The Structure of an Inverting GH43 β-Xylosidase from Geobacillus stearothermophilus with its Substrate Reveals the Role of the Three Catalytic Residues Fulltext Access 13 Pages 2006
Stimulated Expression of mRNAs in Activated T Cells Depends on a Functional CRM1 Nuclear Export Pathway Fulltext Access 13 Pages 2006
Structural Insights into Enzyme–Substrate Interaction and Characterization of Enzymatic Intermediates of Organic Hydroperoxide Resistance Protein from Xylella fastidiosa Fulltext Access 13 Pages 2006
Structures of Ubiquitin Insertion Mutants Support Site-specific Reflex Response to Insertions Hypothesis Fulltext Access 13 Pages 2006
The First Holocomplex Structure of Ribonucleotide Reductase Gives New Insight into its Mechanism of Action Fulltext Access 13 Pages 2006
Structure–Stability–Activity Relationship in Covalently Cross-linked N-Carbamoyl d-Amino acid Amidohydrolase and N-Acylamino acid Racemase Fulltext Access 13 Pages 2006
Crystal Structures of SnoaL2 and AclR: Two Putative Hydroxylases in the Biosynthesis of Aromatic Polyketide Antibiotics Fulltext Access 13 Pages 2006
The N-terminal 12 Residue Long Peptide of HIV gp41 is the Minimal Peptide Sufficient to Induce Significant T-cell-like Membrane Destabilization in Vitro Fulltext Access 13 Pages 2006
The Exocyclic Amine at the RNase P Cleavage Site Contributes to Substrate Binding and Catalysis Fulltext Access 13 Pages 2006
GuHCl and NaCl-dependent Hydrogen Exchange in MerP Reveals a Well-defined Core with an Unusual Exchange Pattern Fulltext Access 13 Pages 2006
Computational Sampling of a Cryptic Drug Binding Site in a Protein Receptor: Explicit Solvent Molecular Dynamics and Inhibitor Docking to p38 MAP Kinase Fulltext Access 13 Pages 2006
The C-terminal TPR Domain of Tom70 Defines a Family of Mitochondrial Protein Import Receptors Found only in Animals and Fungi Fulltext Access 13 Pages 2006
Overexpression of Hepatitis C Virus NS5A Protein Induces Chromosome Instability via Mitotic Cell Cycle Dysregulation Fulltext Access 13 Pages 2006
X-ray Crystal Structures of Rabbit N-acetylglucosaminyltransferase I (GnT I) in Complex with Donor Substrate Analogues Fulltext Access 13 Pages 2006
Human Transcription Factors Contain a High Fraction of Intrinsically Disordered Regions Essential for Transcriptional Regulation Fulltext Access 13 Pages 2006
Evolutionarily Distinct Residues in the Uncoupling Protein UCP1 Are Essential for Its Characteristic Basal Proton Conductance Fulltext Access 13 Pages 2006
Structure of the N-terminal Domain of the FOP (FGFR1OP) Protein and Implications for its Dimerization and Centrosomal Localization Fulltext Access 13 Pages 2006
Insights into Cephamycin Biosynthesis: the Crystal Structure of CmcI from Streptomyces clavuligerus Fulltext Access 13 Pages 2006
Role of Structural and Dynamical Plasticity in Sin3: The Free PAH2 Domain is a Folded Module in mSin3B Fulltext Access 13 Pages 2006
Structural Studies of a Two-domain Chitinase from Streptomyces griseus HUT6037 Fulltext Access 13 Pages 2006
Specific Recognition of HIV TAR RNA by the dsRNA Binding Domains (dsRBD1–dsRBD2) of PKR Fulltext Access 13 Pages 2006
The Component Polypeptide Chains of Bovine Insulin Nucleate or Inhibit Aggregation of the Parent Protein in a Conformation-dependent Manner Fulltext Access 13 Pages 2006
Quantitative Actin Folding Reactions using Yeast CCT Purified via an Internal Tag in the CCT3/γ Subunit Fulltext Access 13 Pages 2006
A target on the move: Innate and adaptive immune escape strategies of hepatitis C virus Fulltext Access 13 Pages 2006
Pharmacology of current and promising nucleosides for the treatment of human immunodeficiency viruses Fulltext Access 13 Pages 2006
Molecular Basis for Nucleotide-binding Specificity: Role of the Exocyclic Amino Group “N2” in Recognition by a Guanylyl-ribonuclease Fulltext Access 13 Pages 2006
Nuclear Sequestration of β-Subunits by Rad and Rem is Controlled by 14-3-3 and Calmodulin and Reveals a Novel Mechanism for Ca2+ Channel Regulation Fulltext Access 13 Pages 2006
Three-dimensional Structure of a Double Apoptosome Formed by the Drosophila Apaf-1 Related Killer Fulltext Access 13 Pages 2006
Roles of N-terminal Pyroglutamate in Maintaining Structural Integrity and pKa Values of Catalytic Histidine Residues in Bullfrog Ribonuclease 3 Fulltext Access 13 Pages 2006
