Levetiracetam mitigates lipopolysaccharide-induced JAK2/STAT3 and TLR4/MAPK signaling pathways activation in a rat model of adjuvant- induced arthritis Fulltext Access 36 Pages 2018
Nimodipine attenuates tau phosphorylation at Ser396 via miR-132/GSK-3β pathway in chronic cerebral hypoperfusion rats Fulltext Access 36 Pages 2018
4-Hydroperoxy-2-decenoic acid ethyl ester protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways Fulltext Access 36 Pages 2018
Secoisolariciresinol diglucoside inhibits adipogenesis through the AMPK pathway Fulltext Access 36 Pages 2018
Deoxynucleosides with benzimidazoles as aglycone moiety are potent anticancer agents Fulltext Access 36 Pages 2018
Pharmacological inhibition of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation Fulltext Access 36 Pages 2018
CNS distribution, signalling properties and central effects of G-protein coupled receptor 4 Fulltext Access 36 Pages 2018
Phosphodiesterase-3 inhibitor cilostazol reverses endothelial dysfunction with ageing in rat mesenteric resistance arteries Fulltext Access 36 Pages 2018
A major component of vitamin E, α-tocopherol inhibits the anti-tumor activity of crizotinib against cells transformed by EML4-ALK Fulltext Access 36 Pages 2018
Impact on GABA systems in monogenetic developmental CNS disorders: Clues to symptomatic treatment Fulltext Access 36 Pages 2018
Transient global cerebral ischemia differentially affects cortex, striatum and hippocampus in Bilateral Common Carotid Arterial occlusion (BCCAo) mouse model Fulltext Access 36 Pages 2018
S1P promotes migration, differentiation and immune regulatory activity in amniotic-fluid-derived stem cells Fulltext Access 36 Pages 2018
Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT Fulltext Access 36 Pages 2018
An optimized dose of raspberry ketones controls hyperlipidemia and insulin resistance in male obese rats: Effect on adipose tissue expression of adipocytokines and Aquaporin 7 Fulltext Access 36 Pages 2018
Chronic morphine selectively sensitizes the effect of D1 receptor agonist on presynaptic glutamate release in basolateral amygdala neurons that project to prelimbic cortex Fulltext Access 36 Pages 2018
Effects of trans-resveratrol on type 1 diabetes-induced inhibition of retinoic acid metabolism pathway in retinal pigment epithelium of Dark Agouti rats Fulltext Access 36 Pages 2018
Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3 Fulltext Access 36 Pages 2018
Vaspin protects rats against myocardial ischemia/reperfusion injury (MIRI) through the TLR4/NF-κB signaling pathway Fulltext Access 36 Pages 2018
Calcium-activated SK potassium channels are key modulators of the pacemaker frequency in locus coeruleus neurons Fulltext Access 36 Pages 2018
Apremilast prevent doxorubicin-induced apoptosis and inflammation in heart through inhibition of oxidative stress mediated activation of NF-κB signaling pathways Fulltext Access 36 Pages 2018
Peptide welding technology - A simple strategy for generating innovative ligands for G protein coupled receptors Fulltext Access 36 Pages 2018
An improved measurement of the Ca2+-binding affinity of fluorescent Ca2+ indicators Fulltext Access 36 Pages 2018
Remote limb ischemic postconditioning protects against cerebral ischemia-reperfusion injury by activating AMPK-dependent autophagy Fulltext Access 36 Pages 2018
Pattern recognition receptors mediate pro-inflammatory effects of extracellular mitochondrial transcription factor A (TFAM) Fulltext Access 36 Pages 2018
Ghrelin suppresses cardiac fibrosis of post-myocardial infarction heart failure rats by adjusting the activin A-follistatin imbalance Fulltext Access 36 Pages 2018
Effective suppression of donor specific antibody production by Cathepsin S inhibitors in a mouse transplantation model Fulltext Access 36 Pages 2018
Quinolinic acid and glutamatergic neurodegeneration in Caenorhabditis elegans Fulltext Access 36 Pages 2018
Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation: Role of α7 nicotinic receptor, glutamate and oxidative stress Fulltext Access 36 Pages 2018
Application of the gene editing tool, CRISPR-Cas9, for treating neurodegenerative diseases Fulltext Access 36 Pages 2018
Calcium uptake and cytochrome c release from normal and ischemic brain mitochondria Fulltext Access 36 Pages 2018
Osteoprotective effects of salidroside in ovariectomized mice and diabetic mice Fulltext Access 36 Pages 2018
Protein kinases are involved in the cardioprotective effects activated by platelet glycoprotein IIb/IIIa inhibitor tirofiban at reperfusion in rats in vivo Fulltext Access 37 Pages 2018
Modulation of tetrodotoxin-resistant Na+ channels by amitriptyline in dural afferent neurons Fulltext Access 37 Pages 2018
