Structural Basis of the Nickel Response in Helicobacter pylori: Crystal Structures of HpNikR in Apo and Nickel-bound States Fulltext Access 16 Pages 2006
Transition-state Complex of the Purine-specific Nucleoside Hydrolase of T. vivax: Enzyme Conformational Changes and Implications for Catalysis Fulltext Access 16 Pages 2006
Characterization of Intra-molecular Distances and Site-specific Dynamics in Chemically Unfolded Barstar: Evidence for Denaturant-dependent Non-random Structure Fulltext Access 16 Pages 2006
The Asymmetric IscA Homodimer with an Exposed [2Fe-2S] Cluster Suggests the Structural Basis of the Fe-S Cluster Biosynthetic Scaffold Fulltext Access 16 Pages 2006
DM2 CCTG•CAGG Repeats are Crossover Hotspots that are More Prone to Expansions than the DM1 CTG•CAG Repeats in Escherichia coli Fulltext Access 16 Pages 2006
Tetramerization of the LexA Repressor in Solution: Implications for Gene Regulation of the E. coli SOS System at Acidic pH Fulltext Access 16 Pages 2006
Identification of the PXW Sequence as a Structural Gatekeeper of the Headpiece C-terminal Subdomain Fold Fulltext Access 16 Pages 2006
Structural Recognition between a Four-way DNA Junction and a Resolving Enzyme Fulltext Access 16 Pages 2006
Histidine Triad-like Motif of the Rotavirus NSP2 Octamer Mediates both RTPase and NTPase Activities Fulltext Access 16 Pages 2006
Transmission Electron Microscopy Reveals an Optimal HIV-1 Nucleocapsid Aggregation with Single-stranded Nucleic Acids and the Mature HIV-1 Nucleocapsid Protein Fulltext Access 16 Pages 2006
Unbound and Acylated Structures of the MecR1 Extracellular Antibiotic-sensor Domain Provide Insights into the Signal-transduction System that Triggers Methicillin Resistance Fulltext Access 16 Pages 2006
Location of High and Low Affinity Fatty Acid Binding Sites on Human Serum Albumin Revealed by NMR Drug-competition Analysis Fulltext Access 16 Pages 2006
Small Proteins Fold Through Transition States With Native-like Topologies Fulltext Access 16 Pages 2006
Molecular Structure of fd (f1, M13) Filamentous Bacteriophage Refined with Respect to X-ray Fibre Diffraction and Solid-state NMR Data Supports Specific Models of Phage Assembly at the Bacterial Membrane Fulltext Access 16 Pages 2006
The Myosin Filament Superlattice in the Flight Muscles of Flies: A-band Lattice Optimisation for Stretch-activation? Fulltext Access 16 Pages 2006
Visualizing the Assembly of Human Rad51 Filaments on Double-stranded DNA Fulltext Access 16 Pages 2006
Flexibility and Adaptability in Binding of E. coli Cytidine Repressor to Different Operators Suggests a Role in Differential Gene Regulation Fulltext Access 16 Pages 2006
The Human IgE-encoding Transcriptome to Assess Antibody Repertoires and Repertoire Evolution Fulltext Access 16 Pages 2006
Methyl Substituents at the 11 or 12 Position of Retinal Profoundly and Differentially Affect Photochemistry and Signalling Activity of Rhodopsin Fulltext Access 16 Pages 2006
A Counterintuitive Mg2+-dependent and Modification-assisted Functional Folding of Mitochondrial tRNAs Fulltext Access 16 Pages 2006
Crystal Structures of the AppA BLUF Domain Photoreceptor Provide Insights into Blue Light-mediated Signal Transduction Fulltext Access 16 Pages 2006
Structure, Function and Dynamics in the mur Family of Bacterial Cell Wall Ligases Fulltext Access 16 Pages 2006
The 15 SCR Flexible Extracellular Domains of Human Complement Receptor Type 2 can Mediate Multiple Ligand and Antigen Interactions Fulltext Access 16 Pages 2006
Structural Basis for Nucleic Acid and Toxin Recognition of the Bacterial Antitoxin CcdA Fulltext Access 16 Pages 2006
Exploring Transcription Factor Binding Properties of Several Non-coding DNA Sequence Elements in the Human NF-IL6 Gene Fulltext Access 16 Pages 2006
Two-dimensional hyperfine sublevel correlation spectroscopy: Powder features for SÂ =Â 1/2, IÂ =Â 1 Fulltext Access 16 Pages 2006
Spatial encoding and the single-scan acquisition of high definition MR images in inhomogeneous fields Fulltext Access 16 Pages 2006
Effects of oxidative stress on the cardiac myocyte proteome: modifications to peroxiredoxins and small heat shock proteins Fulltext Access 16 Pages 2006
Three Key Residues Underlie the Differential Affinity of the TGFβ Isoforms for the TGFβ Type II Receptor Fulltext Access 16 Pages 2006