Differential Roles of PKC-θ in the Regulation of Intracellular Calcium Concentration in Primary T Cells Fulltext Access 13 Pages 2006
Intrinsically Disordered Loops Inserted into the Structural Domains of Human Proteins Fulltext Access 13 Pages 2006
Structural Studies of MFE-1: the 1.9 Å Crystal Structure of the Dehydrogenase Part of Rat Peroxisomal MFE-1 Fulltext Access 13 Pages 2006
Solution Structure of the NEAT (NEAr Transporter) Domain from IsdH/HarA: the Human Hemoglobin Receptor in Staphylococcus aureus Fulltext Access 13 Pages 2006
The Oxidation State of DJ-1 Regulates its Chaperone Activity Toward α-Synuclein Fulltext Access 13 Pages 2006
Crystal Structure of Bordetella pertussis BugD Solute Receptor Unveils the Basis of Ligand Binding in a New Family of Periplasmic Binding Proteins Fulltext Access 13 Pages 2006
A Structural Basis for the Role of Nucleotide Specifying Residues in Regulating the Oligomerization of the Rv1625c Adenylyl Cyclase from M. tuberculosis Fulltext Access 13 Pages 2006
Crystal Structure of Full Length Topoisomerase I from Thermotoga maritima Fulltext Access 13 Pages 2006
Identity Elements Required for Enzymatic Formation of N2,N2-dimethylguanosine from N2-monomethylated Derivative and its Possible Role in Avoiding Alternative Conformations in Archaeal tRNA Fulltext Access 13 Pages 2006
A New Solution Structure of ATP Synthase Subunit c from Thermophilic Bacillus PS3, Suggesting a Local Conformational Change for H+-Translocation Fulltext Access 13 Pages 2006
Crystal Structure of Human BACE2 in Complex with a Hydroxyethylamine Transition-state Inhibitor Fulltext Access 13 Pages 2006
Structural Evidence for Adaptive Ligand Binding of Glycolipid Transfer Protein Fulltext Access 13 Pages 2006
Gold Nanocluster Formation using Metallothionein: Mass Spectrometry and Electron Microscopy Fulltext Access 13 Pages 2006
Molecular Structure of a Novel Membrane Protease Specific for a Stomatin Homolog from the Hyperthermophilic Archaeon Pyrococcus horikoshii Fulltext Access 13 Pages 2006
A Rearranging Ligand Enables Allosteric Control of Catalytic Activity in Copper-containing Nitrite Reductase Fulltext Access 13 Pages 2006
The Structure of Bovine Complement Component 3 Reveals the Basis for Thioester Function Fulltext Access 13 Pages 2006
blm3-1 Is an Allele of UBP3, a Ubiquitin Protease that Appears to Act During Transcription of Damaged DNA Fulltext Access 13 Pages 2006
Suppression of HIV-1 Protease Inhibitor Resistance by Phosphonate-mediated Solvent Anchoring Fulltext Access 13 Pages 2006
Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI Fulltext Access 13 Pages 2006
Crystal Structure and Mechanism of Tripeptidyl Activity of Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis Fulltext Access 13 Pages 2006
A Tandem of SH3-like Domains Participates in RNA Binding in KIN17, a Human Protein Activated in Response to Genotoxics Fulltext Access 13 Pages 2006
SOS Repair and DNA Supercoiling Influence the Genetic Stability of DNA Triplet Repeats in Escherichia coli Fulltext Access 13 Pages 2006
Selective Binding of Meiosis-specific Yeast Hop1 Protein to the Holliday Junctions Distorts the DNA Structure and Its Implications for Junction Migration and Resolution Fulltext Access 13 Pages 2006
Structure of Leishmania mexicana Phosphomannomutase Highlights Similarities with Human Isoforms Fulltext Access 13 Pages 2006
NMR-based Model Reveals the Structural Determinants of Mammalian Arylamine N-Acetyltransferase Substrate Specificity Fulltext Access 13 Pages 2006
Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114 Fulltext Access 13 Pages 2006
PAS Domain Allostery and Light-induced Conformational Changes in Photoactive Yellow Protein upon I2 Intermediate Formation, Probed with Enhanced Hydrogen/Deuterium Exchange Mass Spectrometry Fulltext Access 13 Pages 2006
Xenobiotic Reductase A in the Degradation of Quinoline by Pseudomonas putida 86: Physiological Function, Structure and Mechanism of 8-Hydroxycoumarin Reduction Fulltext Access 13 Pages 2006
Discoidin Domain Receptor 2 Inhibits Fibrillogenesis of Collagen Type 1 Fulltext Access 13 Pages 2006
Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition Fulltext Access 13 Pages 2006
Translation Initiation Factor IF2 Interacts with the 30 S Ribosomal Subunit via Two Separate Binding Sites Fulltext Access 13 Pages 2006