Paeoniflorin regulates GALNT2-ANGPTL3-LPL pathway to attenuate dyslipidemia in mice Fulltext Access 37 Pages 2018
3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases Fulltext Access 37 Pages 2018
Interferon-stimulated gene 15 promotes cholesterol efflux by activating autophagy via the miR-17-5p/Beclin-1 pathway in THP-1 macrophage-derived foam cells Fulltext Access 37 Pages 2018
Roles of CSGalNAcT1, a key enzyme in regulation of CS synthesis, in neuronal regeneration and plasticity Fulltext Access 37 Pages 2018
Efficacy of constant long-term delivery of YM-58483 for the treatment of rheumatoid arthritis Fulltext Access 37 Pages 2018
Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity Fulltext Access 37 Pages 2018
Antiallodynic and antihyperalgesic activity of new 3,3-diphenyl-propionamides with anticonvulsant activity in models of pain in mice Fulltext Access 37 Pages 2018
17β-estradiol suppresses carboxylesterases by activating c-Jun/AP-1 pathway in primary human and mouse hepatocytes Fulltext Access 37 Pages 2018
Cell- and stage-specific localization of galectin-3, a β-galactoside-binding lectin, in a mouse model of experimental autoimmune encephalomyelitis Fulltext Access 37 Pages 2018
Neuroendocrine response to GABA-B receptor agonism in alcohol-dependent individuals: Results from a combined outpatient and human laboratory experiment Fulltext Access 37 Pages 2018
Anti-β2GPI/β2GPI induces neutrophil extracellular traps formation to promote thrombogenesis via the TLR4/MyD88/MAPKs axis activation Fulltext Access 37 Pages 2018
Identification and expression of carbonic anhydrase 2, myosin regulatory light chain 2 and selenium-binding protein 1 in zebrafish Danio rerio: Implication for age-related biomarkers Fulltext Access 37 Pages 2018
Differential distribution and function of GABABRs in somato-dendritic and axonal compartments of principal cells and interneurons in cortical circuits Fulltext Access 37 Pages 2018
Under stressful conditions activation of the ionotropic P2X7 receptor differentially regulates GABA and glutamate release from nerve terminals of the rat cerebral cortex Fulltext Access 37 Pages 2018
Activation of 5-HT2C (but not 5-HT1A) receptors in the amygdala enhances fear-induced antinociception: Blockade with local 5-HT2C antagonist or systemic fluoxetine Fulltext Access 37 Pages 2018
Kaempferol-induces vasorelaxation via endothelium-independent pathways in rat isolated pulmonary artery Fulltext Access 37 Pages 2018
Astrocytic γ-aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain Fulltext Access 37 Pages 2018
Antidepressant-like effects of a novel curcumin derivative J147: Involvement of 5-HT1A receptor Fulltext Access 37 Pages 2018
Distribution of MCH-containing fibers in the feline brainstem: Relevance for REM sleep regulation Fulltext Access 37 Pages 2018
Human dihydrolipoamide dehydrogenase (E3) deficiency: Novel insights into the structural basis and molecular pathomechanism Fulltext Access 37 Pages 2018
An insurmountable NPY Y5 receptor antagonist exhibits superior anti-obesity effects in high-fat diet-induced obese mice Fulltext Access 38 Pages 2018
Capsaicin prevents mitochondrial damage, protects cardiomyocytes subjected to anoxia/reoxygenation injury mediated by 14-3-3η/Bcl-2 Fulltext Access 38 Pages 2018
Cardiovascular responses to intranasal neuropeptide Y in single prolonged stress rodent model of post-traumatic stress disorder Fulltext Access 38 Pages 2018
The role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions Fulltext Access 38 Pages 2018
The memory-enhancing effects of 7,8,4'-trihydroxyisoflavone, a major metabolite of daidzein, are associated with activation of the cholinergic system and BDNF signaling pathway in mice Fulltext Access 38 Pages 2018
Role of PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats Fulltext Access 38 Pages 2018
Long noncoding RNA DANCR mediates cisplatin resistance in glioma cells via activating AXL/PI3K/Akt/NF-κB signaling pathway Fulltext Access 38 Pages 2018
Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5 Fulltext Access 38 Pages 2018
Ethanol differentially modulates P2X4 and P2X7 receptor activity and function in BV2 microglial cells Fulltext Access 38 Pages 2018
Fasudil ameliorates the ischemia/reperfusion oxidative injury in rat hearts through suppression of myosin regulatory light chain/NADPH oxidase 2 pathway Fulltext Access 38 Pages 2018
iTRAQ-based differential proteomic analysis of the brains in a rat model of delayedcarbon monoxide encephalopathy Fulltext Access 38 Pages 2018
Morphogenetic movements affect local tissue organisation during embryonic Drosophila morphogenesis Fulltext Access 38 Pages 2018
