDA receptor contributions to capsaicin-induced thermal and mechanical hypersensitivity
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Levetiracetam selectively potentiates the acute neurotoxic effects of topiramate and carbamazepine in the rotarod test in mice
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Stratégie anti-douleur en pratique quotidienne
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Modèles cognitifs et comportementaux dans la compréhension du phénomène de douleur chronique
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Les antalgiques de palier 2 en pratique
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A survey of postoperative pain management in fourteen hospitals in the UK
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Inhibition of rat liver CYP2D in vitro and after 1-day and long-term exposure to neuroleptics in vivo-possible involvement of different mechanisms
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Chlorpromazine and loxapine reduce interleukin-1β and interleukin-2 release by rat mixed glial and microglial cell cultures
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The epidemiology of generalized anxiety disorder in Europe
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Dissociation between the locomotor and anxiolytic effects of acetaldehyde in the elevated plus-maze: Evidence that acetaldehyde is not involved in the anxiolytic effects of ethanol in mice
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Nicotine increases microdialysate brain amino acid concentrations and induces conditioned place preference
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Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats
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Clozapine improves working memory updating in schizophrenia
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Pharmacological dissociation of moderate and high contextual fear as assessed by freezing behavior and fear-potentiated startle
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Potential antidepressant properties of IDN 5491 (hyperforin-trimethoxybenzoate), a semisynthetic ester of hyperforin
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Chronic administration of the SSRI fluvoxamine markedly and selectively reduces the sensitivity of cortical serotonergic neurons to footshock stress
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Meal patterns in female rats during and after intermittent nicotine administration
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Alterations in GABAergic function following forced swimming stress
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Neurochemical, pharmacokinetic, and behavioral effects of the novel selective serotonin reuptake inhibitor BMS-505130
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Meal patterns and body weight after nicotine in male rats as a function of chow or high-fat diet
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Biopharmaceutical Considerations on Antihistamine Effects of Topically Administered Emedastine
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Contribution of ROCK in Contraction of Trabecular Meshwork: Proposed Mechanism for Regulating Aqueous Outflow in Monkey and Human Eyes
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Oral heparin delivery: Design and in vivo evaluation of a stomach-targeted mucoadhesive delivery system
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Preparation of polymeric nanocapsules containing octyl methoxycinnamate by the emulsification-diffusion technique: Penetration across the stratum corneum
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Erosion of microbicide formulation coating layers: Effects of contact and shearing with vaginal fluid or semen
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Influence of macromolecular crowding upon the stability and state of association of proteins: Predictions and observations
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Role of Organic Anion Transporting Polypeptide 2 in Pharmacokinetics of Digoxin and β-Methyldigoxin in Rats
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Application of Ultrasonic Shear Rheometer to Characterize Rheological Properties of High Protein Concentration Solutions at Microliter Volume
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Hepatobiliary Disposition of Liposomal Amphotericin B in the Isolated Perfused Rat Liver
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Simple Strategies for Reducing Sample Loads in In Vitro Metabolic Stability High-Throughput Screening Experiments: A Comparison between Traditional, Two-Time-Point and Pooled Sample Analyses
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Transdermal Iontophoretic Delivery of Triptorelin in Vitro
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Nuclear magnetic resonance investigation of the interaction of water vapor with sildenafil citrate in the solid state
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Methyl esters of N‐(dicyclohexyl)acetyl‐piperidine‐4‐(benzylidene‐4‐carboxylic acids) as drugs and prodrugs: A new strategy for dual inhibition of 5α‐reductase type 1 and type 2
Fulltext Access 8 Pages 2005
Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction
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Cationic Analog of Deoxycholate as an Oral Delivery Carrier for Ceftriaxone
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Formation and characterization of porous indomethacin-PVP coprecipitates prepared using solvent-free supercritical fluid processing
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Quantifying Errors in Tableting Data Analysis Using the Ryshkewitch Equation Due to Inaccurate True Density
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Solubility and Prediction of the Heat of Solution of Sodium Naproxen in Aqueous Solutions
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Effect of Chloride ion on Dissolution of Different Salt Forms of Haloperidol, a Model Basic Drug
