Synthesis and evaluation of new quinazolone derivatives of nalidixic acid as potential antibacterial and antifungal agents Fulltext Access 7 Pages 2006
Synthesis and antimicrobial activity of new (E)-4-[piperidino (4'-methylpiperidino-, morpholino-) N-alkoxy]stilbenes Fulltext Access 7 Pages 2006
Synthesis, structure and anticancer activity of novel 2,4-diamino-1,3,5-triazine derivatives Fulltext Access 7 Pages 2006
Synthesis, antibacterial and antifungal activity of some new thiazolylhydrazone derivatives containing 3-substituted cyclobutane ring Fulltext Access 7 Pages 2006
Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin Fulltext Access 7 Pages 2006
Synthesis and antimicrobial activity of new bromine-rich pyrrole derivatives related to monodeoxypyoluteorin Fulltext Access 7 Pages 2006
Synthesis, ocular effects, and nitric oxide donation of imidazole amidoximes Fulltext Access 7 Pages 2006
Synthesis, DNA binding and cytotoxicity of new pyrazole emodin derivatives Fulltext Access 7 Pages 2006
Synthesis, antibacterial and antitubercular activities of some 7-[4-(5-amino-[1,3,4]thiadiazole-2-sulfonyl)-piperazin-1-yl] fluoroquinolonic derivatives Fulltext Access 7 Pages 2006
Synthesis and anticonvulsant activity of some potential thiazolidinonyl 2-oxo/thiobarbituric acids Fulltext Access 7 Pages 2006
Synthesis and biological evaluation of new vinyl ester pseudotripeptide proteasome inhibitors Fulltext Access 7 Pages 2006
Nuclear magnetic resonance for studying recognition processes between anandamide and cannabinoid receptors Fulltext Access 7 Pages 2006
Synthesis of compounds with antiproliferative activity as analogues of prenylated natural products existing in Brazilian propolis Fulltext Access 7 Pages 2006
QSAR study of 4-phenylpiperidine derivatives as μ opioid agonists by neural network method Fulltext Access 7 Pages 2006
Synthesis and biological activity of 4-thiazolidinones, thiosemicarbazides derived from diflunisal hydrazide Fulltext Access 7 Pages 2006
Synthesis and studies on some new fluorine containing triazolothiadiazines as possible antibacterial, antifungal and anticancer agents Fulltext Access 7 Pages 2006
New perfluoroalkylated amphiphilic methacrylates bearing sulfinyl group as monomers for biomedical applications: water content and oxygen permeability of their copolymers with DEGMA Fulltext Access 7 Pages 2006
Synthesis and biological activity of new 2-amino-8-chloro-5,5-dioxo[1,2,4]triazolo[2,3-b][1,4,2]benzodithiazines Fulltext Access 7 Pages 2006
Pharmacological activity and hydrolysis behavior of novel ibuprofen glucopyranoside conjugates Fulltext Access 7 Pages 2006
Antiproliferative effect of Baylis–Hillman adducts and a new phthalide derivative on human tumor cell lines Fulltext Access 7 Pages 2006
Heterocyclic analogs of benzanilide derivatives as potassium channel activators. IX Fulltext Access 7 Pages 2006
Chemotherapy of leishmaniasis part III: synthesis and bioevaluation of novel aryl substituted terpenyl pyrimidines as antileishmanial agents Fulltext Access 7 Pages 2006
Design, synthesis and in vivo anticonvulsant screening in mice of Novel phenylacetamides Fulltext Access 7 Pages 2006
Radial distribution function descriptors: an alternative for predicting A2 A adenosine receptors agonists Fulltext Access 7 Pages 2006
Cyclooctadiene Ru(II) complexes of thiophene-2-carboxaldehyde-derived thiosemicarbazones: synthesis, characterization and antiamoebic activity Fulltext Access 7 Pages 2006
Synthesis, characterization and biological studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes with bidentate Schiff bases derived by heterocyclic ketone Fulltext Access 7 Pages 2006
Structural–activity relationship study on C-4 carbon atom of the CB1 antagonist SR141716: synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides Fulltext Access 7 Pages 2006
Synthesis and antiprotozoal activity of some 2-(trifluoromethyl)-1H-benzimidazole bioisosteres Fulltext Access 7 Pages 2006
New tyrosinase inhibitors selected by atomic linear indices-based classification models Fulltext Access 7 Pages 2006
The crystal structures of 3-TAPAP in complexes with the urokinase-type plasminogen activator and picrate Fulltext Access 7 Pages 2006
Synthesis and in vitro evaluation of salvinorin A analogues: Effect of configuration at C(2) and substitution at C(18) Fulltext Access 7 Pages 2006
