The characterization of a novel rigid nicotine analog with α7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion Fulltext Access 7 Pages 2005
Design and synthesis of an optimized positional scanning library of peptoids: identification of novel multidrug resistance reversal agents Fulltext Access 7 Pages 2005
3-Aminomethyl derivatives of 4,11-dihydroxynaphtho[2,3-f]indole-5,10-dione for circumvention of anticancer drug resistance Fulltext Access 7 Pages 2005
Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors Fulltext Access 7 Pages 2005
Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs Fulltext Access 7 Pages 2005
Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid Fulltext Access 7 Pages 2005
Molecular recognition of 15-deoxy-Δ12,14-prostaglandin J2 by nuclear factor-kappa B and other cellular proteins Fulltext Access 7 Pages 2005
Analysis of structure–activity relationships for the ‘A-region’ of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists Fulltext Access 7 Pages 2005
Carbonic anhydrase inhibitors: Design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma Fulltext Access 7 Pages 2005
Oral delivery of G protein-coupled receptor modulators: An explanation for the observed class difference Fulltext Access 7 Pages 2005
QSAR of adenosine A3 receptor antagonist 1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives using chemometric tools Fulltext Access 7 Pages 2005
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors Fulltext Access 7 Pages 2005
Synthesis and structure–activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1) Fulltext Access 7 Pages 2005
Synthesis and bladder smooth muscle relaxing properties of substituted 3-amino-4-aryl-(and aralkyl-)cyclobut-3-ene-1,2-diones Fulltext Access 7 Pages 2005
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure–activity relationships of the 7- and 5-, 6-, 8-positions Fulltext Access 7 Pages 2005
Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines Fulltext Access 7 Pages 2005
Carbonic anhydrase inhibitors: Novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX Fulltext Access 7 Pages 2005
Hologram quantitative structure–activity relationships for a series of farnesoid X receptor activators Fulltext Access 7 Pages 2005
QSAR analysis of thiazole benzenesulfonamide substituted 3-pyridylethanolamines as β3-adrenergic receptor agonist Fulltext Access 7 Pages 2005
Parallel solid-phase synthesis and characterization of new sulfonamide and carboxamide proline derivatives as potential CNS agents Fulltext Access 7 Pages 2005
Novel coumarin-3-(N-aryl)carboxamides arrest breast cancer cell growth by inhibiting ErbB-2 and ERK1 Fulltext Access 7 Pages 2005
Novel heterocyclic family of phenyl naphthothiazole carboxamides derived from naphthalimides: synthesis, antitumor evaluation, and DNA photocleavage Fulltext Access 7 Pages 2005
The influence of aromatic residues in hydraphile spacer units: assay by ion selective electrode methods and in bacteria Fulltext Access 7 Pages 2005
Synthesis and evaluation of new ω-borono-α-amino acids as rat liver arginase inhibitors Fulltext Access 7 Pages 2005
Synthesis of novel DNA cross-linking antitumour agents based on polyazamacrocycles Fulltext Access 7 Pages 2005
New sesquiterpenic phytotoxins establish unprecedented relationship between different groups of blackleg fungal isolates Fulltext Access 7 Pages 2005
Benzotropolone inhibitors of estradiol methylation: kinetics and in silico modeling studies Fulltext Access 7 Pages 2005
Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells Fulltext Access 7 Pages 2005
Studies on quinones. Part 39: Synthesis and leishmanicidal activity of acylchloroquinones and hydroquinones Fulltext Access 7 Pages 2005
New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids Fulltext Access 7 Pages 2005
Synthesis of a novel potent cyclic peptide MC4-ligand by ring-closing metathesis Fulltext Access 7 Pages 2005
Correlation of LUMO localization with the α-amylase inhibition constant in a Tendamistat-based series of linear and cyclic peptides Fulltext Access 7 Pages 2005
Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues Fulltext Access 7 Pages 2005
