Auto-induction medium for the production of [U-15N]- and [U-13C, U-15N]-labeled proteins for NMR screening and structure determination Fulltext Access 11 Pages 2005
Exploring human adenosine A3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety Fulltext Access 11 Pages 2005
Cardioprotective activity of melatonin and its novel synthesized derivatives on doxorubicin-induced cardiotoxicity Fulltext Access 11 Pages 2005
Stereochemical influence on lipase-mediated hydrolysis and biological activity of stampidine and other stavudine phosphoramidates Fulltext Access 11 Pages 2005
α-Glucosidase inhibition of 6-hydroxyflavones. Part 3: Synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as α-glucosidase inhibitors Fulltext Access 11 Pages 2005
Synthesis and potent antimicrobial activity of some novel methyl or ethyl 1H-benzimidazole-5-carboxylates derivatives carrying amide or amidine groups Fulltext Access 11 Pages 2005
Identification of peptide ligands for malignancy- and growth-regulating galectins using random phage-display and designed combinatorial peptide libraries Fulltext Access 11 Pages 2005
N-Oxide analogs of WAY-100635: new high affinity 5-HT1A receptor antagonists Fulltext Access 11 Pages 2005
Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases Fulltext Access 11 Pages 2005
2-Aryl-8-chloro-1,2,4-triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists Fulltext Access 11 Pages 2005
Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa Fulltext Access 11 Pages 2005
Purification and characterization of bovine adrenal cytochrome b561 expressed in insect and yeast cell systems Fulltext Access 11 Pages 2005
The pST44 polycistronic expression system for producing protein complexes in Escherichia coli Fulltext Access 11 Pages 2005
Predicting multiple drugs side effects with a general drug-target interaction thermodynamic Markov model Fulltext Access 11 Pages 2005
Membranal effects of phytoestrogens and carboxy derivatives of phytoestrogens on human vascular and bone cells: New insights based on studies with carboxy-biochanin A Fulltext Access 11 Pages 2005
Structural determinants of plant lignans for growth of mammary tumors and hormonal responses in vivo Fulltext Access 11 Pages 2005
Conformational adaptation of nuclear receptor ligand binding domains to agonists: Potential for novel approaches to ligand design Fulltext Access 11 Pages 2005
Estrogen-induced apoptosis in a breast cancer model resistant to long-term estrogen withdrawal Fulltext Access 11 Pages 2005
Innovative drug delivery nanosystems improve the anti-tumor activity in vitro and in vivo of anti-estrogens in human breast cancer and multiple myeloma Fulltext Access 11 Pages 2005
Estrogen receptor α and β subtype expression and transactivation capacity are differentially affected by receptor-, hsp90- and immunophilin-ligands in human breast cancer cells Fulltext Access 11 Pages 2005
The antagonism between 2-methyl-1,25-dihydroxyvitamin D3 and 2-methyl-20-epi-1,25-dihydroxyvitamin D3 in non-genomic pathway-mediated biological responses induced by 1α,25-dihydroxyvitamin D3 assessed by NB4 cell differentiation Fulltext Access 11 Pages 2005
Adaptive hypersensitivity to estrogen: Mechanisms and clinical relevance to aromatase inhibitor therapy in breast cancer treatment Fulltext Access 11 Pages 2005
Brain aromatase in Japanese medaka (Oryzias latipes): Molecular characterization and role in xenoestrogen-induced sex reversal Fulltext Access 11 Pages 2005
Divergent biological effects of estradiol and diethylstilbestrol in the prostate cancer cell line MOP Fulltext Access 11 Pages 2005
Down-regulation of Hsp60 expression by RNAi impairs folding of medium-chain acyl-CoA dehydrogenase wild-type and disease-associated proteins Fulltext Access 11 Pages 2005
Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24: role of the signal sequence and overexpression in Escherichia coli Fulltext Access 11 Pages 2005
Expression and purification of recombinant antigens of Mycobacterium tuberculosis for application in serodiagnosis Fulltext Access 11 Pages 2005
Expression, purification, and biochemical characterization of the intron-encoded endonuclease, I-CreII Fulltext Access 11 Pages 2005
Improved purification of native meningococcal porin PorB and studies on its structure/function Fulltext Access 11 Pages 2005