Protective effects of a standard extract of Mangifera indica L. (VIMANG®) against mouse ear edemas and its inhibition of eicosanoid production in J774 murine macrophages Fulltext Access 7 Pages 2006
Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR Fulltext Access 7 Pages 2006
Effect of polysaccharides from Opuntia ficus-indica (L.) cladodes on the healing of dermal wounds in the rat Fulltext Access 7 Pages 2006
Induction of apoptosis by carbazole alkaloids isolated from Murraya koenigii Fulltext Access 7 Pages 2006
A systematic review of randomised clinical trials of Tripterygium wilfordii for rheumatoid arthritis Fulltext Access 7 Pages 2006
PET imaging and optical imaging with d-luciferin [11C]methyl ester and d-luciferin [11C]methyl ether of luciferase gene expression in tumor xenografts of living mice Fulltext Access 7 Pages 2006
Kinetic investigation on aqueous decomposition of 2-chloroethylnitrososulfamide Fulltext Access 7 Pages 2006
Design and evaluation of new antipsoriatic antedrug candidates having 16-en-22-oxa-vitamin D3 structures Fulltext Access 7 Pages 2006
1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of bloo Fulltext Access 7 Pages 2006
The influence of pH on the G-quadruplex binding selectivity of perylene derivatives Fulltext Access 7 Pages 2006
Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: Synthesis and biological evaluation Fulltext Access 7 Pages 2006
The efficacy of St. John's Wort in patients with minor depressive symptoms or dysthymia – a double-blind placebo-controlled study Fulltext Access 7 Pages 2006
Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849 Fulltext Access 7 Pages 2006
SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): Discovery of antagonist SB-568849 Fulltext Access 7 Pages 2006
Antispermatogenic, antiandrogenic activities of Albizia lebbeck (L.) Benth bark extract in male albino rats Fulltext Access 7 Pages 2006
Identification and characterization of amino-piperidinequinolones and quinazolinones as MCHr1 antagonists Fulltext Access 7 Pages 2006
3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods Fulltext Access 7 Pages 2006
The synthesis and aqueous superoxide anion scavenging of water-dispersible lutein esters Fulltext Access 7 Pages 2006
Discovery of trans-3,4′-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation Fulltext Access 7 Pages 2006
Depeptidization efforts on P3–P2′ α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity Fulltext Access 7 Pages 2006
Nuphar alkaloids with immediately apoptosis-inducing activity from Nuphar pumilum and their structural requirements for the activity Fulltext Access 7 Pages 2006
Synthesis, X-ray crystallographic analysis, and antitumor activity of N-(benzothiazole-2-yl)-1-(fluorophenyl)-O,O-dialkyl-α-aminophosphonates Fulltext Access 7 Pages 2006
Orally active thrombin inhibitors. Part 1: Optimization of the P1-moiety Fulltext Access 7 Pages 2006
CA224, a non-planar analogue of fascaplysin, inhibits Cdk4 but not Cdk2 and arrests cells at G0/G1 inhibiting pRB phosphorylation Fulltext Access 7 Pages 2006
Synthesis and antiinflammatory activity of 4-amino-2-aryl-5-cyano-6-{3- and 4-(N-phthalimidophenyl)} pyrimidines 1 Fulltext Access 7 Pages 2006
3D QSAR studies of N-4-arylacryloylpiperazin-1-yl-phenyl-oxazolidinones: A novel class of antibacterial agents Fulltext Access 7 Pages 2006
Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors Fulltext Access 7 Pages 2006
3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: A new class of CDK2 inhibitors Fulltext Access 7 Pages 2006
A density functional study of flavonoid compounds with anti-HIV activity Fulltext Access 8 Pages 2006
Synthesis and biological evaluation of 1β-methylcarbapenems having cyclic thiourea moieties and their related compounds Fulltext Access 8 Pages 2006
Induction of promotive rather than suppressive immune responses from a novel NKT cell repertoire Vα19 NKT cell with α-mannosyl ceramide analogues consisting of the immunosuppressant ISP-I as the sphingosine unit Fulltext Access 8 Pages 2006
Physico-chemical characterization of disoxaril–dimethyl-β-cyclodextrin inclusion complex and in vitro permeation studies Fulltext Access 8 Pages 2006
Synthesis of oxysterols and nitrogenous sterols with antileishmanial and trypanocidal activities Fulltext Access 8 Pages 2006
Synthesis and in vitro microbiological evaluation of imidazo(4,5-b)pyridinylethoxypiperidones Fulltext Access 8 Pages 2006
Isothiazoles. Part XV. A mild and efficient synthesis of new antiproliferative 5-sulfanylsubstituted 3-alkylaminoisothiazole 1,1-dioxides Fulltext Access 8 Pages 2006
