α-Tocopherol induces calnexin in renal tubular cells: Another protective mechanism against free radical-induced cellular damage Fulltext Access 11 Pages 2006
Role of threonine residues in the regulation of manganese-dependent arabidopsis serine/threonine/tyrosine protein kinase activity Fulltext Access 11 Pages 2006
The binding between p67 and eukaryotic initiation factor 2 plays important roles in the protection of eIF2α from phosphorylation by kinases Fulltext Access 11 Pages 2006
Streptomyces coelicolor oxidase (SCO2837p): A new free radical metalloenzyme secreted by Streptomyces coelicolor A3(2) Fulltext Access 11 Pages 2006
Evidence for the transglycosylation of complex type oligosaccharides of glycoproteins by endo-β-N-acetylglucosaminidase HS Fulltext Access 11 Pages 2006
Toward synthesis of the regular sequence of heparin: synthesis of two tetrasaccharide precursors Fulltext Access 11 Pages 2006
Conformations of methyl 2,5-di-O-acetyl-β-d-glucofuranosidurono-6,3-lactone and 1,2,5-tri-O-acetyl-β-d-glucofuranurono-6,3-lactone in the crystal structure and in solution Fulltext Access 11 Pages 2006
Physicochemical characterization of cellulose from perennial ryegrass leaves (Lolium perenne) Fulltext Access 11 Pages 2006
Folding and assembly pathways of co-chaperonin proteins 10: Origin of bacterial thermostability Fulltext Access 11 Pages 2006
Complete assignment of 1H and 13C NMR spectra of Gigartina skottsbergii λ-carrageenan using carrabiose oligosaccharides prepared by enzymatic hydrolysis Fulltext Access 11 Pages 2006
Low- and high-resolution nuclear magnetic resonance (NMR) characterisation of hyaluronan-based native and sulfated hydrogels Fulltext Access 11 Pages 2006
A novel oligoalginate lyase from abalone, Haliotis discus hannai, that releases disaccharide from alginate polymer in an exolytic manner Fulltext Access 11 Pages 2006
Studies on the chemistry of thienoanellated O,N- and S,N-containing heterocycles. Part 30: Synthesis and pharmacological properties of thieno[2,3-b][1,4]thiazines with potential vasopressin receptor antagonistic activity Fulltext Access 11 Pages 2006
Synthesis and characterization of selective dopamine D2 receptor antagonists Fulltext Access 11 Pages 2006
Constructing plasma protein binding model based on a combination of cluster analysis and 4D-fingerprint molecular similarity analyses Fulltext Access 11 Pages 2006
Novel 5-(2-hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2-thione derivatives: Promising anticancer agents Fulltext Access 11 Pages 2006
Synthesis, radiosynthesis and in vivo preliminary evaluation of [11C]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET Fulltext Access 11 Pages 2006
Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors Fulltext Access 11 Pages 2006
Building a successful structural motif into sialylmimetics—cyclohexenephosphonate monoesters as pseudo-sialosides with promising inhibitory properties Fulltext Access 11 Pages 2006
Free radicals in blood: Evolving concepts in the mechanism of ischemic heart disease Fulltext Access 11 Pages 2006
1,3-Dideoxynojirimycin-3-yl glycosides of β-(1â3)- and β-(1â6)-linked gluco-oligosaccharides Fulltext Access 11 Pages 2006
Acceptor-dependent regioselectivity of glycosynthase reactions by Streptomyces E383A β-glucosidase Fulltext Access 11 Pages 2006
Synthesis of globo- and isoglobotriosides bearing a cinnamoylphenyl tag as novel electrophilic thiol-specific carbohydrate reagents Fulltext Access 11 Pages 2006
Detection of dideoxyosone intermediates of glycation using a monoclonal antibody: Characterization of major epitope structures Fulltext Access 11 Pages 2006
Isolation of a latent polyphenol oxidase from loquat fruit (Eriobotrya japonica Lindl.): Kinetic characterization and comparison with the active form Fulltext Access 11 Pages 2006
Calcineurin dephosphorylates the C-terminal region of filamin in an important regulatory site: A possible mechanism for filamin mobilization and cell signaling Fulltext Access 11 Pages 2006
