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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

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Fulltext Access 7 Pages 2006
Synthesis of 1′-fluorouracil nucleosides as potential antimetabolites
Fulltext Access 7 Pages 2006
Stereo-recognizing transformation of (E)-alkenyl halides into sulfides catalyzed by nickel(0) triethyl phosphite complex
Fulltext Access 7 Pages 2006
Total synthesis and reassignment of stereochemistry of obyanamide
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An asymmetric aminohydroxylation route to cis-2,6-disubstituted piperidine-3-ol: application to the synthesis of (−)-deoxocassine
Fulltext Access 7 Pages 2006
Graphical contents list
Fulltext Access 7 Pages 2006
Cyclization versus oligomerization of SP- and RP-5′-OH-N4-benzoyl-2′-deoxycytidine-3′-O-(2-thio-4,4-pentamethylene-1,3,2-oxathiaphospholane)s
Fulltext Access 7 Pages 2006
Synthesis of 1,2,4-triazole dendrimers
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Substituent effect on anthracene-based bisboronic acid glucose sensors
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Rapid solution and solid phase synthesis of monodisperse oligo[(1,4-phenyleneethynylene)-alt-(2,5-thiopheneethynylene)]s
Fulltext Access 7 Pages 2006
Psoracorylifols A-E, five novel compounds with activity against Helicobacter pylori from seeds of Psoralea corylifolia
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Alkaline hydrolysis of N-bromoiminothianthrene derivatives
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A versatile route to the synthesis of 1-substituted β-carbolines by a single step Pictet-Spengler cyclization
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A new class of chiral tetrahydropyran-4-one catalyst for asymmetric epoxidation of alkenes
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Chemoselective ring closure of thiacalix[4]arene-1,3-bis(N-ω-hydroxyalkylamides) via the Mitsunobu reaction
Fulltext Access 7 Pages 2006
Reactions of (E)-1,2-di(3-guaiazulenyl)ethylene and 2-(3-guaiazulenyl)-1,1-bis(4-methoxyphenyl)ethylene with tetracyanoethylene (TCNE) in benzene: comparative studies on the products and their spectroscopic properties
Fulltext Access 7 Pages 2006
A novel ruthenium(II) tris(bipyridine)-zinc porphyrin-rhenium carbonyl triad: synthesis and optical properties
Fulltext Access 7 Pages 2006
1,3-Dimethyl-2-(3-nitro-1,2,4-triazol-1-yl)-2-pyrrolidin-1-yl-1,3,2-diazaphospholidinium hexafluorophosphate (MNTP): a powerful condensing reagent for phosphate and phosphonate esters
Fulltext Access 7 Pages 2006
Haval-Argade contrathermodynamic rearrangement of alkylidenesuccinimides to alkylmaleimides via the corresponding isoimides: a general approach to alkyl and dialkyl substituted maleimides
Fulltext Access 7 Pages 2006
Synthesis of 5,8-dimethoxynaphtho[2,3-c]furan-4(9H)-one
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Synthesis of tetrathiafulvalene-annulated phthalocyanines
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Seragamides A-F, new actin-targeting depsipeptides from the sponge Suberites japonicus Thiele
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Chemoenzymatic resolution of epimeric cis 3-carboxycyclopentylglycine derivatives
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Externally sensitized mesolytic fragmentations in dithiane-ketone adducts
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Annulated heterocycles through a radical-cation cyclization: synthetic and mechanistic studies
Fulltext Access 7 Pages 2006
Preparation and reactions of 3-phosphinyl-1-aza-1,3-butadienes. Synthesis of phosphorylated pyridine and pyrazole derivatives
Fulltext Access 7 Pages 2006
Graphical contents list
Fulltext Access 7 Pages 2006
Toward aflatoxin B2: an unexpected additive effect in a Dötz benzannulation reaction
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Development in synthesis and electrochemical properties of thienyl derivatives of carbazole
Fulltext Access 7 Pages 2006
Palladium catalyzed synthesis of Ca2+ indicators with aryl bithiophene and terthiophene fluorophores
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Amarantholidols and amarantholidosides: new nerolidol derivatives from the weed Amaranthus retroflexus
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Clean and selective oxidation of alcohols catalyzed by ion-supported TEMPO in water
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Study on the reactions of fluoroalkanesulfonyl azides with cycloalkenyl ether and aryl ynamines
Fulltext Access 7 Pages 2006
Uncatalyzed solventless Diels-Alder reaction of 2-amino-3-nitroacrylate: synthesis of new epimeric 2-amino-3-nitro-norbornene- and norbornane-2-carboxylic acids
Fulltext Access 7 Pages 2006
Synthesis and characterization of a novel electrical and optical-active triads containing fullerene and perylenebisimide units
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Revisiting the Corey-Chaykovsky reaction: the solvent effect and the formation of β-hydroxy methylthioethers
Fulltext Access 7 Pages 2006
One-pot synthesis of fluorinated 2-amino-pyrimidine-N-oxides. Competing pathways in the four-atom side-chain rearrangements of 1,2,4-oxadiazoles
Fulltext Access 7 Pages 2006
New strategy towards the efficient solid phase synthesis of cyclopeptides
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Distannane mediated reaction of N-acyliminium ion pools with alkyl halides. A chain mechanism involving radical addition followed by electron transfer
Fulltext Access 7 Pages 2006
Formation of polysubstituted chlorocyclopropanes from electrophilic olefins and activated trichloromethyl compounds
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Regioselectivity in arene-catalyzed reductive lithiation of acetals of chlorobenzaldehydes
Fulltext Access 7 Pages 2006
Reactions of (1R,2S)-1,2-di(2-furyl)-1,2-di(3-guaiazulenyl)ethane and (1R,2S)-1,2-di(3-guaiazulenyl)-1,2-di(2-thienyl)ethane with tetracyanoethylene (TCNE) in benzene: comparative studies on the products and their spectroscopic properties
Fulltext Access 7 Pages 2006
Photooxygenations of 1-naphthols: an environmentally friendly access to 1,4-naphthoquinones
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Zinc perchlorate catalyzed one-pot amination-annulation of α-cyanomethyl-β-ketoesters in water. Regioselective synthesis of 2-aminopyrrole-4-carboxylates
Fulltext Access 7 Pages 2006
A straightforward synthesis and structure of unprecedented iminium salts of dihydropyrido[3,2-e][1,3]thiazines
Fulltext Access 7 Pages 2006
Graphical contents list
Fulltext Access 7 Pages 2006
Planned and unplanned halogenations in route to selected oroidin alkaloids
Fulltext Access 7 Pages 2006
