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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Construction of furo[3,4-c]pyran skeleton starting from the Baylis-Hillman adducts via the ring-closing metathesis (RCM) reaction of exo-methylene tetrahydrofuran
Fulltext Access 7 Pages 2006
Synthesis and new rearrangements of 4-isoxazolin-4,5-dicarboxylic acid derivatives
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Synthesis and tautomerism study of 7-substituted pyrazolo[3,4-c]pyridines
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4,4′-Substituted biphenyl coronands. Preparation of a new selective fluorescent sensor for mercury salts
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Preparation of non-racemic single-stereocentre α-aminonitriles and a study of their fate in Bruylants reactions
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Factors affecting the efficiency and stereoselectivity of α-amino acid synthesis by the Petasis reaction
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Synthesis, structural determination and photo-antiproliferative activity of new 3-pyrazolyl or -isoxazolyl substituted 4-hydroxy-2(1H)-quinolinones
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Synthesis of methyl sulfomycinate, sulfomycinic amide and sulfomycinine, degradation products of the sulfomycin thiopeptide antibiotics
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Graphical contents list
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Vinylic nucleophilic substitution in functionalized 2-vinylpyrroles: a route to a new family of stable enols
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Reactions of acceptor substituted thiophene-1,1-dioxides with cyclopentadiene: control of selectivity by substitution
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(R)-4-Hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate: chiral building block for the synthesis of optically active α-substituted α-amino acid derivatives
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Antiparasite and antimycobacterial activity of passifloricin analogues
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Synthesis and isomerization of N-α-aza-heteroaryl-β-lactams
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A general and efficient synthesis of 3,6-diazabicyclo[3.2.1]octanes
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Expeditious synthesis of sulfoazetidine spiro-C-glycosides from ketose acetals
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Synthesis of Fréchet type dendritic benzyl propargyl ether and Fréchet type triazole dendrimer
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Diastereoselective allylation of α-ketoamides bearing camphor N-tosylpyrazolidinone auxiliary: efficient synthesis of highly optically active two stereoisomers
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4-Formylazetidin-2-ones, synthon for the synthesis of (2R,3S) and (2S,3R)-3-amino-2-hydroxydecanoic acid (AHDA)
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Direct determination of the stereoisomer constitution by 2D-HPLC and stereochemistry-pheromone activity relationship of the copulation release pheromone of the cowpea weevil, Callosobruchus maculatus
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Efficient synthesis of antisense phosphorothioate oligonucleotides using a universal solid support
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π-Relaxation of the ring strain: design of polycyclic unsaturated silicon molecules
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Tetrathiafulvalene-based podands bearing one or two thiol functions: immobilization as self-assembled monolayers or polymer films, and recognition properties
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Facile solid-phase synthesis of 2,3-disubstituted 6H-pyrano[2,3-f]benzimidazole-6-ones
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Synthesis of functionalized 3-spirocyclopropane-2-indolones from isomerised Baylis-Hillman adducts of isatin
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Unusual sesquiterpene glucosides from Amaranthus retroflexus
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Graphical contents list
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Graphical contents list
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Catalyst economy. Part 2: Sequential metathesis-Kharasch sequences using the Grubbs metathesis catalysts
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Graphical contents list
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Ligand effects in aluminium-catalyzed asymmetric Baeyer-Villiger reactions
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Efficient chemoselective alcohol oxidation using oxygen as oxidant. Superior performance of gold over palladium catalysts
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Comparison of TEMPO and its derivatives as mediators in laccase catalysed oxidation of alcohols
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Bicyclo[3.2.1]octanone catalysts for asymmetric alkene epoxidation: the effect of disubstitution
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Non-aqueous iminium salt mediated catalytic asymmetric epoxidation
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Synthesis and photochromic reactivity of diarylethene trimers bridged by ethenyl and ethynyl unit
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Preparation of N-arylpiperazines and other N-aryl compounds from aryl bromides as scaffolds of bioactive compounds
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Stereoselective syntheses of (−)-chloramphenicol and (+)-thiamphenicol
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Convenient preparation of substituted 5-aminooxazoles via a microwave-assisted Cornforth rearrangement
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Graphical contents list
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A novel tert-amino effect based approach to 1,2,3,4-tetrahydroquinoline-2-spirocycloalkanes
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Graphical contents list
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Radical mediated stereoselective synthesis of (4R,8R)-4,8-dimethyldecanal, an aggregation pheromone of Tribolium flour beetles
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Synthesis and complexation studies of intra annularly linked bicyclic cyclophanes
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Synthesis of 7-hydroxy-6H-benzo[c]chromen-6-ones based on a '[3+3] cyclization/domino retro-Michael-aldol-lactonization' strategy
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Gallic esters of 4,5-dinitrocatechol as potential building blocks for thermotropic liquid crystals
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Synthesis of (S)-gizzerosine, a potent inducer of gizzard erosion in chicks
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Nanostaircase formation in the solid state from self-assembling synthetic terephthalamides with a common molecular scaffold
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Synthesis of large generation poly(propyl ether imine) (PETIM) dendrimers
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Achieving saturated red photoluminescence and electroluminescence with readily synthesized maleimide-arylamine copolymers
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Oxazoline Chemistry. Part 11: Syntheses of natural and synthetic isoflavones, stilbenes and related species via C-C bond formation promoted by a Pd-oxazoline complex