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Ebselen attenuates haloperidol-induced orofacial dyskinesia and oxidative stress in rat brain
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Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats
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Nicotine pretreatment diminished physostigmine-induced tremor in rats
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Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells
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Adenosine receptors co-operate with NMDA preconditioning to protect cerebellar granule cells against glutamate neurotoxicity
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Neuroprotective effect of zVAD against the neurotoxin 3-nitropropionic acid involves inhibition of calpain
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The oxidative neurotoxicity of clioquinol
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High fat diet increases the incidence of orofacial dyskinesia and oxidative stress in specific brain regions of rats
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Involvement of sigma (σ) receptors in the acute actions of methamphetamine: Receptor binding and behavioral studies
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Cognitive enhancement in aged rats after chronic administration of Equisetum arvense L. with demonstrated antioxidant properties in vitro
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Ambroxol, a Nav1.8-preferring Na+ channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain
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Δ9-Tetrahydrocannabinol-induced desensitization of cannabinoid-mediated inhibition of synaptic transmission between hippocampal neurons in culture
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Mefloquine inhibits cholinesterases at the mouse neuromuscular junction
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Agonists of peroxisome proliferator-activated receptor-γ attenuate the Aβ-mediated impairment of LTP in the hippocampus in vitro
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In silico strategies for modeling membrane transporter function
Fulltext Access 9 Pages 2005
Delivery options for contraceptives
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Not all viruses are bad guys: the case for reovirus in cancer therapy
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Peroxidases: a role in the metabolism and side effects of drugs
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Staphylococcus aureus: the search for novel targets
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In vivo behavioral effects of stable, receptor-selective neurotensin[8-13] analogues that cross the blood-brain barrier
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Serotonin 5-HT2A but not 5-HT2C receptor antagonism reduces hyperlocomotor activity induced in dopamine-depleted rats by striatal administration of the D1 agonist SKF 82958
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5-HT1A receptor agonists modify epileptic seizures in three experimental models in rats
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Paraventricular hypothalamic CB1 cannabinoid receptors are involved in the feeding stimulatory effects of Δ9-tetrahydrocannabinol
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Activation of GABAA receptors by taurine and muscimol blocks the neurotoxicity of β-amyloid in rat hippocampal and cortical neurons
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Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: Sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla
Fulltext Access 9 Pages 2005
Postsynaptic actions of substance P on rat periaqueductal grey neurons in vitro
Fulltext Access 9 Pages 2005
Time course of opioid and cannabinoid gene transcription alterations induced by repeated administration with fluoxetine in the rat brain
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Endocannabinoids restrict hippocampal long-term potentiation via CB1
Fulltext Access 9 Pages 2005
Effects of emodin on synaptic transmission in rat hippocampal CA1 pyramidal neurons in vitro
Fulltext Access 9 Pages 2005
Pro-VGF-derived peptides induce penile erection in male rats: Involvement of paraventricular nitric oxide
Fulltext Access 9 Pages 2005
Munc18-dependent regulation of synaptic vesicle exocytosis by syntaxin-1A in hippocampal neurons
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From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research
Fulltext Access 9 Pages 2005
Ascorbic acid inhibits ROS production, NF-κB activation and prevents ethanol-induced growth retardation and microencephaly
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Novel antipsychotic agents with 5-HT1A agonist properties: Role of 5-HT1A receptor activation in attenuation of catalepsy induction in rats
Fulltext Access 9 Pages 2005
Inhibitory effect of imipramine on the human corticotropin-releasing-hormone gene promoter activity operates through a PI3-K/AKT mediated pathway
Fulltext Access 9 Pages 2005
Naltrexone in the short-term decreases antiparkinsonian response to l-Dopa and in the long-term increases dyskinesias in drug-naïve parkinsonian monkeys
Fulltext Access 9 Pages 2005
Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8
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Rapid delivery of the dopamine transporter to the plasmalemmal membrane upon amphetamine stimulation
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Serotonin-transporter mediated efflux: A pharmacological analysis of amphetamines and non-amphetamines
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Therapies for rheumatoid arthritis: hope springs eternal
Fulltext Access 9 Pages 2005
Representativity of target families in the Protein Data Bank: impact for family-directed structure-based drug discovery
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Novel and emerging therapies for asthma
Fulltext Access 9 Pages 2005
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