Myeloperoxidase-mediated oxidation of high-density lipoproteins: Fingerprints of newly recognized potential proatherogenic lipoproteins Fulltext Access 11 Pages 2006
Monitoring farnesol-induced toxicity in tobacco BY-2 cells with a fluorescent analog Fulltext Access 11 Pages 2006
c-Jun N-terminal kinase regulates CTP:phosphocholine cytidylyltransferase Fulltext Access 11 Pages 2006
Ceramides reduce CD36 cell surface expression and oxidised LDL uptake by monocytes and macrophages Fulltext Access 11 Pages 2006
Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses Fulltext Access 11 Pages 2006
A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo Fulltext Access 11 Pages 2006
Structural analogues of reactive intermediates as inhibitors of glucosamine-6-phosphate synthase and phosphoglucose isomerase Fulltext Access 11 Pages 2006
Inflammatory cytokines induce protein tyrosine nitration in rat astrocytes Fulltext Access 11 Pages 2006
The naturally occurring biflavonoid, ochnaflavone, inhibits LPS-induced iNOS expression, which is mediated by ERK1/2 via NF-κB regulation, in RAW264.7 cells Fulltext Access 11 Pages 2006
Hepatocyte nuclear factor-4α plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver Fulltext Access 11 Pages 2006
A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis Fulltext Access 11 Pages 2006
Fluoroalcohols induced unfolding of Succinylated Con A: Native like β-structure in partially folded intermediate and α-helix in molten globule like state Fulltext Access 11 Pages 2006
Biochemical characterization, cloning, and molecular modelling of chicken pancreatic lipase Fulltext Access 11 Pages 2006
Down-regulation of PPARγ2-induced adipogenesis by PEGylated conjugated linoleic acid as the pro-drug: Attenuation of lipid accumulation and reduction of apoptosis Fulltext Access 11 Pages 2006
Synthesis and in vitro antitumor evaluation of some indeno[1,2-c]pyrazol(in)es substituted with sulfonamide, sulfonylurea(-thiourea) pharmacophores, and some derived thiazole ring systems Fulltext Access 11 Pages 2006
Synthesis and conformational analysis of His-Phe-Arg-Trp-NH2 and analogues with antifungal properties Fulltext Access 11 Pages 2006
Amino- and glycoconjugates of pyrido[4,3,2-kl]acridine. Synthesis, antitumor activity, and DNA binding Fulltext Access 11 Pages 2006
Novel potent neuropeptide Y Y5 receptor antagonists: Synthesis and structure–activity relationships of phenylpiperazine derivatives Fulltext Access 11 Pages 2006
Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site Fulltext Access 11 Pages 2006
Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity Fulltext Access 11 Pages 2006
Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents Fulltext Access 11 Pages 2006
Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines Fulltext Access 11 Pages 2006
Aryl nucleoside H-phosphonates. Part 15: Synthesis, properties and, anti-HIV activity of aryl nucleoside 5′-α-hydroxyphosphonates Fulltext Access 11 Pages 2006
Synthesis and biological activity of novel 4,4-difluorobenzazepine derivatives as non-peptide antagonists of the arginine vasopressin V1A receptor Fulltext Access 11 Pages 2006
Biomimetic synthesis, antimicrobial, antileishmanial and antimalarial activities of euglobals and their analogues Fulltext Access 11 Pages 2006
Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the μ-opioid receptor and I2–imidazoline binding sites Fulltext Access 11 Pages 2006
Synthesis and biological evaluation of 9-(5′,5′-difluoro-5′-phosphonopentyl)guanine derivatives for PNP-inhibitors Fulltext Access 11 Pages 2006
Structure–activity relationships of a series of tariquidar analogs as multidrug resistance modulators Fulltext Access 11 Pages 2006
Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase–dihydropteroate synthase Fulltext Access 11 Pages 2006
