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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

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Fulltext Access 7 Pages 2006
A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity
Fulltext Access 7 Pages 2006
5-Substituted-2,3-diphenyltetrahydrofurans: A new class of moderately selective COX-2 inhibitors
Fulltext Access 7 Pages 2006
Influence of terminal branching on the transdermal permeation-enhancing activity in fatty alcohols and acids
Fulltext Access 7 Pages 2006
A Raman-active competitive inhibitor of OMP decarboxylase
Fulltext Access 7 Pages 2006
Lipase-catalyzed resolution of chiral 1,3-amino alcohols: application in the asymmetric synthesis of (S)-dapoxetine
Fulltext Access 7 Pages 2006
Influence of Lewis acids on the [4+2] cycloaddition of (2R,2′R)-N,N′-fumaroylbis[fenchane-8,2-sultam] to cyclopentadiene and cyclohexadiene
Fulltext Access 7 Pages 2006
Versatile building blocks from disaccharides: glycosylated 5-hydroxymethylfurfurals
Fulltext Access 7 Pages 2006
PmHNL catalyzed synthesis of (R)-cyanohydrins derived from aliphatic aldehydes
Fulltext Access 7 Pages 2006
Graphical contents list
Fulltext Access 7 Pages 2006
Salicylaldehyde Schiff bases derived from 2-ferrocenyl-2-amino alcohols. Part 2: Stereochemical divergence in the titanium-promoted enantioselective diketene addition to benzaldehyde
Fulltext Access 7 Pages 2006
Synthesis of (+)- and (−)-dihydropinidine by diastereoselective dimethylzinc promoted allylation of 2-methyltetrahydropyridine-N-oxide with an allylboronic ester
Fulltext Access 7 Pages 2006
Interaction of chiral bis-distamycin derivatives with DNAs: electronic circular dichroism study
Fulltext Access 7 Pages 2006
Computational evidence for the ligand selectivity to the α4β2 and α3β4 nicotinic acetylcholine receptors
Fulltext Access 7 Pages 2006
Efficient dynamic kinetic resolution of secondary alcohols with a novel tetrafluorosuccinato ruthenium complex
Fulltext Access 7 Pages 2006
Chemoenzymatic synthesis of optically active γ-alkyl-γ-butenolides
Fulltext Access 7 Pages 2006
Studies on the structure and equilibration of (π-allyl)palladium complexes of phosphino(oxazolinyl)ferrocene ligands
Fulltext Access 7 Pages 2006
Determination of the absolute configuration of chiral cyclic alcohols using diamine derivatizing agents by 31P NMR spectroscopy
Fulltext Access 7 Pages 2006
Enantioseparation of protonated primary arylalkylamines and amino acids containing an aromatic moiety on a pyridino-crown ether based new chiral stationary phase
Fulltext Access 7 Pages 2006
Enantiomer separation by enantioselective inclusion complexation–organic solvent nanofiltration
Fulltext Access 7 Pages 2006
Synthesis of chiral 1-ferrocenylaldols and 1-ferrocenyl-1,3-diols via asymmetric reductions
Fulltext Access 7 Pages 2006
Synthesis of chiral norbornane derivatives as γ-amino alcohol catalysts: the effect of the functional group positions on the chirality transfer
Fulltext Access 7 Pages 2006
Lipase-catalyzed separation of the enantiomers of 1-arylideneamino-3-aryloxypropan-2-ol-N-oxides. Preparation of optically active nitrones
