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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Fluvoxamine, a selective serotonin reuptake inhibitor, exerts its antiallodynic effects on neuropathic pain in mice via 5-HT2A/2C receptors
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ERβ mediates the estradiol increase of D2 receptors in rat striatum and nucleus accumbens
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The effects of acute and long-term lithium treatments on trkB neurotrophin receptor activation in the mouse hippocampus and anterior cingulate cortex
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CyclinB2 and BIRC5 genes as surrogate biomarkers for neurite outgrowth in SH-SY5Y subclonal cells
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Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D1 receptor agonist
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SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2′methyl-4′-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): A novel, potent and selective 5-HT1B receptor antagonist
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Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models
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Acetyl-l-carnitine protects striatal neurons against in vitro ischemia: The role of endogenous acetylcholine
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Long-lasting neuropathic pain induced by brachial plexus injury in mice: Role triggered by the pro-inflammatory cytokine, tumour necrosis factor α
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Different roles of two nitric oxide activated pathways in spinal long-term potentiation of C-fiber-evoked field potentials
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Effects of ketamine on acute somatic nociception in wild-type and N-methyl-d-aspartate (NMDA) receptor ɛ1 subunit knockout mice
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Investigation of the SSRI augmentation properties of 5-HT2 receptor antagonists using in vivo microdialysis
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Fluvastatin stabilizes the blood–brain barrier in vitro by nitric oxide-dependent dephosphorylation of myosin light chains
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Binge administration of 3,4-methylenedioxymethamphetamine (“ecstasy”) impairs the survival of neural precursors in adult rat dentate gyrus
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Comparison of inhibitory action of candesartan and enalapril on brain ischemia through inhibition of oxidative stress
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Isolation and pharmacological characterisation of hostoxin-1, a postsynaptic neurotoxin from the venom of the Stephen's banded snake (Hoplocephalus stephensi)
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Cycloheximide impairs acquisition but not extinction of cocaine self-administration
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L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for α5-containing GABAA receptors
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Effects of risperidone on locomotor activity and spatial memory in rats with hippocampal damage
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Postulating that our neurological models for musculoskeletal support, movement, and emotional expression come from archetypal forms in early organisms
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The pathogenesis of post kala-azar dermal leishmaniasis from the field to the molecule: Does ultraviolet light (UVB) radiation play a role?
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Humans are evolutionarily adapted to caloric restriction resulting from ecologically dictated dietary deprivation imposed during the Plio–Pleistocene period
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A general theory of evolution based on energy efficiency: its implications for diseases
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Cartilage anlagen adapt in response to static deformation
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Cooler biologically compatible core body temperatures may prolong longevity and combat neurodegenerative disorders
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Effect of “Dang-Qui-Shao-Yao-San” a Chinese medicinal prescription for dysmenorrhea on uterus contractility in vitro
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Antifungal effects of the volatile oils from Allium plants against Trichophyton species and synergism of the oils with ketoconazole
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Ex vivo/in vitro absorption of STW 5 (Iberogast®) and its extract components
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STW 5 (Iberogast®) reduces afferent sensitivity in the rat small intestine
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Screening the antioxidant and antimicrobial properties of the lichens Parmelia saxatilis, Platismatia glauca, Ramalina pollinaria, Ramalina polymorpha and Umbilicaria nylanderiana
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The presence of natural human antibodies reactive against pharmacologically active pectic polysaccharides from herbal medicines
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Simultaneous analysis of artemisinin and flavonoids of several extracts of Artemisia annua L. obtained from a commercial sample and a selected cultivar
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Antiviral property and mechanisms of a sulphated polysaccharide from the brown alga Sargassum patens against Herpes simplex virus type 1
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Immunomodulatory effects of arabinogalactan-proteins from Baptisia and Echinacea
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Aqueous extract of Schizandra chinensis fruit causes endothelium-dependent and -independent relaxation of isolated rat thoracic aorta
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A characteristic pharmacological action of ‘Yang-invigorating’ Chinese tonifying herbs: Enhancement of myocardial ATP-generation capacity
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The inhibition of gastric mucosal lesion, oxidative stress and neutrophil-infiltration in rats by the lichen constituent diffractaic acid
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Sedating effects of Humulus lupulus L. extracts
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RhoA, Rho kinase, JAK2, and STAT3 may be the intracellular determinants of longevity implicated in the progeric influence of obesity: Insulin, IGF-1, and leptin may all conspire to promote stem cell exhaustion
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CYP3A4 and CYP2D6 inhibitory activities of Indonesian medicinal plants
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Traditional Chinese medicines with caspase-inhibitory activity
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Butea monosperma and chemomodulation: Protective role against thioacetamide-mediated hepatic alterations in Wistar rats
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Estrogenic properties of isoflavones derived from Millettia griffoniana
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Diazepam inhibits the induction and maintenance of LTP of C-fiber evoked field potentials in spinal dorsal horn of rats
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Regulation of CART mRNA in the rat nucleus accumbens via D3 dopamine receptors
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Transforming growth factor-α induces sex-specific neurochemical imbalance in the stress- and memory-associated brain structures
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Prenatal nicotine exposure alters the nicotinic receptor subtypes that modulate excitation of parasympathetic cardiac neurons in the nucleus ambiguus from primarily α3β2 and/or α6βX to α3β4
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Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan
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Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway
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Blockade of group II metabotropic glutamate receptors in the nucleus accumbens produces hyperlocomotion in rats previously exposed to amphetamine
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Improvement of the dissolution rate of indomethacin by a cogrinding technique using polyethylene glycols of various molecular weights
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Individualized cancer chemotherapy integrating drug sensitivity tests, pathological profile analysis and computational coordination – An effective strategy to improve clinical treatment
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Tracing the origins of “fetal origins” of adult diseases: Programming by oxidative stress?
