Keynote review: Is declining innovation in the pharmaceutical industry a myth? Fulltext Access 9 Pages 2005
Disease models for elucidation of mechanisms and prediction of drug-induced proarrhythmia Fulltext Access 9 Pages 2005
Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased α2C-adrenoceptor co-expression and functional inhibition by clonidine Fulltext Access 9 Pages 2005
Intravenous dextromethorphan to human volunteers: relationship between pharmacokinetics and anti-hyperalgesic effect Fulltext Access 9 Pages 2005
Chronic spinal pain and physical-mental comorbidity in the United States: results from the national comorbidity survey replication Fulltext Access 9 Pages 2005
Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation Fulltext Access 9 Pages 2005
Spinal 5-HT1A receptors differentially influence nociceptive processing according to the nature of the noxious stimulus in rats: effect of WAY-100635 on the antinociceptive activities of paracetamol, venlafaxine and 5-HT Fulltext Access 9 Pages 2005
Sensory function and quality of life in patients with multiple sclerosis and pain Fulltext Access 9 Pages 2005
Acrolein-induced cell death in PC12 cells: Role of mitochondria-mediated oxidative stress Fulltext Access 9 Pages 2005
Potential role for nonesterified fatty acids in β-adrenoceptor-induced increases in brain tryptophan Fulltext Access 9 Pages 2005
Aβ(31-35) peptide induce apoptosis in PC 12 cells: Contrast with Aβ(25-35) peptide and examination of underlying mechanisms Fulltext Access 9 Pages 2005
Convulsant activity and neurochemical alterations induced by a fraction obtained from fruit Averrhoa carambola (Oxalidaceae: Geraniales) Fulltext Access 9 Pages 2005
Purine nucleoside-mediated protection of chemical hypoxia-induced neuronal injuries involves p42/44 MAPK activation Fulltext Access 9 Pages 2005
PC12 and HEL cell communication in a reconstituted synapse analyzed with mathematical modeling Fulltext Access 9 Pages 2005
Role of Bcl-2 family of proteins in mediating apoptotic death of PC12 cells exposed to oxygen and glucose deprivation Fulltext Access 9 Pages 2005
Differences in the neurotoxicity profile induced by ATP and ATPγS in cultured cerebellar granule neurons Fulltext Access 9 Pages 2005
Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced toxicity in cortical cultured neurons Fulltext Access 9 Pages 2005
Tricarboxylic acid cycle inhibition by Li+ in the human neuroblastoma SH-SY5Y cell line: A 13C NMR isotopomer analysis Fulltext Access 9 Pages 2005
Age effects on pain thresholds, temporal summation and spatial summation of heat and pressure pain Fulltext Access 9 Pages 2005
Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat Fulltext Access 9 Pages 2005
Characterization of cells with proliferative activity after a brain injury Fulltext Access 9 Pages 2005
Protein S100B release from rat brain slices during and after ischemia: Comparison with lactate dehydrogenase leakage Fulltext Access 9 Pages 2005
Increasing blood oxygen increases an index of 5-HT synthesis in human brain as measured using α-[11C]methyl-l-tryptophan and positron emission tomography Fulltext Access 9 Pages 2005
Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells Fulltext Access 9 Pages 2005
A longitudinal study on the predictive validity of the fear-avoidance model in low back pain Fulltext Access 9 Pages 2005
Residual complaints following lumbar disc surgery: prognostic indicators of outcome Fulltext Access 9 Pages 2005
Excitatory and modulatory effects of inflammatory cytokines and neurotrophins on mechanosensitive group IV muscle afferents in the rat Fulltext Access 9 Pages 2005
Characterization of morphine-induced hyperalgesia in male and female rats Fulltext Access 9 Pages 2005
Spinal CK2 regulates nociceptive signaling in models of inflammatory pain Fulltext Access 9 Pages 2005
Segmental noxious versus innocuous electrical stimulation for chronic pain relief and the effect of fading sensation during treatment Fulltext Access 9 Pages 2005
Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat Fulltext Access 9 Pages 2005
A rat model of unilateral hindpaw burn injury: Slowly developing rightwards shift of the morphine dose-response curve Fulltext Access 9 Pages 2005
Activity of masticatory muscles in subjects with different orofacial pain conditions Fulltext Access 9 Pages 2005