Fulltext Access 7 Pages 2006
Cumulative author index
Fulltext Access 7 Pages 2006
Organoselenium mediated asymmetric cyclizations. Synthesis of enantiomerically pure 1,6-dioxaspiro[4.4]nonanes
Fulltext Access 7 Pages 2006
Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthetic analogues
Fulltext Access 7 Pages 2006
cis-trans Enantiomerism in the Diels-Alder cycloadducts of 6-arylfulvenes with maleic anhydride: resolution of the exo adducts via the N-((1S)-1-(naphth-1-yl)ethyl)imide derivatives: assignment of the absolute configurations based on the crystal structure
Fulltext Access 7 Pages 2006
Enantioselective synthesis of epimeric cis-3-carboxycyclopentylglycines
Fulltext Access 7 Pages 2006
Total synthesis of two naturally occurring polyacetylenic glucosides (−)-bidensyneoside A1 and B, and an analogue of (−)-bidensyneoside C
Fulltext Access 7 Pages 2006
A stereoselective synthetic approach to (2S,3R)-N-(1′,1′-dimethyl-2′,3′-epoxypropyl)-3-hydroxytryptophan, a component of cyclomarin A
Fulltext Access 7 Pages 2006
Graphical contents list
Fulltext Access 7 Pages 2006
A 4D-QSAR study on anti-HIV HEPT analogues
Fulltext Access 7 Pages 2006
Interactions of some modified mono- and bis-β-cyclodextrins with bovine serum albumin
Fulltext Access 7 Pages 2006
Antifungal properties of new series of quinoline derivatives
Fulltext Access 7 Pages 2006
Synthesis and antibacterial activity of N-[2-[5-(methylthio)thiophen-2-yl]-2-oxoethyl] and N-[2-[5-(methylthio)thiophen-2-yl]-2-(oxyimino)ethyl]piperazinylquinolone derivatives
Fulltext Access 7 Pages 2006
Isolation and characterization of a monoamine oxidase B selective inhibitor from tobacco smoke
Fulltext Access 7 Pages 2006
Interaction of chromium(III) complex of chiral binaphthyl tetradentate ligand with DNA
Fulltext Access 7 Pages 2006
Discovery, structure–activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity
Fulltext Access 7 Pages 2006
Preparation and application of chiral spiro nitrogen-containing ligands for cobalt-catalyzed asymmetric Michael addition
Fulltext Access 7 Pages 2006
Anticonvulsant evaluation and mechanism of action of benzylamino enaminones
Fulltext Access 7 Pages 2006
Synthesis and biological evaluation of linear phenylethynylbenzenesulfonamide regioisomers as cyclooxygenase-1/-2 (COX-1/-2) inhibitors
Fulltext Access 7 Pages 2006
Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide
Fulltext Access 7 Pages 2006
Effects on erythroid differentiation of platinum(II) complexes of synthetic bile acid derivatives
Fulltext Access 7 Pages 2006
Synthesis and biological evaluation of 1,3-diphenylprop-2-en-1-ones possessing a methanesulfonamido or an azido pharmacophore as cyclooxygenase-1/-2 inhibitors
Fulltext Access 7 Pages 2006
QSAR modeling of anti-invasive activity of organic compounds using structural descriptors
Fulltext Access 7 Pages 2006
New quinoxaline 1,4-di-N-oxides. Part 1: Hypoxia-selective cytotoxins and anticancer agents derived from quinoxaline 1,4-di-N-oxides
Fulltext Access 7 Pages 2006
Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L.