Sequence Motifs and Antimotifs in β-Barrel Membrane Proteins from a Genome-Wide Analysis: The Ala-Tyr Dichotomy and Chaperone Binding Motifs Fulltext Access 13 Pages 2006
Engineering, Biophysical Characterisation and Binding Properties of a Soluble Mutant form of Annexin A2 Domain IV that Adopts a Partially Folded Conformation Fulltext Access 13 Pages 2006
Dcs2, a Novel Stress-induced Modulator of m7GpppX Pyrophosphatase Activity that Locates to P Bodies Fulltext Access 13 Pages 2006
Characterization of the Reactivity Determinants of a Novel Hairpin Substrate of Yeast RNase III Fulltext Access 13 Pages 2006
Natural Selection for Kinetic Stability Is a Likely Origin of Correlations between Mutational Effects on Protein Energetics and Frequencies of Amino Acid Occurrences in Sequence Alignments Fulltext Access 13 Pages 2006
Iron Incorporation in Streptococcus suis Dps-like Peroxide Resistance Protein Dpr Requires Mobility in the Ferroxidase Center and Leads to the Formation of a Ferrihydrite-like Core Fulltext Access 13 Pages 2006
Allosteric Communication Network in the Tetrameric Restriction Endonuclease Bse634I Fulltext Access 13 Pages 2006
PARP-1 Interaction with VP1 Capsid Protein Regulates Polyomavirus Early Gene Expression†† Fulltext Access 13 Pages 2006
The Alkali Molten Globule State of Horse Ferricytochrome c: Observation of Cold Denaturation Fulltext Access 13 Pages 2006
Crystal Structure of Escherichia coliL-Arabinose Isomerase (ECAI), The Putative Target of Biological Tagatose Production Fulltext Access 13 Pages 2006
Interplay Between Ion Binding and Catalysis in the Thioredoxin-coupled Arsenate Reductase Family Fulltext Access 13 Pages 2006
T-rich DNA Single Strands Bind to a Preformed Site on the Bacterial Cold Shock Protein Bs-CspB Fulltext Access 13 Pages 2006
Structural and Kinetic Analysis of Caspase-3 Reveals Role for S5 Binding Site in Substrate Recognition Fulltext Access 13 Pages 2006
Structure of a GDP:AlF4 Complex of the SRP GTPases Ffh and FtsY, and Identification of a Peripheral Nucleotide Interaction Site Fulltext Access 13 Pages 2006
Translocation of a tRNA with an Extended Anticodon Through the Ribosome Fulltext Access 13 Pages 2006
Structural Rearrangements in the Thyroid Hormone Receptor Hinge Domain and Their Putative Role in the Receptor Function Fulltext Access 13 Pages 2006
A Novel Glycoside Hydrolase Family 105: The Structure of Family 105 Unsaturated Rhamnogalacturonyl Hydrolase Complexed with a Disaccharide in Comparison with Family 88 Enzyme Complexed with the Disaccharide Fulltext Access 13 Pages 2006
Monitoring the Diffusion of Single Heterotrimeric G Proteins in Supported Cell-membrane Sheets Reveals their Partitioning into Microdomains Fulltext Access 13 Pages 2006
Evidence that Creation of Invasion Sites Determines the Rate of Strand Transfer Mediated by HIV-1 Reverse Transcriptase Fulltext Access 13 Pages 2006
Inmunogenicidad y eficacia protectora de la vacuna de la varicela atenuada y efectividad e impacto de la vacunación universal de la población infantil Fulltext Access 13 Pages 2006
Mechanism of Phosphoryl Transfer Catalyzed by Shikimate Kinase from Mycobacterium tuberculosis Fulltext Access 13 Pages 2006
Self-interaction of a SNARE Transmembrane Domain Promotes the Hemifusion-to-fusion Transition Fulltext Access 13 Pages 2006
Crystal Structures of Human NUDT5 Reveal Insights into the Structural Basis of the Substrate Specificity Fulltext Access 13 Pages 2006
Structural Tolerance versus Functional Intolerance to Mutation of Hydrophobic Core Residues Surrounding Cavities in a Parvovirus Capsid Fulltext Access 13 Pages 2006
Characterization of the Functional Domains of Escherichia coli RNase II Fulltext Access 13 Pages 2006
Simulations of the Myosin II Motor Reveal a Nucleotide-state Sensing Element that Controls the Recovery Stroke Fulltext Access 13 Pages 2006
Structural Classification and Prediction of Reentrant Regions in α-Helical Transmembrane Proteins: Application to Complete Genomes Fulltext Access 13 Pages 2006
Transcriptional Response of Candida albicans to Hypoxia: Linkage of Oxygen Sensing and Efg1p-regulatory Networks Fulltext Access 13 Pages 2006
Crystal Structure and Nucleotide Binding of the Thermus thermophilus RNA Helicase Hera N-terminal Domain Fulltext Access 13 Pages 2006
Amino-terminal Domain Stability Mediates Apolipoprotein E Aggregation into Neurotoxic Fibrils Fulltext Access 13 Pages 2006