Neamine derivatives having a nucleobase with a lysine or an arginine as a linker, their synthesis and evaluation as potential inhibitors for HIV TAR–Tat Fulltext Access 11 Pages 2006
α-Peptide/β-sulfonamidopeptide hybrids: Analogs of the chemotactic agent for-Met-Leu-Phe-OMe Fulltext Access 11 Pages 2006
Synthesis and anti-inflammatory activity of a series of N-substituted naproxen glycolamides: Nitric oxide-donor naproxen prodrugs Fulltext Access 11 Pages 2006
Design, synthesis, and biological evaluation of substituted 3-alkylthio-4,5-diaryl-4H-1,2,4-triazoles as selective COX-2 inhibitors Fulltext Access 11 Pages 2006
2,4-Diamino-9H-pyrimido[4,5-b]indol-5-ols: Synthesis, in vitro cytotoxic activity, and QSAR investigations Fulltext Access 11 Pages 2006
Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 1: Synthesis and inhibitory activity of 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamides Fulltext Access 11 Pages 2006
Synthesis and DNA cleavage reaction characteristics of enediyne prodrugs activated via an allylic rearrangement by base or UV irradiation Fulltext Access 11 Pages 2006
Synthesis and antimicrobial activity of new (4,4,4-trihalo-3-oxo-but-1-enyl)-carbamic acid ethyl esters, (4,4,4-trihalo-3-hydroxy-butyl)-carbamic acid ethyl esters, and 2-oxo-6-trihalomethyl-[1,3]oxazinane-3-carboxylic acid ethyl esters Fulltext Access 11 Pages 2006
Synthesis and preliminary chemotherapeutic evaluation of the fully C-linked glucuronide of N-(4-hydroxyphenyl)retinamide Fulltext Access 11 Pages 2006
Preparation of antibodies against a novel immunosuppressant, FTY720, and development of an enzyme immunoassay for FTY720 Fulltext Access 11 Pages 2006
β-Nitrostyrene derivatives as potential antibacterial agents: A structure–property–activity relationship study Fulltext Access 11 Pages 2006
Isoxazole-type derivatives related to combretastatin A-4, synthesis and biological evaluation Fulltext Access 11 Pages 2006
Synthesis of pyrazole-based hybrid molecules: Search for potent multidrug resistance modulators Fulltext Access 11 Pages 2006
Transformations of bioactive peptides in the presence of sugars—Characterization and stability studies of the adducts generated via the Maillard reaction Fulltext Access 11 Pages 2006
Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening Fulltext Access 11 Pages 2006
Synthesis and biological evaluation of homoserine lactone derived ureas as antagonists of bacterial quorum sensing Fulltext Access 11 Pages 2006
Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin Fulltext Access 11 Pages 2006
Molecular docking study and development of an empirical binding free energy model for phosphodiesterase 4 inhibitors Fulltext Access 11 Pages 2006
Atom-based 3D-chiral quadratic indices. Part 2: Prediction of the corticosteroid-binding globulinbinding affinity of the 31 benchmark steroids data set Fulltext Access 11 Pages 2006
Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-d-xylulose 5-phosphate reductoisomerase Fulltext Access 11 Pages 2006
Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives Fulltext Access 11 Pages 2006
Syntheses and evaluation of fluorinated conformationally restricted analogues of GABA as potential inhibitors of GABA aminotransferase Fulltext Access 11 Pages 2006
Binding of oxalyl derivatives of β-d-glucopyranosylamine to muscle glycogen phosphorylase b Fulltext Access 11 Pages 2006
Synthesis and radiosynthesis of [18F]FPhEP, a novel α4β2-selective, epibatidine-based antagonist for PET imaging of nicotinic acetylcholine receptors Fulltext Access 11 Pages 2006
Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles Fulltext Access 11 Pages 2006
Phosphatidylinositol mannosides: Synthesis and suppression of allergic airway disease Fulltext Access 11 Pages 2006
Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline γ- and δ-lactams via a ‘catch and release’ protocol Fulltext Access 11 Pages 2006