Fulltext Access 7 Pages 2006
New biscoumarin derivatives-cytotoxicity and enzyme inhibitory activities
Fulltext Access 7 Pages 2006
Synthesis and evaluation of a 3-position diastereomer of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71)
Fulltext Access 7 Pages 2006
Synthesis and immunosuppressive activity of new artemisinin derivatives. Part 2: 2-[12(β or α)-Dihydroartemisinoxymethyl(or 1′-ethyl)]phenoxyl propionic acids and esters
Fulltext Access 7 Pages 2006
An easy route to optically active 1-substituted-1-pyridyl-methylamines by diastereoselective reduction of enantiopure N-tert-butanesulfinyl ketimines
Fulltext Access 7 Pages 2006
Cumulative author index
Fulltext Access 7 Pages 2006
Chiral NMR discrimination of pyrrolidines using (18-crown-6)-2,3,11,12-tetracarboxylic acid
Fulltext Access 7 Pages 2006
Intermolecular one-pot cyclization of formyl-pyrroles of amino acid esters with norephedrine: stereoselective routes to new tricyclic pyrrole–pyrazine–oxazole fused structures
Fulltext Access 7 Pages 2006
Kinetic resolution of primary alcohols having remote stereogenic centers: lipase mediated kinetic resolution of (±)-3-chloro-3-arylpropanols
Fulltext Access 7 Pages 2006
Enantioselective Diels–Alder reaction of o-quinodimethanes by utilizing tartaric acid ester as a chiral auxiliary
Fulltext Access 7 Pages 2006
Synthesis of new chiral calix[4]arene diamide derivatives for liquid phase extraction of α-amino acid methylesters
Fulltext Access 7 Pages 2006
1,3-Heterazolidines-2-heterounsaturated compounds derived from ephedrines
Fulltext Access 7 Pages 2006
Cumulative author index
Fulltext Access 7 Pages 2006
Chemoenzymatic preparation of optically active secondary amines: a new efficient route to enantiomerically pure indolines
Fulltext Access 7 Pages 2006
New [5]ferrocenophane diphosphine ligands for Pd-catalyzed allylic substitution
Fulltext Access 7 Pages 2006
Highly efficient NMR enantiodiscrimination of 1,1,1,3,3-pentafluoro-2-(fluoromethoxy)-3-methoxypropane, a chiral degradation product of sevoflurane, by heptakis(2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin
Fulltext Access 7 Pages 2006
An easy route to atropoisomeric bipyridine N,N′-dioxides and allylation of aldehydes
Fulltext Access 7 Pages 2006
Synthesis, reactivity and conformational stability of an l-phenylalanine derived oxadiazinanone
Fulltext Access 7 Pages 2006
Lipase-catalyzed resolution of anti-6-substituted 1,3-dioxepan-5-ols
Fulltext Access 7 Pages 2006
A chiral phosphepine–olefin rhodium complex as an efficient catalyst for the asymmetric conjugate addition
Fulltext Access 7 Pages 2006
Significant Parameters in the Optimization of MALDI-TOF-MS for Synthetic Polymers††
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Proteomics of Bovine Myelin Sheath: Characterization of a Truncated Form of P0 by MALDI-TOF/TOF Mass Spectrometry
Fulltext Access 7 Pages 2006
Relating Chromatographic Retention and Electrophoretic Mobility to the Ion Distribution Within Electrosprayed Droplets
Fulltext Access 7 Pages 2006
Benzene Loss from Trityl Cations—A Mechanistic Study
Fulltext Access 7 Pages 2006
CN− Secondary Ions Form by Recombination as Demonstrated Using Multi-Isotope Mass Spectrometry of 13C- and 15N-Labeled Polyglycine
Fulltext Access 7 Pages 2006
Direct Screening of a Dynamic Combinatorial Library Using Mass Spectrometry
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Theoretical and Experimental Evaluation of the Low m/z Transmission of an Electrodynamic Ion Funnel
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Determination of Cooling Rates in a Quadrupole Ion Trap
Fulltext Access 7 Pages 2006
Miniature Toroidal Radio Frequency Ion Trap Mass Analyzer
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Highly enantioselective 1,4-addition of arylzinc reagents to 3-arylpropenals catalyzed by a rhodium–binap complex in the presence of chlorotrimethylsilane