Design, synthesis and cytotoxic effect of hydroxy- and 3-alkylaminopropoxy-9,10-anthraquinone derivatives Fulltext Access 7 Pages 2005
An efficient preparation of polyanionic affinity agent and its evaluation for the measurement of glycated hemoglobin Fulltext Access 7 Pages 2005
Synthesis and biological evaluation of N-{4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl}-l-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway Fulltext Access 7 Pages 2005
Isolation of brominated quinones showing chemiluminescence activity from luminous acorn worm, Ptychodera flava Fulltext Access 7 Pages 2005
2,4,6-Trisubstituted pyrimidine derivatives as pregnancy interceptive agents Fulltext Access 7 Pages 2005
Design, synthesis, and anti-tumor activity of (2-O-alkyloxime-3-phenyl)-propionyl-1-O-acetylbritannilactone esters Fulltext Access 7 Pages 2005
(R)-Goniothalamin: total syntheses and cytotoxic activity against cancer cell lines Fulltext Access 7 Pages 2005
QSAR by LFER model of cytotoxicity data of anti-HIV 5-phenyl-1-phenylamino-1H-imidazole derivatives using principal component factor analysis and genetic function approximation Fulltext Access 7 Pages 2005
Spectrometric studies of cytotoxic protoberberine alkaloids binding to double-stranded DNA Fulltext Access 8 Pages 2005
Classical and three-dimensional QSAR for the inhibition of [3H]ponasterone A binding by diacylhydrazine-type ecdysone agonists to insect Sf-9 cells Fulltext Access 8 Pages 2005
Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis Fulltext Access 8 Pages 2005
Synthesis and evaluation of N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoromethoxy-d2-5-methoxybenzyl)acetamide: a deuterium-substituted radioligand for peripheral benzodiazepine receptor Fulltext Access 8 Pages 2005
Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles Fulltext Access 8 Pages 2005
Synthesis and cellular studies of an octa-anionic 5,10,15,20-tetra[3,5-(nido-carboranylmethyl)phenyl]porphyrin (H2OCP) for application in BNCT Fulltext Access 8 Pages 2005
Thio-heterocylic naphthalimides with aminoalkyl side chains: novel alternative tools for photodegradation of genomic DNA without impairment on bioactivities of proteins Fulltext Access 8 Pages 2005
Synthesis and biodistribution of [11C]R116301, a promising PET ligand for central NK1 receptors Fulltext Access 8 Pages 2005
Synthesis and anticancer activity of benzyloxybenzaldehyde derivatives against HL-60 cells Fulltext Access 8 Pages 2005
3D QSAR Markov model for drug-induced eosinophilia-theoretical prediction and preliminary experimental assay of the antimicrobial drug G1 Fulltext Access 8 Pages 2005
Synthesis and hybridization properties of the conjugates of oligonucleotides and stabilization agents. Part 3 Fulltext Access 8 Pages 2005
Quantitative structure and aldose reductase inhibitory activity relationship of 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3â²-pyrrolidine-1,2â²,3,5â²-tetrone derivatives Fulltext Access 8 Pages 2005
Synthesis of 2-amino-6-(4-[11C]methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester as a novel potential PET gene reporter probe for HBV and HSV-tk in cancers Fulltext Access 8 Pages 2005
Effects of 8-methyl-2â²-deoxyadenosine incorporation into quadruplex forming oligodeoxyribonucleotides Fulltext Access 8 Pages 2005
Inhibition of classical pathway of complement activation with negative charged derivatives of bisphenol A and bisphenol disulphates Fulltext Access 8 Pages 2005
Nγ-Aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site Fulltext Access 8 Pages 2005
NMR conformational analysis of p-tolyl furanopyrimidine 2â²-deoxyribonucleoside and crystal structure of its 3â²,5â²-di-O-acetyl derivative Fulltext Access 8 Pages 2005
Formylchromone derivatives as irreversible and selective inhibitors of human protein tyrosine phosphatase 1B. Kinetic and modeling studies Fulltext Access 8 Pages 2005
Synthesis and photodynamic activity of zinc(II) phthalocyanine derivatives bearing methoxy and trifluoromethylbenzyloxy substituents in homogeneous and biological media Fulltext Access 8 Pages 2005
New antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides Fulltext Access 8 Pages 2005
Selective interactions of perylene derivatives having different side chains with inter- and intramolecular G-quadruplex DNA structures. A correlation with telomerase inhibition Fulltext Access 8 Pages 2005
Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases Fulltext Access 8 Pages 2005
QSAR studies on benzene sulfonamide carbonic anhydrase inhibitors: need of hydrophobic parameter for topological modeling of binding constants of sulfonamides to human CA-II Fulltext Access 8 Pages 2005
Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors Fulltext Access 8 Pages 2005
QSAR studies on structurally similar 2-(4-methanesulfonylphenyl)pyran-4-ones as selective COX-2 inhibitors: a Hansch approach Fulltext Access 8 Pages 2005
Polymorphism of monolayer lipid membrane structures made from unsymmetrical bolaamphiphiles Fulltext Access 8 Pages 2005
Analysis of structure–activity relationships for the ‘B-region’ of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists Fulltext Access 8 Pages 2005
Synthesis and in vitro cytotoxicity of novel hydrophilic chiral 2-alkoxy-1,4-butanediamine platinum (II) complexes Fulltext Access 8 Pages 2005
Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors Fulltext Access 8 Pages 2005
Study on supramolecular complexing ability vis-à-vis estimation of pKa of substituted sulfonamides: Dominating role of Balaban index (J) Fulltext Access 8 Pages 2005
Tetra substituted thiophenes as anti-inflammatory agents: Exploitation of analogue-based drug design Fulltext Access 8 Pages 2005
Cloning, expression, and characterization of an oligoxyloglucan reducing end-specific xyloglucanobiohydrolase from Aspergillus nidulans Fulltext Access 8 Pages 2005
Synthesis of d-lyxitol and d-ribitol analogues of the naturally occurring glycosidase inhibitor salacinol Fulltext Access 8 Pages 2005
Molecular characterisation of soybean polysaccharides: an approach by size exclusion chromatography, dynamic and static light scattering methods Fulltext Access 8 Pages 2005
An efficient synthesis of methyl 1,3-O-isopropylidene-α-d-fructofuranoside and 2,3:5,6-di-O-isopropylidene-d-glucose dimethyl acetal derivatives from sucrose Fulltext Access 8 Pages 2005
Structure-activity relationship study on 13-deoxytedanolide, a highly antitumor macrolide from the marine sponge Mycale adhaerens Fulltext Access 8 Pages 2005
The α-(1→6) glycosidic linkage as a novel conformational entropic regulator in osmoregulated periplasmic α-cyclosophorohexadecaose Fulltext Access 8 Pages 2005
Investigations of different carbohydrate anomers in copper(II) complexes with d-glucose, d-fructose, and d-galactose by Raman and EPR spectroscopy Fulltext Access 8 Pages 2005
The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation Fulltext Access 8 Pages 2005
Synthesis of methyl 4′-O-methyl-13C12-β-d-cellobioside from 13C6-d-glucose. Part 1: Reaction optimization and synthesis Fulltext Access 8 Pages 2005
Preparation of the methyl ester of hyaluronan and its enzymatic degradation Fulltext Access 8 Pages 2005
Solid and solution state conformations of (±)-3-O-acetyl-1,2:4,5-di-O-isopropylidene-allo-inositol and (±)-3-O-acetyl-1,2:4,5-di-O-isopropylidene-6-O-methyl-allo-inositol Fulltext Access 8 Pages 2005
A radial distribution function approach to predict A2B agonist effect of adenosine analogues Fulltext Access 8 Pages 2005
Synthesis and structure-activity relationships of 6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide derivatives as a novel class of NCX inhibitors: a QSAR study Fulltext Access 8 Pages 2005
Binding of β-d-glucopyranosyl bismethoxyphosphoramidate to glycogen phosphorylase b: kinetic and crystallographic studies Fulltext Access 8 Pages 2005
Design and synthesis of (Z)-1,2-diphenyl-1-(4-methanesulfonamidophenyl)alk-1-enes and (Z)-1-(4-azidophenyl)-1,2-diphenylalk-1-enes: novel inhibitors of cyclooxygenase-2 (COX-2) with anti-inflammatory and analgesic activity Fulltext Access 8 Pages 2005
Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate Fulltext Access 8 Pages 2005