| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2019157 | Progress in Lipid Research | 2011 | 18 Pages |
Abstract
⺠Neural membranes contain several classes of glycerophospholipids (GPs), sphingolipids, and proteins. ⺠Enzymatic degradation of GPs produces two brain polyunsaturated fatty acids, arachidonic acid and docosahexaenoic acid. ⺠Intracellular lipid metabolism is perturbed in various cardiovascular and neurodegenerative diseases. ⺠GP metabolism is closely associated with pathways involved in the neurobiology of Alzheimer's Disease (AD).
Keywords
EPALPSTRPV1COX4-HNEAEACA1NSAIDBACE1AβNF-kBBcl-2ERKMARLPINOSPPAR2-AGLPCLPElysophosphatidylethanolamineAPPCB1NMDAN-methyl-d-aspartatecPLA2RPEPKCNMDAR2-arachidonoylglycerolFAAHmGluRCB2NFTGSK-3LPARetinoid X receptorrCBFPAFRPMNPLA2sPLA2RARRXR4-HHELC-ESI-MSEPOXMDAisofuranLiquid chromatography electrospray ionization mass spectrometryfatty acid amidohydrolasec-Jun N-terminal kinase/stress-activated protein kinaselong-chain fatty acyl-CoA synthetase4-HydroxyhexenalBDNFJNK/SAPKMAPKROSβ-AmyloidADAMendocannabinoidcyclooxygenasephospholipase A2mild cognitive impairmentArachidonic acidEicosapentaenoic aciddocosahexaenoic acidSecretory phospholipase A2lysophosphatidic acidLinoleic acidhydroxyeicosatetraenoic acidPolyunsaturated fatty acidsPolyunsaturated fatty acidPUFAendocannabinoidsADAPTretinal pigment epitheliumLOXisoprostaneIsopinterleukineicosanoidsBaxBADAlzheimer’s diseasea disintegrin and metalloproteasethromboxanelong term potentiationLTPtumor necrosis factor-αRegional cerebral blood flowDementiaNeurofibrillary tangleDocosanoidsCNSDHAResolvinDietBBBBlood–brain barriercentral nervous systemendoplasmic reticulumSenile plaquePlatelet activating factorNon-steroidal anti-inflammatory drugBrain-derived neurotrophic factorTNF-αNuclear factor-kappa Bphosphatidylinositolphosphatidylcholinephosphatidylethanolaminecytosolic phospholipase A2B-cell lymphoma 2LeukotrieneLysophosphatidylcholineLysophosphatidylserineLysophosphatidylinositollipoxygenaseslipoxinmalondialdehydeCerebrospinal fluidCSFMaresinBcl-2-associated death promoterPolymorphonuclear neutrophilsNeuroprostanenitric oxide synthasePAFHETEMCILipid mediatorsTransient receptor potential vanilloid 1Bcl-2-associated X proteinamyloid precursor proteinProtein kinase Cmitogen-activated protein kinaseprostaglandinextracellular signal-regulated kinaseglycerophospholipidglycerophospholipidsglycogen synthase kinase 3Reactive oxygen speciesRetinoic acid receptorperoxisome proliferator-activated receptorMetabotropic glutamate receptor
Related Topics
Life Sciences
Agricultural and Biological Sciences
Food Science
Authors
Vincenza Frisardi, Francesco Panza, Davide Seripa, Tahira Farooqui, Akhlaq A. Farooqui,