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Cobalt-catalyzed cross-coupling reactions of alkyl halides with aryl Grignard reagents and their application to sequential radical cyclization/cross-coupling reactions
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Malonganenones A-C, novel tetraprenylated alkaloids from the Mozambique gorgonian Leptogorgia gilchristi
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Synthesis of thiazole aminophosphine oxides, aminophosphonic and aminophosphinic acids and Cu(II) binding abilities of thiazole aminophosphonic acids
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N-Biphenyl thioureas as carboxylate receptors. Effect of the ligand substituents on the geometry of the complexes
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Stilbene like carbazole dimer-based electroluminescent materials
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Two-photon absorption chromophores with a tunable [2,2′]bithiophene core
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Synthesis of fluorhydrins by reaction of quinidine acetate, epiquinidine, and its acetate in superacid
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A convergent route to poly(phenyl ketone ether) dendrons
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A reinvestigated mechanism of ribosylation of adenine under silylating conditions
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Multi-state molecular switches based on dithienylperfluorocyclopentene and imidazo [4,5-f] [1,10] phenanthroline
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Evaluation of a simple and novel fluorescent anion sensor, 4-quinolone, and modification of the emission color by substitutions based on molecular orbital calculations
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Parallel synthesis of an indole-based library via an iterative Mannich reaction sequence
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Stereoselective synthesis of Sch 642305, an inhibitor of bacterial DNA primase
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Synthesis of conjugated 2,7-bis(trimethylsilylethynyl)-(phenylethynyl)nfluoren-9-one and 9-(p-methoxyphenyl)-9-methyl derivatives: optical properties
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Structural elucidation and bioactivity of novel secondary metabolites from Carex distachya
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An improved procedure for the preparation of the β-hydroxy-α-alkyl fatty acid fragment of mycolic acids
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A selective colorimetric chemosensor for lanthanide ions
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Highly specific N-monomethylation of primary aromatic amines
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Stereoselective carbonyl reductions of chloro-substituted 8-oxabicyclo[3.2.1]oct-6-en-3-ones
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Syriacin, a novel unusual sulfated ceramide glycoside from the freshwater sponge Ephydatia syriaca (Porifera, Demospongiae, Spongillidae)
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Superacid-catalyzed reactions of pyridinecarboxaldehydes
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Microwave assisted synthesis and crystal structures of 2-imidazolines and imidazoles
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Development of highly fluorescent photochromic material with high fatigue resistance
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Synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by copper-catalyzed cycloaddition-coupling of azides and terminal alkynes
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Graphical contents list
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A synthesis of novel N-sulfonylated β-amino acids
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1-Phenylthio-3-vinyl-3-cyclohexenol, a new reagent for bis-annelation of silyl enol ethers
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Theoretical study of the regioselectivity of the cycloaddition reaction between cyclopentadiene and methyleneketene
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Synthesis of substituted 5-aminomethyl tetrahydro-isoquinolines and dihydro-isoindoles
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Convenient syntheses of metabolically important quercetin glucuronides and sulfates
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Stereochemistry of the intermediates in the synthesis of 1,4,7,10-tetraazacyclododecane from triethylenetetramine, glyoxal and diethyl oxalate
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HSAB-driven chemoselective N1-alkylation of pyrimidine bases and their 4-methoxy- or 4-acetylamino-derivatives
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Highly efficient and selective oxidation of secondary alcohols to ketones under organic solvent and transition metal free conditions
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Total synthesis of prolycopene, a novel 7,9,7′,9′-tetra-cis(Z) carotenoid and main pigment of the tangerine tomato Lycopersicon esculentum
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Syntheses of enantio-enriched chiral building blocks from l-glutamic acid
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Kinetic resolution of poly(ethylene glycol)-supported carbonates by enzymatic hydrolysis
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Ceric Ammonium Nitrate (CAN) catalyzes the one-pot synthesis of polyhydroquinoline via the Hantzsch reaction
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Access to substituted thiapyrrolizidinones and fused pyridones using the domino N-acyliminium-thionium equilibrium/1,3-dipolar cycloaddition/desulfurization cyclization cascade
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Alkyne hydrosilylation catalyzed by nickel complexes of N-heterocyclic carbenes
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Two-carbon ring expansion of cyclobutanone skeletons by nickel-catalyzed intermolecular alkyne insertion
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New reactions and step economy: the total synthesis of (±)-salsolene oxide based on the type II transition metal-catalyzed intramolecular [4+4] cycloaddition
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Synthesis and stability of 1,1-dialkyl-1H-azulenium cations
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Synthesis of substituted 2,3,5,6,7,8-hexahydropyrazolo[4,3-d][1,2]diazepine-8-carboxylates
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Synthesis of 1,2-dihydro-4H-3,1-benzoxazine derivatives via ZnCl2 catalyzed cyclocondensation reaction
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Graphical contents list
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Greenish metal-lustrous organic crystals formed from 1-aryl-2-(2-thienyl)-5-(5-tricyanoethenyl-2-furyl)pyrroles
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Enantioselective diethylzinc addition to aromatic and aliphatic aldehydes using (3R,5R)-dihydroxypiperidine derivatives catalyst
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Brønsted acidity of ceric ammonium nitrate in anhydrous DMF. The role of salt and solvent in sucrose cleavage
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Synthesis of conformationally restricted nicotine analogues by intramolecular [3+2] cycloaddition
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