Engineering of Large Numbers of Highly Specific Homing Endonucleases that Induce Recombination on Novel DNA Targets Fulltext Access 16 Pages 2006
DNA Binding Domains and Nuclear Localization Signal of LEDGF: Contribution of two Helix-Turn-Helix (HTH)-like Domains and a Stretch of 58 Amino Acids of the N-terminal to the Trans-activation Potential of LEDGF Fulltext Access 16 Pages 2006
Rigidity and Flexibility of Dipeptidyl Peptidase IV: Crystal Structures of and Docking Experiments with DPIV Fulltext Access 16 Pages 2006
A Single Mutation Induces Amyloid Aggregation in the α-Spectrin SH3 Domain: Analysis of the Early Stages of Fibril Formation Fulltext Access 16 Pages 2006
Extended Flexible Linker Structures in the Complement Chimaeric Conjugate CR2-Ig by Scattering, Analytical Ultracentrifugation and Constrained Modelling: Implications for Function and Therapy Fulltext Access 16 Pages 2006
Phage Display Reveals Multiple Contact Sites between FhuA, an Outer Membrane Receptor of Escherichia coli, and TonB † Fulltext Access 16 Pages 2006
Elucidation of Human Choline Kinase Crystal Structures in Complex with the Products ADP or Phosphocholine Fulltext Access 16 Pages 2006
Multi-step Assembly Pathway of the cbb3-type Cytochrome c Oxidase Complex Fulltext Access 16 Pages 2006
Crystal Structure of the Archaeal A1AO ATP Synthase Subunit B from Methanosarcina mazei Gö1: Implications of Nucleotide-binding Differences in the Major A1AO Subunits A and B Fulltext Access 16 Pages 2006
A Molecular Dynamics Approach to the Structural Characterization of Amyloid Aggregation Fulltext Access 16 Pages 2006
Effects of Calcium Binding on the Side-chain Methyl Dynamics of Calbindin D9k: A 2H NMR Relaxation Study Fulltext Access 16 Pages 2006
Molecular Mechanisms of PKCα localization and Activation by Arachidonic Acid. The C2 Domain also Plays a Role Fulltext Access 16 Pages 2006
Uncoupling of RNA Binding and PKR Kinase Activation by Viral Inhibitor RNAs Fulltext Access 16 Pages 2006
Solution Conformation and Heparin-induced Dimerization of the Full-length Extracellular Domain of the Human Amyloid Precursor Protein Fulltext Access 16 Pages 2006
GroEL Walks the Fine Line: The Subtle Balance of Substrate and Co-chaperonin Binding by GroEL. A Combinatorial Investigation by Design, Selection and Screening Fulltext Access 16 Pages 2006
Computational Study of the Fibril Organization of Polyglutamine Repeats Reveals a Common Motif Identified in β-Helices Fulltext Access 16 Pages 2006
A Critical Coiled Coil Motif in the Small Terminase, gp16, from Bacteriophage T4: Insights into DNA Packaging Initiation and Assembly of Packaging Motor Fulltext Access 16 Pages 2006
Structure–activity relationship studies of resveratrol and its analogues by the reaction kinetics of low density lipoprotein peroxidation Fulltext Access 16 Pages 2006
BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane–cytosol interfaces and membrane curvature Fulltext Access 16 Pages 2006
Glyconanoparticles: Types, synthesis and applications in glycoscience, biomedicine and material science Fulltext Access 16 Pages 2006
Mitochondrial contact sites: Their role in energy metabolism and apoptosis Fulltext Access 16 Pages 2006
Enantioselective synthesis of 1-methoxy- and 1-deoxy-2′-methyl-Δ8-tetrahydrocannabinols: New selective ligands for the CB2 receptor Fulltext Access 16 Pages 2006
Synthesis, in vitro pharmacology, and structure–activity relationships of 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as mGluR2 antagonists Fulltext Access 16 Pages 2006
Potent inhibitors of the hepatitis C virus NS3 protease: Use of a novel P2 cyclopentane-derived template Fulltext Access 16 Pages 2006
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450 Fulltext Access 16 Pages 2006
Optimization of sulfonamide derivatives as highly selective EP1 receptor antagonists Fulltext Access 16 Pages 2006
Glycosyl bis-porphyrin conjugates: Synthesis and potential application in PDT Fulltext Access 16 Pages 2006
Reaction of epichlorohydrin with adenosine, 2â²-deoxyadenosine and calf thymus DNA: Identification of adducts Fulltext Access 16 Pages 2006
Diversification of function in the haloacid dehalogenase enzyme superfamily: The role of the cap domain in hydrolytic phosphoruscarbon bond cleavage Fulltext Access 16 Pages 2006