Highly selective formation of propargyl- and allenyltrichlorosilanes and their regiospecific addition to various types of aldehydes: preparation of both allenic and homopropargylic alcohols
Fulltext Access 7 Pages 2006
A Practical, efficient, and atom economic alternative to the Wittig and Horner-Wadsworth-Emmons reactions for the synthesis of (E)-α,β-unsaturated esters from aldehydes
Fulltext Access 7 Pages 2006
Rapid, room-temperature acylative kinetic resolution of sec-alcohols using atropisomeric 4-aminopyridine/triphenylphosphine catalysis
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Non-optical screening platforms: the next wave in label-free screening?
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Immunomics: discovering new targets for vaccines and therapeutics
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Cell microarrays in drug discovery
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An overview of statin-associated proteinuria
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Computational modeling of biologically active molecules using NMR spectra
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Bone morphogenetic proteins and growth differentiation factors as drug targets in cardiovascular and metabolic disease
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Selectins – potential pharmacological targets?
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Solubility: it's not just for physical chemists
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Ischemic acute tubular necrosis models and drug discovery: a focus on cellular inflammation
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Similarity in drugs: reflections on analogue design
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Food for thought
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Therapeutic potential of interfering with apelin signalling
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Imaging Alzheimer's disease pathology: one target, many ligands
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Dual-action peptides: a new strategy in the treatment of diabetes-associated neuropathy
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Optical biosensors: where next and how soon?
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Novel fluorescent proteins for high-content screening
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A delayed prey-predator system with parasitic infection
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The origin of spontaneous synchronized burst in cultured neuronal networks based on multi-electrode arrays
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Factors influencing synonymous codon and amino acid usage biases in Mimivirus
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New species in evolving networks—stochastic theory of sensitive networks and applications on the metaphorical level
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Adaptability and the integration of computer-based information processing into the dynamics of organizations
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Forming and maintaining a heat engine for quantum biology
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From electric patterns to drugs: Perspectives of computational neuroscience in drug design
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Analysis of the oscillatory kinetics of glycolytic intermediates in a yeast extract by FT-IR spectroscopy
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Metabolic homeostasis in the human erythrocyte: In silico analysis
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New tools and approaches for predicting skin permeability
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The interaction of solvatochromic pyridiniophenolates with cyclodextrins
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Phosphonylated thiocarbonyl ylides from the reaction of aromatic thioketones with diethyl diazomethylphosphonates
Fulltext Access 7 Pages 2006
Novel tandem reactions of ethyl acetoacetate with aromatic aldehydes: product- and stereo-selective formation of highly functionalised cyclohexanones
Fulltext Access 7 Pages 2006
Microwave-assisted efficient synthesis of 1,2-diaryldiketones: a novel oxidation reaction of diarylalkynes with DMSO promoted by FeBr3
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Cell penetrating silica nanoparticles doped with two-photon absorbing fluorophores
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Stereochemical challenges in characterizing nitrogenous spiro-axane sesquiterpenes from the Indo-Pacific sponges Amorphinopsis and Axinyssa
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Synthesis of aza-analogues of Ganciclovir
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New insights into the molecular pathogenesis of colorectal cancer
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New development in the mechanistic understanding of peptic ulcer diseases
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Mitochondrial complex III deficiencies in the newborn infant
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HTS technologies in biopharmaceutical discovery
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Heat shock proteins as vaccine adjuvants in infections and cancer
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Using a mammalian cell cycle simulation to interpret differential kinase inhibition in anti-tumour pharmaceutical development
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Modern agrochemical research: a missed opportunity for drug discovery?
Fulltext Access 7 Pages 2006
Exploiting the enhanced permeability and retention effect for tumor targeting
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Cytomics as a new potential for drug discovery
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Regulating biopharmaceuticals under CDER versus CBER: an insider's perspective
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Canonical transient receptor potential channels in disease: targets for novel drug therapy?
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The therapeutic potential of the calpain family: new aspects
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Human glial cell culture models of inflammation in the central nervous system
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Harnessing in vivo siRNA delivery for drug discovery and therapeutic development
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Airborne infectious disease and the suppression of pulmonary bioaerosols
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The potential impact of structural genomics on tuberculosis drug discovery
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New drug candidates and therapeutic targets for tuberculosis therapy
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