Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay Fulltext Access 16 Pages 2006
Design, synthesis, and biological evaluation of chicoric acid analogs as inhibitors of HIV-1 integrase Fulltext Access 16 Pages 2006
Affinity prediction on A1 adenosine receptor agonists: The chemometric approach Fulltext Access 16 Pages 2006
Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3 Fulltext Access 16 Pages 2006
A platform for designing HIV integrase inhibitors. Part 1: 2-Hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores Fulltext Access 16 Pages 2006
Preparation of fluorescent tocopherols for use in protein binding and localization with the α-tocopherol transfer protein Fulltext Access 16 Pages 2006
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors Fulltext Access 16 Pages 2006
Loss of secreted antibody from transgenic plant tissue cultures due to surface adsorption Fulltext Access 16 Pages 2006
Synthesis and antimicrobial evaluation of new 2-substituted 5,7-di-tert-butylbenzoxazoles Fulltext Access 16 Pages 2006
Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors Fulltext Access 16 Pages 2006
Design, synthesis and early structure–activity relationship of farnesyltransferase inhibitors which mimic both the peptidic and the prenylic substrate Fulltext Access 16 Pages 2006
Novel glycosylation methods and their application to natural products synthesis Fulltext Access 16 Pages 2006
A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues Fulltext Access 16 Pages 2006
Hydrophilic photolabelling of glycopeptides from the murine liver–intestine (LI) cadherin recognition domain Fulltext Access 16 Pages 2006
Crystal Structures of Mouse 17α-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17α-reductive Activity of this Enzyme Fulltext Access 17 Pages 2006
Integrated operation of continuous chromatography and biotransformations for the generic high yield production of fine chemicals Fulltext Access 17 Pages 2006
Detection of correlated dynamics on multiple timescales by measurement of the differential relaxation of zero- and double-quantum coherences involving sidechain methyl groups in proteins Fulltext Access 17 Pages 2006
Mitochondrial localization of CNP2 is regulated by phosphorylation of the N-terminal targeting signal by PKC: Implications of a mitochondrial function for CNP2 in glial and non-glial cells Fulltext Access 17 Pages 2006
Integrin-linked kinase regulates Bergmann glial differentiation during cerebellar development Fulltext Access 17 Pages 2006
Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome Fulltext Access 17 Pages 2006
Transcription of gonadotropin β subunit genes involves cross-talk between the transcription factors and co-regulators that mediate actions of the regulatory hormones Fulltext Access 17 Pages 2006
Sequence Dependence of BNIP3 Transmembrane Domain Dimerization Implicates Side-chain Hydrogen Bonding and a Tandem GxxxG Motif in Specific Helix–Helix Interactions Fulltext Access 17 Pages 2006
Structural Determinants of Natriuretic Peptide Receptor Specificity and Degeneracy Fulltext Access 17 Pages 2006
Solution NMR Structure of the Junction between Tropomyosin Molecules: Implications for Actin Binding and Regulation Fulltext Access 17 Pages 2006
In Silico Approaches Reveal the Potential for DNA Sequence-dependent Histone Octamer Affinity to Influence Chromatin Structure in Vivo Fulltext Access 17 Pages 2006
The Folding Energy Landscape of the Dimerization Domain of Escherichia coli Trp Repressor: A Joint Experimental and Theoretical Investigation Fulltext Access 17 Pages 2006
Electron Tomography of Swollen Rigor Fibers of Insect Flight Muscle Reveals a Short and Variably Angled S2 Domain Fulltext Access 17 Pages 2006
Binding Site Structure of One LRP–RAP Complex:Implications for a Common Ligand–Receptor Binding Motif Fulltext Access 17 Pages 2006
Molecular Details of cAMP Generation in Mammalian Cells: A Tale of Two Systems Fulltext Access 17 Pages 2006
Structure of Aart, a Designed Six-finger Zinc Finger Peptide, Bound to DNA Fulltext Access 17 Pages 2006
Evolutionary relationships among the Scarabaeini (Coleoptera: Scarabaeidae) based on combined molecular and morphological data Fulltext Access 17 Pages 2006
Collagen orientation patterns in human secondary osteons, quantified in the radial direction by confocal microscopy Fulltext Access 17 Pages 2006
Molecular phylogeny and phylogeography of the Australian Diplodactylus stenodactylus (Gekkota; Reptilia) species-group based on mitochondrial and nuclear genes reveals an ancient split between Pilbara and non-Pilbara D. stenodactylus Fulltext Access 17 Pages 2006
Molecular phylogeny of the Arctoidea (Carnivora): Effect of missing data on supertree and supermatrix analyses of multiple gene data sets Fulltext Access 17 Pages 2006
Hybridization in coral reef fishes: Introgression and bi-directional gene exchange in Thalassoma (family Labridae) Fulltext Access 17 Pages 2006
Mitochondrial and nuclear phylogenies of Cervidae (Mammalia, Ruminantia): Systematics, morphology, and biogeography Fulltext Access 17 Pages 2006
Heterologous expression of proteins from Plasmodium falciparum: Results from 1000 genes Fulltext Access 17 Pages 2006
Phylogeny, historical biogeography, and patterns of diversification for Pinus (Pinaceae): Phylogenetic tests of fossil-based hypotheses Fulltext Access 17 Pages 2006
Molecular phylogeny of the Drosophila virilis section (Diptera: Drosophilidae) based on mitochondrial and nuclear sequences Fulltext Access 17 Pages 2006
Phylogenetic relationships of horned lizards (Phrynosoma) based on nuclear and mitochondrial data: Evidence for a misleading mitochondrial gene tree Fulltext Access 17 Pages 2006