Payne rearrangement during analysis of epoxyalcohols of linoleic and α-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry Fulltext Access 16 Pages 2006
Analysis of recombinant monoclonal antibody isoforms by electrospray ionization mass spectrometry as a strategy for streamlining characterization of recombinant monoclonal antibody charge heterogeneity Fulltext Access 16 Pages 2006
A dimensionless number analysis of the hybridization process in diffusion- and convection-driven DNA microarray systems Fulltext Access 16 Pages 2006
Production of hantavirus Puumala nucleocapsid protein in Saccharomyces cerevisiae for vaccine and diagnostics Fulltext Access 16 Pages 2006
A comparison of mineral affinity of bisphosphonate–protein conjugates constructed with disulfide and thioether linkages Fulltext Access 16 Pages 2006
Soluble osteogenic molecular signals and the induction of bone formation Fulltext Access 16 Pages 2006
Cluster analysis and gene expression profiles: A cDNA microarray system-based comparison between human dental pulp stem cells (hDPSCs) and human mesenchymal stem cells (hMSCs) for tissue engineering cell therapy Fulltext Access 16 Pages 2006
Dynamics of heart differentiation, visualized utilizing heart enhancer elements of the Drosophila melanogaster bHLH transcription factor Hand Fulltext Access 16 Pages 2006
Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): Comparative gene and protein expression during larval development through adulthood Fulltext Access 16 Pages 2006
Identification of the down-regulated genes in a mat1-2-deleted strain of Gibberella zeae, using cDNA subtraction and microarray analysis Fulltext Access 16 Pages 2006
High-specificity and high-sensitivity genotoxicity assessment in a human cell line: Validation of the GreenScreen HC GADD45a-GFP genotoxicity assay Fulltext Access 16 Pages 2006
Antioxidants prevent oxidative DNA damage and cellular transformation elicited by the over-expression of c-MYC Fulltext Access 16 Pages 2006
Overlapping contributions of Msh1p and putative recombination proteins Cce1p, Din7p, and Mhr1p in large-scale recombination and genome sorting events in the mitochondrial genome of Saccharomyces cerevisiae Fulltext Access 16 Pages 2006
2-Methoxyestradiol and paclitaxel have similar effects on the cell cycle and induction of apoptosis in prostate cancer cells Fulltext Access 16 Pages 2006
A Comparison of Cyclophosphamide and Total Body Irradiation with Etoposide and Total Body Irradiation as Conditioning Regimens for Patients Undergoing Sibling Allografting for Acute Lymphoblastic Leukemia in First or Second Complete Remission Fulltext Access 16 Pages 2006
Dynamics of NO rebinding to the heme domain of NO synthase-like proteins from bacterial pathogens Fulltext Access 16 Pages 2006
Specific protein kinase C isoforms as transducers and modulators of insulin signaling Fulltext Access 16 Pages 2006
Quantitative kinetic analysis of gene expression during human osteoblastic adhesion on orthopaedic materials Fulltext Access 16 Pages 2006
Roles of E. coli double-strand-break-repair proteins in stress-induced mutation Fulltext Access 16 Pages 2006
DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells Fulltext Access 16 Pages 2006
Mgs1 and Rad18/Rad5/Mms2 are required for survival of Saccharomyces cerevisiae mutants with novel temperature/cold sensitive alleles of the DNA polymerase δ subunit, Pol31 Fulltext Access 16 Pages 2006
Chromatin structural elements and chromosomal translocations in leukemia Fulltext Access 16 Pages 2006
Analysis of mutagenic V(D)J recombinase mediated mutations at the HPRT locus as an in vivo model for studying rearrangements with leukemogenic potential in children Fulltext Access 16 Pages 2006
Cell signalling diversity of the Gqα family of heterotrimeric G proteins Fulltext Access 16 Pages 2006
Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity Fulltext Access 16 Pages 2006
Multiple receptor states are required to describe both kinetic binding and activation of neutrophils via N-formyl peptide receptor ligands Fulltext Access 16 Pages 2006
Mechanisms of iron–sulfur protein maturation in mitochondria, cytosol and nucleus of eukaryotes Fulltext Access 16 Pages 2006