Expression in Escherichia coli and disulfide bridge mapping of PSC33, an allergenic 2S albumin from peanut Fulltext Access 11 Pages 2005
Overexpression and purification of Pyrococcus abyssi phosphopantetheine adenylyltransferase from an optimized synthetic gene for NMR studies Fulltext Access 11 Pages 2005
Two methods for large-scale purification of recombinant human choline acetyltransferase Fulltext Access 11 Pages 2005
Expression and characterization of human CB1 cannabinoid receptor in methylotrophic yeast Pichia pastoris Fulltext Access 11 Pages 2005
Preparation of specifically activatable endopeptidase derivatives of Clostridium botulinum toxins type A, B, and C and their applications Fulltext Access 11 Pages 2005
Selective quantification of free 3-nitrotyrosine in exhaled breath condensate in asthma using gas chromatography/tandem mass spectrometry Fulltext Access 11 Pages 2005
Influence of nitric oxide donors on the intrinsic fluorescence of Na+,K+-ATPase and effects on the membrane lipids Fulltext Access 11 Pages 2005
Sodium nitroprusside affects the level of photosynthetic enzymes and glucose metabolism in Phaseolus aureus (mung bean) Fulltext Access 11 Pages 2005
Difficulty demonstrating estradiol-mediated Erk1/2 phosphorylation in MCF-7 cells Fulltext Access 11 Pages 2005
Regulation of human erythrocyte metabolism by insulin: Cellular distribution of 6-phosphofructo-1-kinase and its implication for red blood cell function Fulltext Access 11 Pages 2005
Using quantitative imaging microscopy to define the target substrate specificities of histone post-translational-modifying enzymes Fulltext Access 11 Pages 2005
Assays for mechanistic investigations of protein/histone acetyltransferases Fulltext Access 11 Pages 2005
NMR spectroscopy: a powerful tool for detecting the conformational features of symmetrical persubstituted mixed cyclomaltoheptaoses (β-cyclodextrins) Fulltext Access 11 Pages 2005
Synthesis and biological relationships of 3â²,6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents Fulltext Access 11 Pages 2005
Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands Fulltext Access 11 Pages 2005
Photocontrol of nitric oxide production in cell culture using a caged isoform selective inhibitor Fulltext Access 11 Pages 2005
Oligosaccharides as inhibitors of mycobacterial arabinosyltransferases. Di- and trisaccharides containing C-3 modified arabinofuranosyl residues Fulltext Access 11 Pages 2005
Perfluorinated markers for hypoxia detection: synthesis of sulfur-containing precursors and [18F]-labelling Fulltext Access 11 Pages 2005
Binding studies and GRIND/ALMOND-based 3D QSAR analysis of benzothiazine type KATP-channel openers Fulltext Access 11 Pages 2005
Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent Fulltext Access 11 Pages 2005
Exploration of a binding mode of indole amide analogues as potent histone deacetylase inhibitors and 3D-QSAR analyses Fulltext Access 11 Pages 2005
The study on the interaction between seryl-histidine dipeptide and proteins by circular dichroism and molecular modeling Fulltext Access 11 Pages 2005
Fluorinated phenylcyclopropylamines. Part 4: Effects of aryl substituents and stereochemistry on the inhibition of monoamine oxidases by 1-aryl-2-fluoro-cyclopropylamines Fulltext Access 11 Pages 2005
Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product Fulltext Access 11 Pages 2005
Novel cyclosporin derivatives featuring enhanced skin penetration despite increased molecular weight Fulltext Access 11 Pages 2005
Genistein derivatives as selective estrogen receptor modulators: Sonochemical synthesis and in vivo anti-osteoporotic action Fulltext Access 11 Pages 2005
Validation of a histamine H3 receptor model through structure–activity relationships for classical H3 antagonists Fulltext Access 11 Pages 2005
Structure–activity relationships of tyrosinase inhibitory combinatorial library of 2,5-disubstituted-1,3,4-oxadiazole analogues Fulltext Access 11 Pages 2005
Hydrophobic and electronic factors in the design of dialkylglycine decarboxylase mimics Fulltext Access 11 Pages 2005
Branched aminoglycosides: Biochemical studies and antibacterial activity of neomycin B derivatives Fulltext Access 11 Pages 2005
Synthesis and initial PET imaging of new potential dopamine D3 receptor radioligands (E)-4,3,2-[11C]methoxy-N-4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl-cinnamoylamides Fulltext Access 11 Pages 2005