Synthesis and biological activity of 6H-isoindolo[2,1-a]indol-6-ones, analogues of batracylin, and related compounds Fulltext Access 8 Pages 2006
Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of indolylpyrazolones and indolylpyridazinedione Fulltext Access 8 Pages 2006
4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties Fulltext Access 8 Pages 2006
Correlation of antibacterial activity of some N-[5-(2-furanyl)-2-methyl-4-oxo-4H-thieno[2,3-d]pyrimidin-3-yl]-carboxamide and 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno[2,3-d]pyrimidin-4-ones with topological indices using Hansch analysis Fulltext Access 8 Pages 2006
QSAR analysis of meclofenamic acid analogues as selective COX-2 inhibitors Fulltext Access 8 Pages 2006
Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1 Fulltext Access 8 Pages 2006
Comparative QSAR modeling of CCR5 receptor binding affinity of substituted 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas Fulltext Access 8 Pages 2006
Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives Fulltext Access 8 Pages 2006
QSAR analysis of some 5-amino-2-mercapto-1,3,4-thiadiazole based inhibitors of matrix metalloproteinases and bacterial collagenase Fulltext Access 8 Pages 2006
Identification of potent and highly selective chiral tri-amine and tetra-amine μ opioid receptors ligands: An example of lead optimization using mixture-based libraries Fulltext Access 8 Pages 2006
Syntheses and antimicrobial activities of a series of new bis-quaternary ammonium compounds Fulltext Access 8 Pages 2006
Synthesis and cytotoxic activity of substituted 2-phenyl-3-hydroxy-4(1H)-quinolinones-7-carboxylic acids and their phenacyl esters Fulltext Access 8 Pages 2006
Synthesis and antiproliferative activity of some 5-substituted 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles Fulltext Access 8 Pages 2006
Synthesis of pharmaceutically important condensed heterocyclic 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivatives as antimicrobials Fulltext Access 8 Pages 2006
Action mechanisms and structure-activity relationships of PI3Kγ inhibitors on the enzyme: a molecular modeling study Fulltext Access 8 Pages 2006
Cyclic and branched acyl chain galactoglycerolipids and their effect on anti-tumor-promoting activity Fulltext Access 8 Pages 2006
Syntheses of new substituted triazino tetrahydroisoquinolines and β-carbolines as novel antileishmanial agents1 Fulltext Access 8 Pages 2006
Synthesis of new esters and oximes with 4-aminobicyclo[2.2.2]octane structure and evaluation of their antitrypanosomal and antiplasmodial activities Fulltext Access 8 Pages 2006
Affinity of 1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives to the ion channel binding site of the NMDA receptor complex Fulltext Access 8 Pages 2006
Synthesis of a new series of heterocyclic scaffolds for medicinal purposes Fulltext Access 8 Pages 2006
A combined in silico strategy to describe the variation of some 3D molecular properties of β-cyclodextrin due to the formation of inclusion complexes Fulltext Access 8 Pages 2006
Synthesis and QSAR studies on 5-[2-(2-methylprop1-enyl)-1H benzimidazol-1yl]-4,6-diphenyl-pyrimidin-2-(5H)-thione derivatives as antibacterial agents Fulltext Access 8 Pages 2006
Synthesis, anticonvulsant activity and 5-HT1A, 5-HT2A receptor affinity of new N-[(4-arylpiperazin-1-yl)-alkyl] derivatives of 2-azaspiro[4.4]nonane and [4.5]decane-1,3-dione Fulltext Access 8 Pages 2006
Synthesis, characterisation, activities, cell uptake and DNA binding of a trinuclear complex: [{trans-PtCl(NH3)}2μ-{trans-Pd(NH3)(2-hydroxypyridine)-(H2N(CH2)6NH2)2]Cl4 Fulltext Access 8 Pages 2006
Comparison of QSPR models of octanol/water partition coefficient for vitamins and non vitamins Fulltext Access 8 Pages 2006
Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-4(3H)-ones Fulltext Access 8 Pages 2006
Quantitative structure activity relationship studies of aryl heterocycle-based thrombin inhibitors Fulltext Access 8 Pages 2006
Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties Fulltext Access 8 Pages 2006
Synthesis and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3,5-diphenyl-2-pyrazoline derivatives and their Pd(II) complexes Fulltext Access 8 Pages 2006
Synthesis and leishmanicidal activities of 1-(4-X-phenyl)-N′-[(4-Y-phenyl)methylene]-1H-pyrazole-4-carbohydrazides Fulltext Access 8 Pages 2006