Spinal and local peripheral antiallodynic activity of Ro64-6198 in neuropathic pain in the rat Fulltext Access 9 Pages 2005
Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis Fulltext Access 9 Pages 2005
Molecular and behavioral changes in nociception in a novel rat model of chronic pancreatitis for the study of pain Fulltext Access 9 Pages 2005
Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica Fulltext Access 9 Pages 2005
Effects of intradermal foot and forearm capsaicin injections in normal and vulvodynia-afflicted women Fulltext Access 9 Pages 2005
Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice Fulltext Access 9 Pages 2005
Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels Fulltext Access 9 Pages 2005
Increased nerve growth factor after rat plantar incision contributes to guarding behavior and heat hyperalgesia Fulltext Access 9 Pages 2005
Enhanced antinociception by intracerebroventricularly administered orexin A in histamine H1 or H2 receptor gene knockout mice Fulltext Access 9 Pages 2005
Relationship of pain and symptoms to pubertal development in adolescents Fulltext Access 9 Pages 2005
Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls Fulltext Access 9 Pages 2005
A human experimental capsaicin model for trigeminal sensitization. Gender-specific differences Fulltext Access 9 Pages 2005
MRL/lpr mice have alterations in brain metabolism as shown with [1H-13C] NMR spectroscopy Fulltext Access 9 Pages 2005
The role of everyday emotion regulation on pain in hospitalized elderly: Insights from a prospective within-day assessment Fulltext Access 9 Pages 2005
Dynamic mechanical allodynia: On the relationship between temporo-spatial stimulus parameters and evoked pain in patients with peripheral neuropathy Fulltext Access 9 Pages 2005
The measurement of postoperative pain: A comparison of intensity scales in younger and older surgical patients Fulltext Access 9 Pages 2005
Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice Fulltext Access 9 Pages 2005
Neurophysiologic and quantitative sensory testing in the diagnosis of trigeminal neuropathy and neuropathic pain Fulltext Access 9 Pages 2005
Ambivalence over emotional expression in patients with gastrointestinal cancer and their caregivers: Associations with patient pain and quality of life Fulltext Access 9 Pages 2005
GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation Fulltext Access 9 Pages 2005
Intersession coping skill practice mediates the relationship between readiness for self-management treatment and goal accomplishment Fulltext Access 9 Pages 2005
Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat Fulltext Access 9 Pages 2005
Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats Fulltext Access 9 Pages 2005
Dose-dependent effects of morphine on experimentally induced cutaneous pain in healthy volunteers Fulltext Access 9 Pages 2005
Identification of subgroups of persons with chronic pain based on profiles on the pain stages of change questionnaire Fulltext Access 9 Pages 2005
Ammonia effects on pyruvate/lactate production in astrocytes-Interaction with glutamate Fulltext Access 9 Pages 2005
New metallothionein mRNAs in Gobio gobio reveal at least three gene duplication events in cyprinid metallothionein evolution Fulltext Access 9 Pages 2005
Antioxidant responses of the Mediterranean mussel, Mytilus galloprovincialis, to environmental variability of dissolved oxygen Fulltext Access 9 Pages 2005
cDNA cloning and expression pattern of pi-class glutathione S-transferase in the freshwater bivalves Unio tumidus and Corbicula fluminea Fulltext Access 9 Pages 2005
The development and preliminary validation of a brief measure of chronic pain impact for use in the general population Fulltext Access 9 Pages 2005
Lack of estrogen increases pain in the trigeminal formalin model: a behavioural and immunocytochemical study of transgenic ArKO mice Fulltext Access 9 Pages 2005
Inhibitors of serine/threonine protein phosphatases antagonize the antinociception induced by agonists of α2 adrenoceptors and GABAB but not κ-opioid receptors in the tail flick test in mice Fulltext Access 9 Pages 2005
Differential modulation of TMJ neurons in superficial laminae of trigeminal subnucleus caudalis/upper cervical cord junction region of male and cycling female rats by morphine Fulltext Access 9 Pages 2005