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Is sleep’s ‘supreme mystery’ unraveling? An evolutionary analysis of sleep encounters no mystery; nor does life’s earliest sleep, recently discovered in jellyfish
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Recursive causality in evolution: A model for epigenetic mechanisms in cancer development
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Periodontal disease as one possible explanation for the Mexican paradox
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An Investigation into the Interaction between Taste Masking Fatty Acid Microspheres and Alkaline Buffer using Thermal and Spectroscopic Analysis
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Anisotropic Lattice Contraction in Pharmaceuticals: The Influence of Cryo-Crystallography on Calculated Powder Diffraction Patterns
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An Investigation into the In Vivo Performance Variability of pH Responsive Polymers for Ileo-Colonic Drug Delivery Using Gamma Scintigraphy in Humans
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Phase behavior of beta hydroxy-acids with laureth 4
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Structural determination of the stable and meta-stable forms of atomoxetine HCl using single crystal and powder X-ray diffraction methods
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Enhancement of Transdermal Testosterone Delivery By Supersaturation
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Reduced tabletability of roller compacted granules as a result of granule size enlargement
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Incestuous gene in consanguinophilia and incest: Toward a consilience theory of incest taboo
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Ca-alginate beads loaded with meloxicam: effect of alginate chemical composition on the properties of the beads and ulcerogenicity of the drug
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Dextran-poly-ε-caprolactone micro- and nanoparticles: preparation, characterization and tamoxifen solubilization
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Matrix design for bacteriolytic enzyme encapsulation
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Effect of block architecture on the ability of polyalkylene oxides to overcome multidrug resistance of tumor cells
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Block copolymers of Pluronics and poly-(2-dimethylamino+ethyl methacrylate) for delivery of oligonucleotides into tumor cells
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Release characteristics of diclofenac diethylamine from emulgels containing Pluronic F127
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Chitosan nanocapsules: a new carrier for nasal peptide delivery
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Particularités des essais cliniques en cancérologie : place du pharmacien
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Régénération de l′épithélium respiratoire lésé
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Potentialisation des effets du Δ9-tétrahydrocannabinol (THC) par la carence magnésique chez le rat
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Dommages créés aux biomolécules (lipides, protéines, ADN) par le stress oxydant
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The hematological etiology of osteoporosis
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Epilepsy and migraine: The dopamine hypotheses
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Migrainous scintillating scotoma and headache is ocular in origin: A new hypothesis
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Myopia as a latent phenotype of a pleiotropic gene positively selected for facilitating neurocognitive development, and the effects of environmental factors in its expression
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Parental selection: A third selection process in the evolution of human hairlessness and skin color
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The genetic basis of hair whorl, handedness, and other phenotypes
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A paradigm for viewing biologic systems as scale-free networks based on energy efficiency: Implications for present therapies and the future of evolution
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Why is it so difficult to stop psychiatric drug treatment?: It may be nothing to do with the original problem
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N-Acetylaspartate as a reservoir for glutamate
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Where has all the botox gone? (How) will we ever learn… Using monoclonal antibodies to track botulinum toxin
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Protein ubiquitination, degradation and the proteasome in neuro-degenerative disorders: No clear evidence for a significant pathogenetic role of proteasome failure in Alzheimer disease and related disorders
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Evidence that the Transcendental Meditation program prevents or decreases diseases of the nervous system and is specifically beneficial for epilepsy
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Negative costimulatory molecules: The proximal of regulatory T cells?
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Application à la maladie de Fabry
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How is personality disorder linked to dangerousness? A putative role for early-onset alcohol abuse
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Inactivation of prion proteins via covalent grafting with methoxypoly(ethylene glycol)
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Clinical, phenotypic, and genotypic evidence for Streptococcus sinensis as the common ancestor of anginosus and mitis groups of streptococci
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Obesity and ADHD may represent different manifestations of a common environmental oversampling syndrome: a model for revealing mechanistic overlap among cognitive, metabolic, and inflammatory disorders
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Are New World leishmaniases becoming anthroponoses?
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Osteoarthritis: An example of phenoptosis through autonomic dysfunction?
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Factor XII (Hageman factor) is a missing link between stress and hypercoagulability and plays an important role in the pathophysiology of ischemic stroke
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Are prions related to the emergence of early life?
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A hypothesis: Sunspot cycles may detect pandemic influenza A in 1700–2000 A.D.
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Hierarchy of the heart rhythmogenesis levels is a factor in increasing the reliability of cardiac activity
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Hyperoxia potentiated sonothrombolysis as a method of acute ischemic stroke therapy
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