Prostate cancer PET bioprobes: Synthesis of [18F]-radiolabeled hydroxyflutamide derivatives Fulltext Access 11 Pages 2005
Chiral anthracene and anthrone templates as stereocontrolling elements in Diels–Alder/retro Diels–Alder sequences Fulltext Access 11 Pages 2005
Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora Fulltext Access 11 Pages 2005
Biomimetic synthesis of acid-sensitive (−)- and (+)-caparrapi oxides, (−)- and (+)-8-epicaparrapi oxides, and (+)-dysifragin induced by artificial cyclases Fulltext Access 11 Pages 2005
Combined NMR-crystallographic and modelling investigation of the inclusion of molsidomine into α-, β- and γ-cyclodextrins Fulltext Access 11 Pages 2005
Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes Fulltext Access 11 Pages 2005
New potent 5-substituted benzofuroxans as inhibitors of Trypanosoma cruzi growth: Quantitative structure–activity relationship studies Fulltext Access 11 Pages 2005
Structural analysis and antiviral activity of a sulfated galactan from the red seaweed Schizymenia binderi (Gigartinales, Rhodophyta) Fulltext Access 11 Pages 2005
Molecular profile of androgen-independent prostate cancer xenograft LuCaP 23.1 Fulltext Access 11 Pages 2005
Transcriptional inhibition of the estrogen response element by antiestrogenic piperidinediones correlates with intercalation into DNA measured by energy calculations Fulltext Access 11 Pages 2005
Membrane 5α-pregnane-3,20-dione (5αP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5αP and down-regulated by the progesterone metabolites, 3α-dihydroprogesterone and 20α-dihydroprogesterone, with associated cha Fulltext Access 11 Pages 2005
Ospemifene inhibits the growth of dimethylbenzanthracene-induced mammary tumors in Sencar mice Fulltext Access 11 Pages 2005
The c-Yes 3â²-UTR contains adenine/uridine-rich elements that bind AUF1 and HuR involved in mRNA decay in breast cancer cells Fulltext Access 11 Pages 2005
Identification by microarray analysis of aspartate aminotransferase and glutamine synthetase as glucocorticoid target genes in a mouse Schwann cell line Fulltext Access 11 Pages 2005
Modulation of p53 expression and its role in the conversion to a fully immortalized chicken embryo fibroblast line Fulltext Access 11 Pages 2005
Elucidation of subfamily segregation and intramolecular coevolution of the olfactomedin-like proteins by comprehensive phylogenetic analysis and gene expression pattern assessment Fulltext Access 11 Pages 2005
The bovine vitreous-derived lipid factor (bVLF) is a powerful inhibitor of retinal pigmented epithelial (hRPE) cell proliferation Fulltext Access 11 Pages 2005
Identification and characterization of small RNAs involved in RNA silencing Fulltext Access 11 Pages 2005
Construction of chimeric cyclodextrin glucanotransferases from Bacillus circulans A11 and Paenibacillus macerans IAM1243 and analysis of their product specificity Fulltext Access 11 Pages 2005
Structural characterization of a series of 10-carbon sugar derivatives by electrospray-ionization MSn mass spectrometry Fulltext Access 11 Pages 2005
QSAR studies on 1-phenylbenzimidazoles as inhibitors of the platelet-derived growth factor Fulltext Access 11 Pages 2005
Synthesis of N-acylated 7-amino-2,6,7-trideoxy-d-erythroheptopyranosides from methyl α-d-mannoside Fulltext Access 11 Pages 2005
1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), α1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics Fulltext Access 11 Pages 2005
Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with β-secretase Fulltext Access 11 Pages 2005
Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (TAK-802) and related compounds Fulltext Access 11 Pages 2005
Investigations of linker structure on the potency of a series of bidentate protein tyrosine phosphatase inhibitors Fulltext Access 11 Pages 2005
Cytotoxicities, cell cycle and caspase evaluations of 1,6-diaryl-3(Z)-hexen-1,5-diynes, 2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines and their derivatives Fulltext Access 11 Pages 2005
Novel anellated pyrazoloquinolin-3-ones: synthesis and in vitro BZR activity Fulltext Access 11 Pages 2005
Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa Fulltext Access 11 Pages 2005
Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases Fulltext Access 11 Pages 2005