Phylogeny and biogeography of Altingiaceae: Evidence from combined analysis of five non-coding chloroplast regions Fulltext Access 17 Pages 2006
Characterization of novel splice variants of the PAC1 receptor in human neuroblastoma cells: Consequences for signaling by VIP and PACAP Fulltext Access 17 Pages 2006
Experimental investigation of the elastic–plastic deformation of mineralized lobster cuticle by digital image correlation Fulltext Access 17 Pages 2006
Mechanisms of antimicrobial peptide action: Studies of indolicidin assembly at model membrane interfaces by in situ atomic force microscopy Fulltext Access 17 Pages 2006
Are crocodiles really monophyletic?—Evidence for subdivisions from sequence and morphological data Fulltext Access 17 Pages 2006
The Alexander Disease–Causing Glial Fibrillary Acidic Protein Mutant, R416W, Accumulates into Rosenthal Fibers by a Pathway That Involves Filament Aggregation and the Association of αB-Crystallin and HSP27 Fulltext Access 17 Pages 2006
Phylogeny of Arthropoda inferred from mitochondrial sequences: Strategies for limiting the misleading effects of multiple changes in pattern and rates of substitution Fulltext Access 17 Pages 2006
Evolution of myelin proteolipid proteins: Gene duplication in teleosts and expression pattern divergence Fulltext Access 17 Pages 2006
The ectopic expression of the rice Osmyb4 gene in Arabidopsis increases tolerance to abiotic, environmental and biotic stresses Fulltext Access 17 Pages 2006
Further optimization of sulfonamide analogs as EP1 receptor antagonists: Synthesis and evaluation of bioisosteres for the carboxylic acid group Fulltext Access 17 Pages 2006
Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides Fulltext Access 17 Pages 2006
Nonsteroidal progesterone receptor ligands (II); synthesis and SAR of new tetrahydrobenzindolone derivatives Fulltext Access 17 Pages 2006
Discovery of thiochroman and chroman derivatives as pure antiestrogens and their structure–activity relationship Fulltext Access 17 Pages 2006
Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: Synthesis and structure–activity relationships of a peptide scaffold Fulltext Access 17 Pages 2006
Pyrrolo[2,3-h]quinolinones: A new ring system with potent photoantiproliferative activity Fulltext Access 17 Pages 2006
Pyranocoumarin, a novel anti-TB pharmacophore: Synthesis and biological evaluation against Mycobacterium tuberculosis Fulltext Access 17 Pages 2006
Design, synthesis, and evaluation of Leu∗Ala hydroxyethylene-based non-peptide β-secretase (BACE) inhibitors Fulltext Access 17 Pages 2006
Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents Fulltext Access 17 Pages 2006
Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors Fulltext Access 17 Pages 2006
High-throughput screening of ecdysone agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity Fulltext Access 17 Pages 2006
Synthesis and metabolism of naphthyl substituted phosphoramidate derivatives of stavudine Fulltext Access 17 Pages 2006
Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability Fulltext Access 17 Pages 2006
Structure–activity relationships in platelet-activating factor. Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity Fulltext Access 17 Pages 2006
Characterization of benzaldehyde lyase from Pseudomonas fluorescens: A versatile enzyme for asymmetric C–C bond formation Fulltext Access 17 Pages 2006
Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate Fulltext Access 17 Pages 2006
Thermodynamics of microbial growth and metabolism: An analysis of the current situation Fulltext Access 17 Pages 2006
Constant specific growth rate in fed-batch cultivation of Bordetella pertussis using adaptive control Fulltext Access 17 Pages 2006
The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related aryl tetralin lignans Fulltext Access 17 Pages 2006
Structural and functional consequences of c-N-Ras constitutively associated with intact mitochondria Fulltext Access 17 Pages 2006
P68 RNA Helicase Mediates PDGF-Induced Epithelial Mesenchymal Transition by Displacing Axin from β-Catenin Fulltext Access 17 Pages 2006
Why iron-dithiocarbamates ensure detection of nitric oxide in cells and tissues Fulltext Access 17 Pages 2006
A novel lignan composition from Cedrus deodara induces apoptosis and early nitric oxide generation in human leukemia Molt-4 and HL-60 cells Fulltext Access 17 Pages 2006
Flightless rails endemic to islands have lower energy expenditures and clutch sizes than flighted rails on islands and continents Fulltext Access 17 Pages 2006
Between a rock and a hard place: Trace element nutrition in Chlamydomonas Fulltext Access 17 Pages 2006
Towards a Comprehensive Analysis of the Protein Phosphatase 1 Interactome in Drosophila Fulltext Access 17 Pages 2006
Progress towards understanding disease mechanisms in small vertebrate models of neuronal ceroid lipofuscinosis Fulltext Access 17 Pages 2006
Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target Fulltext Access 17 Pages 2006
A stereoselective 1,2-cis glycosylation toward the synthesis of a novel N-linked glycan from the Gram-negative bacterium, Campylobacter jejuni Fulltext Access 17 Pages 2006
De novo asymmetric syntheses of C-4-substituted sugars via an iterative dihydroxylation strategy Fulltext Access 17 Pages 2006
Design and synthesis of novel 7-heterocycle-6-trifluoromethyl-3-oxoquinoxaline-2-carboxylic acids bearing a substituted phenyl group as superior AMPA receptor antagonists with good physicochemical properties Fulltext Access 17 Pages 2006