TIGAR inhibits ischemia/reperfusion-induced inflammatory response of astrocytes Fulltext Access 38 Pages 2018
Diverse signalling of the platelet P2Y1 receptor leads to a dichotomy in platelet function Fulltext Access 38 Pages 2018
Tetramethylpyrazine attenuates lipopolysaccharide-induced cardiomyocyte injury via improving mitochondrial function mediated by 14-3-3γ Fulltext Access 38 Pages 2018
Effects of AS2541019, a novel selective PI3Kδ inhibitor, on antibody production and hamster to rat xenotransplantation Fulltext Access 38 Pages 2018
Quantitative expression and localization of GABAB receptor protein subunits in hippocampi from patients with refractory temporal lobe epilepsy Fulltext Access 38 Pages 2018
Inhibition of protein tyrosine phosphatase 1B in spinal cord dorsal horn of rats attenuated diabetic neuropathic pain Fulltext Access 38 Pages 2018
Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice Fulltext Access 38 Pages 2018
Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death Fulltext Access 38 Pages 2018
Effect of polygodial and its direct derivatives on the mammalian Na+/K+-ATPase activity Fulltext Access 38 Pages 2018
Transcriptomic changes in C2C12 myotubes triggered by electrical stimulation: Role of Ca2+i-mediated and Ca2+i-independent signaling and elevated [Na+]i/[K+]i ratio Fulltext Access 39 Pages 2018
A novel highly potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, INU-101 Fulltext Access 39 Pages 2018
Disrupting interaction of PSD-95 with nNOS attenuates hemorrhage-induced thalamic pain Fulltext Access 39 Pages 2018
Repeated olanzapine treatment mitigates PTSD like symptoms in rats with changes in cell signaling factors Fulltext Access 39 Pages 2018
Suppression of NLRP3 attenuates hemorrhagic transformation after delayed rtPA treatment in thromboembolic stroke rats: Involvement of neutrophil recruitment Fulltext Access 39 Pages 2018
Photoreceptor calcium sensor proteins in detergent-resistant membrane rafts are regulated via binding to caveolin-1 Fulltext Access 39 Pages 2018
Basolateral amygdala noradrenergic activity is required for enhancement of object recognition memory by histone deacetylase inhibition in the anterior insular cortex Fulltext Access 39 Pages 2018
Prostaglandin D2 generation from human lung mast cells is catalysed exclusively by cyclooxygenase-1 Fulltext Access 39 Pages 2018
SIRT5 and post-translational protein modifications: A potential therapeutic target for myocardial ischemia-reperfusion injury with regard to mitochondrial dynamics and oxidative metabolism Fulltext Access 39 Pages 2018
Distinctive binding properties of the negative allosteric modulator, [3H]SB269,652, at recombinant dopamine D3 receptors Fulltext Access 39 Pages 2018
Abnormalities in behaviour, histology and prefrontal cortical gene expression profiles relevant to schizophrenia in embryonic day 17 MAM-Exposed C57BL/6 mice Fulltext Access 39 Pages 2018
In vivo and in vitro ADMET profiling and in vivo pharmacodynamic investigations of a selective α7 nicotinic acetylcholine receptor agonist with a spirocyclic Î2-isoxazoline molecular skeleton Fulltext Access 39 Pages 2018
Activation of axon initial segmental GABAA receptors inhibits action potential generation in neocortical GABAergic interneurons Fulltext Access 39 Pages 2018
PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy Fulltext Access 39 Pages 2018
A novel harmine derivative, N-(4-(hydroxycarbamoyl)benzyl)-1-(4- methoxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxamide (HBC), as histone deacetylase inhibitor: in vitro antiproliferation, apoptosis induction, cell cycle arrest, and antimetastatic effects Fulltext Access 39 Pages 2018
A novel HDAC6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer Fulltext Access 39 Pages 2018
Suppression of Akt-mediated HDAC3 expression and CDK2 T39 phosphorylation by a bichalcone analog contributes to S phase retardation of cancer cells Fulltext Access 39 Pages 2018
Antidepressant-like actions by silencing of neuronal ELAV-like RNA-binding proteins HuB and HuC in a model of depression in male mice Fulltext Access 39 Pages 2018
The metabotropic glutamate receptor 5 radioligand [11C]AZD9272 identifies unique binding sites in primate brain Fulltext Access 39 Pages 2018
Direct evidence for high affinity blockade of NaV1.6 channel subtype by huwentoxin-IV spider peptide, using multiscale functional approaches Fulltext Access 39 Pages 2018
SLOH, a carbazole-based fluorophore, mitigates neuropathology and behavioral impairment in the triple-transgenic mouse model of Alzheimer's disease Fulltext Access 39 Pages 2018