Fulltext Access 7 Pages 2006
A multifunctional proline-based organic catalyst for enantioselective aldol reactions
Fulltext Access 7 Pages 2006
Chiral recognition of dipeptides in phosphatidylcholine aggregates
Fulltext Access 7 Pages 2006
Di-2,2,2-trifluoro-1-(9-anthryl)ethyl fumarate, an easy starting point for the enantioselective preparation of trans-cyclohexene-4,5-dicarboxylate derivatives by Diels–Alder reaction
Fulltext Access 7 Pages 2006
The synthesis of chiral β-ketosulfoxides by enantioselective oxidation and their stereocontrolled reduction to β-hydroxysulfoxides
Fulltext Access 7 Pages 2006
Approach to the stereoselective synthesis of melatonin receptor agonist Ramelteon via asymmetric hydrogenation
Fulltext Access 7 Pages 2006
Graphical contents list
Fulltext Access 7 Pages 2006
Highly enantioselective 1,2-additions of various organolithium reagents to aldehydes
Fulltext Access 7 Pages 2006
Enantioselective self-assembly, crystallographic structure and magnetic properties of the two enantiomers of the optically active canted antiferromagnet [Ru(bpy)3][Mn2(ox)3]
Fulltext Access 7 Pages 2006
Hofmeister series of ionic liquids: kosmotropic effect of ionic liquids on the enzymatic hydrolysis of enantiomeric phenylalanine methyl ester
Fulltext Access 7 Pages 2006
Efficient lipase-catalyzed kinetic resolution of 4-arylmethoxy-3-hydroxybutanenitriles: application to an expedient synthesis of a statin intermediate
Fulltext Access 7 Pages 2006
Synthesis of chiral 1,5-disubstituted pyrrolidinones via electrophile-induced cyclization of 2-(3-butenyl)oxazolines derived from (1R,2S)- and (1S,2R)-norephedrine
Fulltext Access 7 Pages 2006
Consecutive catalytic electrophilic fluorination/amination of β-keto esters: toward α-fluoro-α-amino acids?
Fulltext Access 7 Pages 2006
A Parallel Approach to Post Source Decay MALDI-TOF Analysis
Fulltext Access 7 Pages 2006
First enantiospecific Baker–Venkataraman-rearrangements aiming at the total synthesis of chiral anthrapyran antibiotics
Fulltext Access 7 Pages 2006
Practical syntheses of optically active carbagalactose and their potential application to the carbocyclic analogues of KRN7000
Fulltext Access 7 Pages 2006
A novel design of roof-shaped anthracene-fused chiral prolines as organocatalysts for asymmetric Mannich reactions
Fulltext Access 7 Pages 2006
Synthesis of enantiopure 1-azaspiro[4.5]dec-6-en-8-ones from l-proline derivatives
Fulltext Access 7 Pages 2006
An efficient synthesis of new diastereomeric enantiopure 1-aminocyclopentane-1,2,4-tricarboxylic acids
Fulltext Access 7 Pages 2006
Chiral phosphinyl analogues of 2-C-arylmorpholinols: 2-aryl-3,5-diphenyl-[1,4,2]-oxazaphosphinanes
Fulltext Access 7 Pages 2006
Assignment of the absolute configuration of (+)-5,5′,6,6′-tetrahydro-7,7′-spiro[7H-cyclopenta[b]pyridine], a new inherently chiral spiropyridine, by a nonempirical analysis of its circular dichroism spectrum
Fulltext Access 7 Pages 2006
Practical and highly stereoselective approaches to the total synthesis of (−)-codonopsinine
Fulltext Access 7 Pages 2006
The effect of direct steric interaction between substrate substituents and ligand substituents on enantioselectivities in asymmetric addition of diethylzinc to aldehydes catalyzed by sterically congested ferrocenyl aziridino alcohols
Fulltext Access 7 Pages 2006
A new chiral sulfonamide ligand based on tartaric acid: synthesis and application in the enantioselective addition of diethylzinc to aldehydes and ketones
Fulltext Access 7 Pages 2006
An easy synthesis of robust polymer-supported chiral 1,1′-bi-(2-naphthol)s (BINOLs): application to the catalysis of the oxidation of prochiral thioethers to chiral sulfoxides
Fulltext Access 7 Pages 2006
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